Lifeboat Foundation: Safeguarding Humanity
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Aging is the biggest risk factor for cancer, but the mechanisms linking these two processes remain unclear. Using GTEx and TCGA data, we compared genes differentially expressed with age and genes differentially expressed in cancer among nine human tissues. In most tissues, aging and cancer gene expression pattern changed in the opposite direction. The exception was thyroid and uterus, where we found transcriptomic changes in the same direction in aging and in their corresponding cancers. The overlapping sets between genes differentially expressed with age and genes differentially expressed in cancer across tissues were enriched for several processes, mainly cell cycle and the immune system. Moreover, cellular senescence signatures, derived from a meta‐analysis, changed in the same direction as aging in human tissues and in the opposite direction of cancer signatures. Therefore, transcriptomic changes in aging and in cellular senescence might relate to a decrease in cell proliferation, while cancer transcriptomic changes shift toward enhanced cell division. Our results highlight the complex relationship between aging and cancer and suggest that, while in general aging processes might be opposite to cancer, the transcriptomic links between human aging and cancer are tissue‐specific.

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(VATICAN CITY) — Pope Francis on Friday warned tech company executives, diplomats and financiers that the race to create artificial intelligence and other forms of digital development pose the risk of increasing social inequality unless the work is accompanied by an ethical evaluation of the common good.

Francis addressed a Vatican conference that brought government envoys and Facebook and Google representatives together with philosophers, physicists and ethicists. A smattering of academics and Catholic bishops rounded out participants at “The Common Good in the Digital Age” conference.

The three-day gathering is the latest evidence of the Vatican wanting a place in the debate over the prospects and perils of artificial intelligence.

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When the structure of DNA was elucidated in 1953, an unimaginable world of possibilities was opened. But we couldn’t even begin to dream about how we would go about using such powerful knowledge. Thirty years later, PCR — the process to replicate DNA in the lab — was developed, and innovation exploded. In 2001 — nearly twenty years ago — the first full human genome was sequenced and published.

The information we’ve uncovered through DNA is enabling us to explore and develop solutions for a variety of problems, from how to mimic human disease in animal models to finding new treatments and cures for devastating diseases such as cancer and Alzheimer’s.

Our ability to engineer biology is making DNA even more powerful. We are building upon the blueprint that was already there, strengthening it, giving it new and improved functions, and leveraging its characteristics to do useful things for us. Perfect examples include engineering the genomes of T cells to turn them into highly specific cancer fighters or modifying bacteria to produce useful products like insulin, food ingredients, or bioplastics. We are even beginning to use DNA to store information, perhaps one day replacing the physical hard drive.

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Security researcher Axi0mX published the exploit, called “checkm8,” Friday on Github. It affects every Apple device with an A5 through A11 chipset, meaning every iPhone model from 4S to X. Though it isn’t an all-in-one jailbreak on its own, the exploit provides an extensive foundation for researchers to build off of in customizing jailbreaks for every vulnerable model of device that would allow them to totally take over the unit, run software far beyond what Apple normally allows, and program apps to interact and share data in ways that Apple’s protections usually preclude.

Any iPhone device from 2011 to 2017 could soon be jailbroken, thanks to an underlying flaw that there’s no way to patch.

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Great Diet Information: #Longevity

Inflammation is also called the silent killer. It is silent because as your body struggles with inflammation, it also does all it can to maintain balance. This means that symptoms are sometimes hard to decipher and can even be hidden for some time.

Inflammation can be a good thing

A little bit of inflammation is a good thing, a lot can be extremely dangerous. When we are injured or sick, the immune system jump into gear and brings an army of white blood cells to the area of concern by increasing blood flow. For instance, when you get a cut or a scrape it generally becomes puffy, red and hot. This is inflammation – more white blood cells have arrived to handle the situation. Acute inflammation is how the body responds to foreign pathogens – it protects us from harm.

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