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Flexible batteries kept stable with stretchy metallic films

Stretchable films filled with liquid metal can protect flexible electronic devices from exposure to air and water. The finding could offer a potential way to improve the lifetime of future forms of wearable technology.

Most stretchable materials are highly permeable to gases. This makes it challenging to fully protect flexible electronic devices from things like air and moisture, which can ruin their performance.

Now researchers in China and the US have developed stretchable seals based on liquid metals that block the transport of oxygen and water. The seals are formed of a eutectic gallium indium alloy, which is laminated between two layers of silicone-based polymer.

A novel lactam-based AIE building block for high-performance deep-blue electroluminescent materials

Developing high-performance deep-blue organic light-emitting diodes (OLEDs) requires the emitters to achieve a good balance among emission color, exciton utilization efficiency, and photoluminescence quantum yield (PLQY) in solid films. Herein, we report a new deep-blue emissive building block, abbreviated as PADP.

Immunogenic XAPs are released by NETosis and associated with high-risk vasculopathy in patients with SSc

AutoimmuneDiseases affect nearly 50 million Americans, and 4 out of 5 patients are women.

https://doi.org/10.1172/JCI198291 In this Research Letter, Howard Y. Chang & team show novel autoantibodies target hotspots on the XIST ribonucleoprotein complex in female-biased autoimmune diseases.

1Department of Dermatology and.

2Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.

3RNA Medicine Program, Stanford University, Stanford, California, USA.

4Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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Abstract: In obesity, the heart muscle can thicken, preventing it from relaxing properly between beats

While diet and inflammation likely contribute, the underlying molecular mechanism has been unclear.

https://doi.org/10.1172/JCI196238 Here, Junichi Sadoshima & team find direct stimulation of IL-6 transcription by PPARα in cardiomyocytes plays an important role in mediating the initial development of obesity cardiomyopathy.

The figure indicates binding of PPARα to NFkB (via PLA assay).

1Rutgers New Jersey Medical School Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.

2Precision Medicine Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Address correspondence to: Junichi Sadoshima, Cardiovascular Research Institute, Rutgers Biomedical and Health Science, 185 South Orange Ave., MSB G609, Newark, New Jersey, 7,103, USA. Phone 973.972.8619; Email: [email protected].

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Newly discovered neural connections in fruit flies reveal that inhibitory neurons can also drive movement

Researchers at UC Santa Barbara are coming ever closer to uncovering the neural circuitry that translates stimulus to action, shining light on previously unseen neural connections and lesser-known functions of neurons that underlie behavior. Neuroscientists Durafshan Sakeena Syed, Primoz Ravbar and Julie H. Simpson have found that inhibitory neurons—nerve cells known to be responsible for suppressing movement—actively generate and coordinate the rhythmic limb movements required for grooming in fruit flies.

This work is published in the journal eLife. These findings, according to Syed, do not only demonstrate complexities of the animal nervous system that we are only beginning to learn; they also have potential implications for robotics and biomimetic design.

Mitochondria-Associated MicroRNAs: Emerging Roles in the Pathogenesis of Parkinson’s Disease

💡 by Catanesi, M., et al. (2026). Biomedicines, 14, 313. 📖Read the full text: https://brnw.ch/21x1AQl.

Neurodegenerative diseases continue to challenge modern medicine, with mitochondrial dysfunction emerging as one of their most critical hallmarks. Among the most intriguing recent discoveries is the role of mitochondrial‑localized microRNAs (mito‑miRNAs), small regulatory molecules capable of influencing mitochondrial gene expression and cellular metabolism. As research uncovers their presence and function within the mitochondrial environment, these molecules are gaining attention for their potential involvement in the onset and progression of disorders such as Parkinson’s disease. Understanding how mito‑miRNAs contribute to neuronal vulnerability may open new avenues for diagnostics and therapeutic strategies in neurodegeneration.

Neurodegenerative diseases (NDs) are the most prevalent age-associated disorders, characterized by progressive neuronal loss and cognitive decline. Mitochondrial dysfunction is strictly associated with NDs and represent one of the hallmarks of these disorders, with neurological syndromes frequently representing the primary clinical manifestations of mitochondrial abnormalities. As central regulators of cellular bioenergetics, mitochondria play a pivotal role in both the physiological maintenance and pathogenesis of disease by different regulatory approaches. One of these, microRNAs (miRNAs), a class of small non-coding RNAs, are well-established regulators of gene expression across different biological pathways.

A missing link in how the brain regulates appetite

Bile acids at the center of hepato-ocular crosstalk.

Hepatic dysfunction with ocular pathology has been linked to dysregulated bile acid metabolism.

Bile acid imbalance has been shown to drive ocular injury along the gut-liver-eye axis through direct cytotoxicity, disruption of retinal and lens homeostasis mediated by FXR and TGR5 signaling, and immune activation and these mechanisms are implicated across a spectrum of conditions, ranging from inborn metabolic disorders to acquired cholestatic diseases.

The researchers in this review discuss translational potential of targeting bile acid homeostasis and summarize emerging therapeutic strategies, including bile acid-based interventions, targeted drug delivery, and microbiome modulation, that aim to restore systemic bile acid balance.

Thus, bile acid homeostasis act as a unifying therapeutic framework for hepato-ocular comorbidities. sciencenewshighlights ScienceMission https://sciencemission.com/Hepato-ocular-crosstalk

Health sciences.

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AI + Synthetic Biology: The Most Transformative Technology in Human History | Ben Lamm (Colossal)

This episode was filmed at the 2026 Abundance360 Summit.

This interview explores the groundbreaking work of Colossal in synthetic biology, de-extinction, and AI integration. Colossal CEO Ben Lamm explains how the company is revolutionizing biodiversity preservation, tackling plastic pollution, and creating living products with immense potential.

Get access to metatrends 10+ years before anyone else — https://qr.diamandis.com/metatrends.

Ben Lamm is Co-founder and CEO of Colossal Biosciences

Peter H. Diamandis, MD, is the Founder of XPRIZE, Singularity University, ZeroG, and A360.

Chapters:

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