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The senescent cell epigenome
Posted in life extension
Yang N, Sen P,. The senescent cell epigenome. Aging (Albany NY). 2018; 10:3590â3609. https://doi.org/10.18632/aging.
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Itâs not like moon-walking astronauts donât already have plenty of hazards to deal with. Thereâs less gravity, extreme temperatures, radiationâand the whole place is aggressively dusty. If that werenât enough, it also turns out that the visual-sensory cues we use to perceive depth and distance donât work as expectedâon the moon, human eyeballs can turn into scam artists.
During the Apollo missions, it was a well-documented phenomenon that astronauts routinely underestimated the size of craters, the slopes of hilltops, and the distance to certain objects. Objects appeared much closer than they were, which created headaches for mission control. Astronauts sometimes overexerted themselves and depleted oxygen supplies in trying to reach objects that were further than expected.
This phenomenon has also become a topic of study for researchers trying to explain why human vision functions differently in space, why so many visual errors occurred, and what, if anything, we can do to prepare the next generation of space travelers.
- Once dismissed as a âparty drug,â ketamine is emerging as a potential alternative treatment for depression.
- A growing list of academic medical centers now offer the drug, including Columbia University, which began offering ketamine to patients with severe depression this fall.
- Ketamine works differently from common antidepressants like Celexa or Prozac and has been called âthe most important discovery in half a century.â
- Pharmaceutical companies, including Allergan and Johnson & Johnson, are also working on developing blockbuster antidepressants inspired by ketamine.
Ketamine, a drug once associated with raucous parties, bright lights, and loud music, is increasingly being embraced as an alternative depression treatment for the millions of patients who donât get better after trying traditional medications.
The latest provider of the treatment is Columbia University, one of the nationâs largest academic medical centers.
If classic monster movies and old science experiments are to be believed, life begins with a spark.
Not everybody is convinced by this kind of origin story, so the search continues for sources of energy capable of transforming a prebiotic soup into a life-generating dish. Maybe the secret ingredient isnât anything more shocking than a pinch of salt.
A new study led by researchers from the Earth-Life Science Institute (ELSI) at Tokyo Institute of Technology in Japan has turned their attention to common old sodium chloride as a potential conduit for the chemical energy required for early biochemistry.
The introduction of the gene editing tool CRISPR in 2007 was a revolution in medical science and cell biology. But even though the potential is great, the launch of CRISPR has been followed by debate about ethical issues and the technologyâs degree of accuracy and side effects.
However, in a new study published in Cell, researchers from the Novo Nordisk Foundation Center for Protein Research have described how Cas12a, one of the CRISPR technologies, works at the molecular level. This makes it possible to fine-tune the gene-editing process to achieve specific desired effects.
âIf we compare CRISPR to a car engine, what we have done is make a complete 3D map of the engine and thus gained an understanding of how it works. This knowledge will enable us to fine-tune the CRISPR engine and make it work in various waysâas a Formula 1 racer as well as an off-road truck,â says Professor Guillermo Montoya from the Novo Nordisk Foundation Center for Protein Research.