Lifeboat Foundation: Safeguarding Humanity
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Unlike high tech solutions to climate change like carbon capture systems, Crowther argued, trees are nice because anyone can plant one.

“It’s a beautiful thing because everyone can get involved,” he told The Independent. “Trees literally just make people happier in urban environments, they improve air quality, water quality, food quality, ecosystem service, it’s such an easy, tangible thing.”

READ MORE: Massive restoration of world’s forests would cancel out a decade of CO2 emissions, analysis suggests [The Independent].

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However, when astronomers add up all the mass of normal matter in the universe, a third of it can’t be found. (This missing matter is distinct from the still-mysterious dark matter.) However, the matter might be contained in gigantic strands of hot gas in intergalactic space, which are invisible to optical light telescopes. Data from Chandra X-ray Observatory and other telescopes are on the case: https://go.nasa.gov/2N7nWj6

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The genetic and cellular alterations that define cancer provide the immune system with the means to generate T cell responses that recognize and eradicate cancer cells. However, elimination of cancer by T cells is only one step in the Cancer-Immunity Cycle, which manages the delicate balance between the recognition of nonself and the prevention of autoimmunity. Identification of cancer cell T cell inhibitory signals, including PD-L1, has prompted the development of a new class of cancer immunotherapy that specifically hinders immune effector inhibition, reinvigorating and potentially expanding preexisting anticancer immune responses. The presence of suppressive factors in the tumor microenvironment may explain the limited activity observed with previous immune-based therapies and why these therapies may be more effective in combination with agents that target other steps of the cycle. Emerging clinical data suggest that cancer immunotherapy is likely to become a key part of the clinical management of cancer.

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Genetic, epidemiologic, and biochemical evidence suggests that predisposition to Alzheimer’s disease (AD) may arise from altered cholesterol metabolism, although the molecular pathways that may link cholesterol to AD phenotypes are only partially understood. Here, we perform a phenotypic screen for pTau accumulation in AD-patient iPSC-derived neurons and identify cholesteryl esters (CE), the storage product of excess cholesterol, as upstream regulators of Tau early during AD development. Using isogenic induced pluripotent stem cell (iPSC) lines carrying mutations in the cholesterol-binding domain of APP or APP null alleles, we found that while CE also regulate Aβ secretion, the effects of CE on Tau and Aβ are mediated independent pathways. Efficacy and toxicity screening in iPSC- derived astrocytes and neurons showed that allosteric activation of CYP46A1 lowers CE specifically in neurons and is well tolerated by astrocytes. These data reveal that CE independently regulate Tau and Aβ and identify a druggable CYP46A1-CE-Tau axis in AD.

Van der Kant et al. performed a repurposing drug screen in iPSC-derived AD neurons and identified compounds that reduce aberrant accumulation of phosphorylated Tau (pTau). Reduction of cholesteryl ester levels or allosteric activation of CYP46A1 by lead compounds enhanced pTau degradation independently of APP and Aβ.

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A new chemical process could turn about 90% of the world’s grocery bags, shrink wrap, and other polypropylene waste into clean fuel.

Grocery bags and other trash could be melted down to yield useful products like oil and gas.

The problem: The world’s landfill sites and oceans are being flooded with plastic. A mere 9% of the 8.3 billion tons of plastic produced over the last 65 years has been recycled, according to the United Nations. Over eight million tons of plastic flow into our oceans every year, harming wildlife.

How it works: The technology works on polyolefin waste, the sort of plastic used for grocery bags, toys, and shrink wrap. This sort of plastic accounts for about 23% of plastic waste, according to researchers who describe the process in a paper published in Sustainable Chemistry and Engineering. The new technique uses a process called hydrothermal liquefaction, in which very high temperatures melt pellets of polyolefin and then dissolve them in water. The by-products of this process are oil, gas, or solvents.

Continue reading “A new chemical process could turn a quarter of our plastic waste into clean fuel” | >

The derivation of human embryonic stem cells (hESCs) and the stunning discovery that somatic cells can be reprogrammed into human induced pluripotent stem cells (hiPSCs) holds the promise to revolutionize biomedical research and regenerative medicine. In this Review, we focus on disorders of the central nervous system and explore how advances in human pluripotent stem cells (hPSCs) coincide with evolutions in genome engineering and genomic technologies to provide realistic opportunities to tackle some of the most devastating complex disorders.

Advances in stem cell biology are paving new paths toward their use in the clinic, especially toward understanding and treating neurological and neurodegenerative disease.

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