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Learn how to build or just use Alex Ziskind’s LLM Hardware Calculator.

Understand what hardware you need for the model you want to run locally.

This M4 Max 16 MacBook Pro can handle some of the larger language models.

https://amzn.to/4kyog9V

Apple 2024 MacBook Pro Laptop with M4 Max, 14‑core CPU, 32‑core GPU: Built for Apple Intelligence, 16.2-inch Display, 36GB Unified Memory, 1TB SSD Storage; Silver with AppleCare+ (3 Years)https://m.media-amazon.com/images/I/51MOSiURIHL._AC_SX425_.jpg’:[425,425],’https://m.media-amazon.com/images/I/51MOSiURIHL._AC_SX522_.jpg’:[522,522],’https://m.media-amazon.com/images/I/51MOSiURIHL._AC_SX569_.jpg’:[569,569],’https://m.media-amazon.com/images/I/51MOSiURIHL._AC_SX385_.jpg’:[385,385],’https://m.media-amazon.com/images/I/51MOSiURIHL._AC_SX679_.jpg’:[679,679],’https://m.media-amazon.com/images/I/51MOSiURIHL._AC_SX466_.jpg’:[466,466],’https://m.media-amazon.com/images/I/51MOSiURIHL._AC_SX342_.jpg’:[342,342]}/

Continue reading “Apple M4 Max chip” | >

A Brazilian study published in Nutrients suggests that fish oil may help reduce insulin resistance and improve glucose tolerance by influencing the body’s inflammatory response.

Funded by FAPESP, the study was conducted on rats that, while not obese, exhibited a condition resembling type 2 diabetes—a disorder marked by high blood sugar levels due to diminished insulin effectiveness.

As the authors explain, supplementation with omega-3 fatty acids such as those present in fish oil has been prescribed for individuals with cardiovascular problems and type 2 diabetes, but the effects of these nutrients on insulin resistance without obesity are poorly understood.

Fish oil supplementation modified the profile of defense cells, shifting them from a pro-inflammatory to an anti-inflammatory state, effectively reversing a condition resembling type 2 diabetes.

A Brazilian study published in Nutrients suggests that fish oil may help reduce insulin.

Insulin is a hormone produced by the pancreas, crucial for regulating blood glucose levels. It helps cells in the body absorb glucose from the bloodstream and convert it into energy or store it for future use. Insulin production and action are essential for maintaining stable blood sugar levels. In people with diabetes, the body either does not produce enough insulin (Type 1 diabetes) or cannot effectively use the insulin it does produce (Type 2 diabetes), leading to elevated levels of glucose in the blood. This can cause various health complications over time, including heart disease, kidney damage, and nerve dysfunction. Insulin therapy, where insulin is administered through injections or an insulin pump, is a common treatment for managing diabetes, particularly Type 1. The discovery of insulin in 1921 by Frederick Banting and Charles Best was a landmark in medical science, transforming diabetes from a fatal disease to a manageable condition.

Continue reading “Diabetes Breakthrough: Fish Oil May Reverse Insulin Resistance” | >

We all encounter gels in daily life – from the soft, sticky substances you put in your hair, to the jelly-like components in various foodstuffs. While human skin shares gel-like characteristics, it has unique qualities that are very hard to replicate. It combines high stiffness with flexibility, and it has remarkable self-healing capabilities, often healing completely within 24 hours after injury.

Until now, artificial gels have either managed to replicate this high stiffness or natural skin’s self-healing properties, but not both. Now, a team of researchers from Aalto University and the University of Bayreuth are the first to develop a hydrogel with a unique structure that overcomes earlier limitations, opening the door to applications such as drug delivery, wound healing, soft robotics sensors and artificial skin.

In the breakthrough study, the researchers added exceptionally large and ultra-thin specific clay nanosheets to hydrogels, which are typically soft and squishy. The result is a highly ordered structure with densely entangled polymers between nanosheets, not only improving the mechanical properties of the hydrogel but also allowing the material to self-heal.

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When Bluesky CEO Jay Graber took the SXSW stage this week, she managed to make fun of Mark Zuckerberg without mentioning Meta at all. Her black T-shirt was emblazoned with black text stretching across the chest and sleeves, similar to the style of a T-shirt that the billionaire founder wore at an event last year. Graber’s shirt declared in Latin, Mundus sine Caesaribus. Or, “a world without Caesars.”

On Bluesky, users expressed such excitement over Graber’s T-shirt that the platform decided to sell replicas to raise money for its developer ecosystem.

The $40 shirt, available in sizes S – XL, sold out in roughly 30 minutes.

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Proteins are long molecules that must fold into complex three-dimensional structures to perform their cellular functions. This folding process occasionally goes awry, resulting in misfolded proteins that, if not corrected, can potentially lead to disease. Now, a new study has described a potential mechanism that could help explain why some proteins refold in a different pattern than expected.

The researchers, led by chemists at Penn State, found that a type of misfolding, in which the proteins incorrectly intertwine their segments, can occur and create a barrier to the normal folding process. Correcting this misfold requires high-energy or extensive unfolding, which slows the folding process, leading to the unexpected pattern first observed in the 1990s.

“Misfolded proteins can malfunction and lead to disease,” said Ed O’Brien, professor of chemistry in the Eberly College of Science, a co-hire of the Institute for Computational and Data Sciences at Penn State, and leader of the research team. “So, understanding the mechanisms involved in the folding process can potentially help researchers prevent or develop treatments for diseases caused by misfolding.”

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Using a systems and synthetic biology approach to study the molecular determinants of conversion, Wang et al. find that proliferation history and TF levels drive cell fate in direct conversion to motor neurons.

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Scientists have devised a way to store and read data from individual atoms embedded in tiny crystals only a few millimeters in size (where 1 mm is 0.04 inches). If scaled up, it could one day lead to ultra-high density storage systems capable of holding petabytes of data on a single disc — where 1 PB is equivalent to approximately 5,000 4K movies.

Encoding data as 1s and 0s is as old as the entire history of computing, with the only difference being the medium used to store this data — moving from vacuum tubes flashing on and off, tiny electronic transistors, or even compact discs (CDs), with pits in the surface representing 1s and smoothness indicating 0.

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Battery waste has become an increasing problem in recent years due to the massive demand for consumer electronics like smartphones and laptops, as well as the electrification of the automotive industry.

A recent report from Stanford University in the US, published in the journal Nature Communications, found that recycling lithium-ion batteries is far more environmentally friendly than mining for new materials.

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