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Senescent skin cells, often referred to as zombie cells because they have outlived their usefulness without ever quite dying, have existed in the human body as a seeming paradox, causing inflammation and promoting diseases while also helping the immune system to heal wounds.

New findings may explain why: Not all senescent cells are the same.

Researchers from Johns Hopkins University have identified three subtypes of senescent skin cells with distinct shapes, biomarkers, and functions—an advance that could equip scientists with the ability to target and kill the harmful types while leaving the helpful ones intact.

Brain cell-derived extracellular vesicles (EVs) in the blood, carrying diverse cargoes, represent a valuable source of predictive, diagnostic, prognostic, disease-monitoring and treatment-response biomarkers for neurological disorders. This Review summarizes key aspects of EV biology and provides a critical overview of EV biomarker research and therapeutic development in neurology.

Shark fin electrocardiographic (ECG) pattern, also known as ‘Lambda-wave’, ‘giant R waves’, or ‘triangular QRS-ST-T waveform’ is a dangerous ECG pattern associated with ST-elevation myocardial infarction (STEMI). It is formed by the fusion of QRS, ST, and T waves and predicts the high risk of mortality due to cardiogenic shock and ventricular fibrillation. The management should be aggressive with reperfusion via thrombolysis or percutaneous intervention, ideally in the intensive care unit with ventricular assist devices. This ECG pattern may be misdiagnosed as wide complex tachycardia or the ECG changes of hyperkalemia. Thus, differentiating it from other conditions causing similar ECG changes and prompt management is highly important to save the patient from serious complications.

A scientific revolution is underway as researchers push to bring atomic-level precision, once reserved for small molecule drugs, into the realm of nanomedicine. By tightly controlling the structure of nanoscale therapies, they’re creating more effective vaccines and treatments for cancer, infecti

British scientists could experiment with techniques to block sunlight as part of a £50 million government funded scheme to combat global warming. The geo-engineering project is set to be given the go-ahead within weeks and could see scientists explore techniques including launching clouds of reflective particles into the atmosphere or using seawater sprays to make clouds brighter. Another method involves thinning natural cirrus clouds, which act as heat-trapping blankets. If successful, less sunlight will reach the earth’s surface and in turn temporarily cool the surface of earth. It’s thought to be a relatively cheap way to cool the…

“Second Variety” is a science fiction novelette by American writer Philip K. Dick, first published in Space Science Fiction magazine, in May 1953. Set in a world where war between the Soviet Union and United Nations has reduced most of the world to a barren wasteland, the story concerns the discovery, by the few remaining soldiers left, that self-replicating robots originally built to assassinate Soviet agents have gained sentience and are now plotting against both sides. It is one of many stories by Dick to examine the implications of nuclear war, particularly after it has destroyed much or all of the planet. The story was adapted into the movie Screamers in 1995. 00:00 Intro 01:03 Peek into the plot 03:33 Self-Replication and Technological Autonomy 06:51 Current Autonomous Warfare Capabilities 10:30 Space Warfare and the Projection of Terrestrial Conflict 13:14 Current State of Space Warfare 15:22 Wrapping Up =============== 🎬 Loitering munitions system WARMATE • Loitering munitions system WARMATE 📙 🇺🇸 Superintelligence: Paths, Dangers, Strategies https://bookshop.org/a/98861/97801987… The Human Terrain Project — PENTAGON’S attempt to understand The Enemy | ENDEVR Documentary • The Human Terrain Project — PENTAGON’… 📙 🇺🇸 War in the Age of Intelligent Machines https://monoskop.org/images/c/c0/DeLa… =============== Buy the book featured in this video: 📙 🇺🇸 Buy the book Second Variety https://bookshop.org/a/98861/97988883… 🎧 Free Audiobook • Post-Apocalyptic Story “Second Variet… =============== You can find my take on things summarised in the books I wrote. 📙🇺🇸Chronicles of the Machine — Simulated conversations with Philip K. Dick https://buchshop.bod.ch/chronicles-of… 📙🇺🇸Zero Person: Reframing Autistic Cognition Beyond the Self https://buchshop.bod.ch/zero-person-e… 📙🇩🇪Zero Person: Autistische Kognition jenseits des Selbst https://buchshop.bod.ch/zero-person-e… 📙🇺🇸Book order: The end of the I https://www.bod.ch/buchshop/the-end-o… 📙🇩🇪Book order: Das Ende des Ichs https://www.bod.ch/buchshop/das-ende–… 📙🇺🇸 #actuallyautistic — Living with Autism – A Poetic Exploration of the Spectrum https://buchshop.bod.ch/actuallyautis… =============== Image credits: Freepik.

The first genetically engineered synapses have been implanted in a mammal’s brain. Chemical brain signals have been bypassed in the brains of mice and replaced with electrical signals, changing their behaviour in incredible ways. Not only did they become more sociable, they were also less anxious and exhibited fewer OCD-like symptoms. This work has sparked hope that one day we could use this technology to help humans with mental health conditions. But would you want someone making permanent edits to your brain?

For the first time, climate scientists can now link specific fossil fuel companies to climate-related economic damages in particular places. A new method has been developed that can show the exact impact these companies are having on our environment — which the world’s top five emitters linked to trillions of dollars of economic losses. Find out how scientists have managed to piece this together — and whether these companies are about to face massive lawsuits.

As we reflect on the death of Pope Francis, we explore his legacy on scientific issues and his transformative stance on climate change. As the spiritual leader of 1.4 billion Catholics, he became an influential figure in advocating for better care to be taken of our planet. Will his legacy continue with the next Pope?

Chapters:
00:00 Intro.
00:28 First brain engineering in a mammal.
10:57 Landmark in fossil fuel lawsuits.
19:33 Climate legacy of Pope Francis.

Hosted by Rowan Hooper and Penny Sarchet, with guests Alexandra Thompson, James Dinneen, William Schafer, Chris Callahan, Justin Mankin and Miles Pattenden.

Learn more ➤ https://www.newscientist.com/podcasts.

Subscribe ➤ https://bit.ly/NSYTSUBS

03/14/56, episode 42
This episode provided by the Old Time Radio Researchers Group.
www.otrr.org.

I’ve had bad mornings, but not like this. Guy Berkhart wakes up screaming on June 15. He dreams of an explosion and something hitting his head. The same thing happens again the next day, and the next day, and the next. IEEEEEE. Only two people aren’t affected by this “deja vu all over again.” (Quoting Yogi Berra, not the writer of this story, Frederik Pohl.) A combination of Halloween III, Invasion Of The Body Snatchers, and Groundhog Day. You’re led to think one thing, then another, then another twist. (from “The Critical X Minus One” by Jim Fanisher)

Credits (Goldin): Frederick Pohl (author), Fred Collins (announcer), George Lefferts (adaptor), John Larkin (narrator), Daniel Sutter (director), Les Damon, Ginger Jones, Bob Hastings, Connie Lembcke, Stan Early, Kermit Murdock, William Welch (producer)