Researchers at Karolinska Institutet and Lund University have identified a new treatment strategy for neuroblastoma, an aggressive form of childhood cancer. By combining two antioxidant enzyme inhibitors, they have converted cancer cells in mice into healthy nerve cells. The study is published in the journal Proceedings of the National Academy of Sciences (PNAS).
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A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.
A new study reveals that most people believe they would defy immoral orders from authority figures more than others would.
A research team has successfully visualized the ultrafast dynamics of quasi-particles known as excitons, which are generated in carbon nanotubes (CNTs) upon light excitation.
For Martin Schrimpf, the promise of artificial intelligence is not in the tasks it can accomplish. It’s in what AI might reveal about human intelligence.
He is working to build a “digital twin” of the brain using artificial neural networks — AI models loosely inspired by how neurons communicate with one another.
That end goal sounds almost ludicrously grand, but his approach is straightforward. First, he and his colleagues test people on tasks related to language or vision. Then they compare the observed behavior or brain activity to results from AI models built to do the same things. Finally, they use the data to fine-tune their models to create increasingly humanlike AI.
An intuitive guide to reasoning in LLM and simple inference time techniques to improve reasoning with code implementations
Scientists from the National University of Singapore (NUS) have developed NAPTUNE (Nucleic Acids and Protein biomarkers Testing via Ultra-sensitive Nucleases Escalation), a point-of-care assay that identifies trace amounts of disease-related genetic material, including nucleic acid and protein markers, in less than 45 minutes. Importantly, it accomplished this without the need for laboratory equipment or complex procedures.
Lying at the heart of many modern diagnostics, polymerase chain reaction (PCR) and real-time immunoassays provide high accuracy. However, they are hindered by lengthy processing time, the need for specialized thermal cyclers and skilled personnel. These constraints hamper rapid outbreak management, early cancer screening and bedside decision-making, especially in low-resource settings.
NAPTUNE tackles these challenges by replacing bulky amplification steps with a tandem nuclease cascade that converts biological signals directly into readily detectable DNA fragments, streamlining the diagnostic process.