Lifeboat Foundation

A KAIST research team developed a microfluidic-based drug screening chip that identifies synergistic interactions between two antibiotics in eight hours. This chip can be a cell-based drug screening platform for exploring critical pharmacological patterns of antibiotic interactions, along with potential applications in screening other cell-type agents and guidance for clinical therapies.

Antibiotic susceptibility testing, which determines types and doses of antibiotics that can effectively inhibit bacterial growth, has become more critical in recent years with the emergence of antibiotic-resistant pathogenic bacteria strains.

To overcome the antibiotic-resistant bacteria, combinatory therapy using two or more kinds of antibiotics has been gaining considerable attention. However, the major problem is that this therapy is not always effective; occasionally, unfavorable antibiotic pairs may worsen results, leading to suppressed antimicrobial effects. Therefore, combinatory testing is a crucial preliminary process to find suitable antibiotic pairs and their concentration range against unknown pathogens, but the conventional testing methods are inconvenient for concentration dilution and sample preparation, and they take more than 24 hours to produce results.

Continue reading “On-chip drug screening for identifying antibiotic interactions in eight hours” »

Researchers at the University of Fribourg’s Adolphe Merkle Institute (AMI) and Hokkaido University in Japan have developed a method to tailor the properties of stress-indicating molecules that can be integrated into polymers and signal damages or excessive mechanical loads with an optical signal.

As part of their research activities within the National Center of Competence in Research Bio-inspired Materials, Professor Christoph Weder, the chair of Polymer Chemistry and Materials at AMI, and his team are investigating polymers that change their color or fluorescence characteristics when placed under mechanical load. The prevailing approach to achieve this function is based on specifically designed sensor molecules that contain weak chemical bonds that break when the applied mechanical force exceeds a certain threshold. This effect can cause a color change or other pre-defined responses. A fundamental limitation of this approach, however, is that the weak bonds can also break upon exposure to light or heat. This lack of specificity reduces the practical usefulness of stress-indicating polymers. It normally also makes the effect irreversible.

Addressing this problem, Weder and Dr. Yoshimitsu Sagara—a Japanese researcher who spent two years in Weder’s group at AMI before joining Hokkaido University as an Assistant Professor—devised a new type of sensor molecule that can only be activated by mechanical force. Unlike in previous force-transducing molecules, no chemical bond breaking takes place. Instead, the new sensor molecules consist of two parts that mechanically interlock. This interconnection prevents the separation of the two parts, while still allowing them to be pushed together or pulled away from each other. Such molecular pushing and pulling causes the molecule’s fluorescence to change from off to on.

Continue reading “Polymer reversibly glows white when stretched” »

Electricity harvested from the sun or wind can be used interchangeably with power from coal or petroleum sources. Or sustainably produced electricity can be turned into something physical and useful. Researchers in Arts & Sciences at Washington University in St. Louis have figured out how to feed electricity to microbes to grow truly green, biodegradable plastic, as reported in the Journal of Industrial Microbiology and Biotechnology.

“As our planet grapples with rampant, petroleum-based plastic use and plastic waste, finding sustainable ways to make bioplastics is becoming more and more important. We have to find new solutions,” said Arpita Bose, assistant professor of biology in Arts & Sciences.

Renewable energy currently accounts for about 11% of total U.S. energy consumption and about 17% of electricity generation.

Continue reading “Creating sustainable bioplastics from electricity-eating microbes” »

How do you observe a process that takes more than one trillion times longer than the age of the universe? The XENON Collaboration research team did it with an instrument built to find the most elusive particle in the universe—dark matter. In a paper to be published tomorrow in the journal Nature, researchers announce that they have observed the radioactive decay of xenon-124, which has a half-life of 1.8 × 10²² years.

“We actually saw this decay happen. It’s the longest, slowest process that has ever been directly observed, and our dark matter detector was sensitive enough to measure it,” said Ethan Brown, an assistant professor of physics at Rensselaer, and co-author of the study. “It’s an amazing to have witnessed this process, and it says that our detector can measure the rarest thing ever recorded.”

The XENON Collaboration runs XENON1T, a 1,300-kilogram vat of super-pure liquid xenon shielded from cosmic rays in a cryostat submerged in water deep 1,500 meters beneath the Gran Sasso mountains of Italy. The researchers search for dark matter (which is five times more abundant than ordinary matter, but seldom interacts with ordinary matter) by recording tiny flashes of light created when particles interact with xenon inside the detector. And while XENON1T was built to capture the interaction between a dark matter particle and the nucleus of a xenon atom, the detector actually picks up signals from any interactions with the xenon.

Continue reading “Dark matter detector observes rarest event ever recorded” »

A new and greatly improved version of an electronic tag, called Marine Skin, used for monitoring marine animals could revolutionize our ability to study sea life and its natural environment, say KAUST researchers.

Marine Skin is a thin, flexible, lightweight polymer-based material with integrated electronics which can track an animal’s movement and diving behavior and the health of the surrounding marine environment. Early versions of the sensors, reported previously, proved their worth when glued onto the swimming crab, Portunus pelagicus.

The latest and much more robust version can operate at unprecedented depths and can also be attached to an animal using a noninvasive bracelet or jacket. This can, when necessary, avoid the need for any glues that might harm an animal’s sensitive skin.

Continue reading “Marine Skin dives deeper for better monitoring” »

The multiplication of integers is a problem that has kept mathematicians busy since Antiquity. The “Babylonian” method we learn at school requires us to multiply each digit of the first number by each digit of the second one. But when both numbers have a billion digits each, that means a billion times a billion or 10¹⁸ operations.

At a rate of a billion operations per second, it would take a computer a little over 30 years to finish the job. In 1971, the mathematicians Schönhage and Strassen discovered a quicker way, cutting calculation time down to about 30 seconds on a modern laptop. In their article, they also predicted that another algorithm—yet to be found—could do an even faster job. Joris van der Hoeven, a CNRS researcher from the École Polytechnique Computer Science Laboratory LIX, and David Harvey from the University of New South Wales (Australia) have found that algorithm.

They present their work in a new article that is available to the scientific community through the online HAL archive. But one problem raised by Schönhage et Strassen remains to be solved: proving that no quicker method exists. This poses a new challenge for theoretical computer science.

Continue reading “A faster method for multiplying very big numbers” »

Researchers at Mount Sinai have developed a novel approach to cancer immunotherapy, injecting immune stimulants directly into a tumor to teach the immune system to destroy it and other tumor cells throughout the body.

The “in situ vaccination” worked so well in patients with advanced-stage lymphoma that it is also undergoing trials in breast and head and neck cancer patients, according to a study published in Nature Medicine in April.

The treatment consists of administering a series of immune stimulants directly into one tumor site. The first stimulant recruits important immune cells called dendritic cells that act like generals of the immune army. The second stimulant activates the dendritic cells, which then instruct T cells, the immune system’s soldiers, to kill cancer cells and spare non-cancer cells. This immune army learns to recognize features of the tumor cells so it can seek them out and destroy them throughout the body, essentially turning the tumor into a cancer vaccine factory.

Researchers are edging closer to a therapy for Angelman syndrome that involves injecting molecules that can edit genes into the fetal brain. They have already succeeded in mice and say the approach could eventually treat people with the syndrome.

The work is of high interest because a similar strategy could also work for other genetic conditions linked to autism.

But the prospect of injecting molecules into fetal brains poses ethical questions, experts caution.

Continue reading “Injecting CRISPR into fetal brain may correct autism mutations” »

A team at George Church’s Harvard lab wants to redesign species with large-scale DNA changes.