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High Vitamin B12 May Increase Blood Cancer Risk

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Generative diffusion surrogates with analytical variance schedule

Image generators tune their noise by trial and error, because pictures have no clock. Turbulent plasmas do. By syncing an AI’s noise to the known rate at which particles spread, researchers built a surrogate that matches lab measurements—no tuning required.

The problem: Scientists often need fast, cheaper stand-ins (“surrogates”) for complex computer simulations of physical systems—in this case, systems where particles spread out over time, like heat diffusing or particles scattered by turbulence. A good stand-in should capture not just the average behavior but the full range of possible outcomes, including how spread out and lopsided the distribution becomes.

The tool they used: Generative diffusion models—the same kind of AI behind image generators—work by gradually adding noise to data and learning to reverse that process. But in image generation, there’s no physical meaning to “how much noise at each step”; the schedule is just a tuning choice. In particle transport, though, physicists already know how fast the spread (variance) grows over time, even without knowing the full distribution.

The key idea: The researchers set the noise schedule to match the known rate of spreading. This turns the model’s internal “time” into a real physical clock. The model then learns only the finer details—how the shape of the distribution evolves—without needing actual simulation data at intermediate times.

The result: Tested on particles moving through turbulent plasmas (going from fast, straight-line motion to slow diffusion), the surrogate reproduced the simulated particle distributions, matched the spread measured in the lab, and captured how the distribution’s shape (its “kurtosis,” or tailedness) evolved—all without any hand-tuning. This makes it useful both for fast emulation and for statistical inference from data.

#ArtificialIntelligence #PlasmaPhysics #turbulence #DiffusionModels


Angus Fletcher on Wonderworks: Seek The Untold Story

In February 2022, nine months before ChatGPT launched, a story scientist sat down with me and argued that computers cannot be creative.

Not “aren’t yet.” Cannot.

Angus Fletcher started out as a neuroscientist at the University of Michigan. Then he left the lab to do a PhD in Shakespeare at Yale. Then DARPA, Hollywood, and US Special Operations came knocking. Ask yourself what elite soldiers want from a Shakespeare scholar, because the answer is not what you’d guess.

His case rests on a claim most of the #AI industry has bet billions against: the brain is not a computer, and the difference is physical, not a matter of more data or bigger models. For Angus, story is the operating system of the human brain, and #literature is the engine of science rather than its decorative cousin.

We went for two hours. We argued about my own definition of story, about why a multiplicity might serve us better than a #singularity, and about Humanism versus AI-ism.

Four years and one generative AI gold rush later, I went back and rewatched it. You can decide for yourself whether the past four years proved him wrong or proved his point.

Colonizing the Multiverse: Beyond the Kardashev Scale Into Infinite Universes

Why colonize one universe when reality may offer infinitely many? We explore alternate Earths, multiversal travel, dangerous new worlds, and the rise of Omega-class civilizations spanning entire realities.

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Enjoy Rifftrax: https://nebula.tv/rifftrax?ref=isaaca… 🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall… Visit our Website: http://www.isaacarthur.net ❤️ Support us on Patreon: / isaacarthur ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group: / 1,583,992,725,237,264 📣 Reddit Community: / isaacarthur 🐦 Follow on Twitter / X: / isaac_a_arthur 💬 SFIA Discord Server: / discord Credits: Colonizing the Multiverse: Beyond the Kardashev Scale Into Infinite Universes Written, Produced & Narrated by: Isaac Arthur Editor: Thomas Owens Music Courtesy of Stellardrone & Chris Zabriskie Select imagery/video supplied by Getty Images Chapters 0:00 Intro 2:22 The Geography of Reality 5:30 Why Colonize the Multiverse? 9:30 The First Beachhead 13:52 The Navigation Problem 17:35 Settlement Strategies 28:19 Rifftrax 29:11 Beyond the Kardashev Scale – Omega-Class Civilizations.

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Credits:
Colonizing the Multiverse: Beyond the Kardashev Scale Into Infinite Universes.
Written, Produced \& Narrated by: Isaac Arthur.
Editor: Thomas Owens.
Music Courtesy of Stellardrone \& Chris Zabriskie.
Select imagery/video supplied by Getty Images.

Chapters.
0:00 Intro.
2:22 The Geography of Reality.
5:30 Why Colonize the Multiverse?
9:30 The First Beachhead.
13:52 The Navigation Problem.
17:35 Settlement Strategies.
28:19 Rifftrax.
29:11 Beyond the Kardashev Scale – Omega-Class Civilizations.

Stanford scientists turn a cancer driver into a kill switch

A Stanford-designed molecule turns a major lymphoma-promoting protein against cancer cells, activating their own self-destruct machinery instead of simply blocking tumor growth. In mice, the treatment completely eliminated aggressive human lymphoma tumors within 11 days, although much more testing is needed before it could reach patients.

A foundational model redirects cell fate with just a single stimulus

Which genes need to be controlled to guide a stem cell toward a desired cell type, or to modulate an immune cell’s inflammatory response? A research team has developed a general-purpose computational framework that identifies the key targets needed to steer a cell toward a desired state with a single temporary intervention, without permanently altering its genes.

NUDGE, a foundational technology that redirects cell fate in a desired direction through a minimal, temporary intervention by harnessing the gene regulatory dynamics already present within cells.

Technologies that redirect cell fate have drawn attention as key tools for treating intractable diseases and advancing regenerative medicine, since they can be used to differentiate stem cells into cells with specific functions or to return diseased or aged cells to a near-normal state. Differentiation, for example, refers to the process by which a stem cell becomes a specific cell type with a distinct function, such as a cardiomyocyte or a neuron.

The eye has a hidden cleanup system scientists never knew existed

Scientists have uncovered a previously unknown cleanup system at the back of the eye, revealing a hidden route that allows fluid and waste to escape into the body’s lymphatic system. The discovery challenges long-standing assumptions about how the eye functions and could eventually lead to new approaches for treating serious conditions that cause blindness.

Glaucoma, age-related macular degeneration, and several other major causes of permanent vision loss are associated with the accumulation of fluid, metabolic waste, and inflammatory material in the back of the eye. Until now, researchers have struggled to explain exactly how this sensitive region removes unwanted substances.

A team from the University of British Columbia (UBC) and the University of Toronto has identified a previously unrecognized drainage route called the posterior ocular lymphatic outflow, or POLO pathway. The system appears to carry fluid and waste away from the back of the eye and into the lymphatic network, which helps the body maintain fluid balance, remove waste, and support immune defenses.

Faraday Future unveils a $2,490 humanoid robot for developers and schools

Faraday Future and FF EAI Robotics Ecosystem launched two humanoid robots on 15 October: the $2,490 FF Nova for developers and schools, and the $299 FF Nova Mini for children. Nova’s first 100 units are invitation-only. The launch follows FFR’s agreement to buy FF’s robotics business in a $200M all-stock deal.

Faraday Future and its sister company, FF EAI Robotics Ecosystem (FFR), have launched two humanoid robots: the $2,490 FF Nova and the $299 FF Nova Mini. The companies announced the robots on 15 October in a joint press release.

The companies call Nova the first embodied AI humanoid robot sold in the US for under $2,500. Embodied AI means AI that controls a physical body, such as a robot. TNW has not independently verified the claim.