Mesenchymal stem/stromal cell (MSC)-based therapy holds promise for reversal of bone loss in osteoporosis. This phase 1 study establishes the safety and feasibility of intravenous administration of glycocalyx-engineered human MSCs and provides evidence that MSCs derived from the bone marrow of older individuals with osteoporosis retain clinically meaningful osteoregenerative capacity.
Early-life exposure to both modifiable and nonmodifiable risk factors may induce chronic low-grade inflammation (CLGI), a silent threat potentially driving the rising incidence of early-onset colorectal cancer (EOCRC). Notably, CLGI could promote EOCRC by altering the proinflammatory and immune microenvironment that supports tumor growth and cancer development. In this review, we examine how risk factors disrupt immune homeostasis and contribute to CLGI in young individuals, thereby promoting the development of EOCRC. Additionally, identifying CLGI-specific biomarkers could aid in early detection and diagnosis, while targeting specific molecular pathways may enable personalized therapeutic interventions for EOCRC by reducing the chronic inflammatory threat.
To properly understand aging, we have to understand what is slowly unravelling in individual cells.
What is it that makes our cells become less efficient and more vulnerable to disease over time, and eventually break down?
A new study, led by researchers from the Fritz Lipmann Institute (FLI) in Germany, details new findings about how the energy engine rooms of cells – organelles known as mitochondria – begin to slow down over the years.
About halfway through this interview, my guest stopped answering my questions and started asking me his.
I have recorded 300+ conversations on SingularityFM. Being cross-examined on my own show by the man who literally wrote the book on the Socratic method was not in my notes.
Donald J. Robertson is a cognitive-behavioral psychotherapist, a founding member of Modern Stoicism, and president of the Plato’s Academy Center in Athens. His book, How to Think Like Socrates, makes a claim most of us have forgotten: ancient philosophy was never a body of theory. It was a training regime for the mind.
We recorded this in January 2025. Watching it back now, it reads less like a conversation about #Philosophy and more like a warning about the last eighteen months.
Socrates refused to write anything down. He distrusted a technology that let people carry around answers they had not personally earned.
Twenty-five centuries later, we have machines that will hand us any answer we want, instantly, in fluent and confident prose.
ATM
BRCA1
BRCA2
CA 19–9
CDKN2A
Circulating tumor DNA
Beneath cancer’s genetic chaos, tumor cells may be confined to just a handful of recurring states, revealing a simpler path to treatment.
Cancer is often defined by its complexity: countless mutations, shifting cell populations, and tumors that evolve under pressure. But Andrea Califano’s research points to a surprising possibility: that beneath all that variation, cancer cells may be confined to only a handful of stable states.
It is this hidden order that led Califano, a physicist by training and now a cancer researcher, to describe cancer as a “quantum disease.” The comparison is not literal; rather, it reflects the idea that tumor cells may occupy discrete biological states, much as electrons are limited to specific energy levels in an atom.
