Scientists have achieved the first DNA-free CRISPR gene editing in raspberries, reaching 19% efficiency and opening the door to faster breeding of firmer, more resilient berries — though regenerating full plants remains a hurdle.
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Advanced battery electrode processing technologies show promise for cutting energy use in half
Numerous market analyses have shown that over the next five years, demand for lithium-ion batteries for everything from personal electric devices to grid-scale energy storage is expected to grow dramatically.
To meet this demand, battery manufacturing needs to be faster, cheaper, more dependable, less energy-intensive and less wasteful. A key part of lithium-ion battery manufacturing with significant room for improvement is the processing and fabrication of electrodes.
To facilitate advances in this area, researchers at the U.S. Department of Energy’s (DOE) Argonne National Laboratory have conducted a comprehensive review of the scientific literature on advanced electrode processing technologies. The findings are published in the journal Nature Reviews Clean Technology.
X-ray and Radio go ‘Hand in Hand’ in New Image
In 2009, NASA’s Chandra X-ray Observatory released a captivating image: a pulsar and its surrounding nebula that is shaped like a hand. Since then, astronomers have used Chandra and other telescopes to continue to observe this object. Now, new radio data from the Australia Telescope Compact Array (ATCA) has been combined with Chandra’s X-ray data to provide a fresh view of this exploded star and its environment, to help understand its peculiar properties and shape.
At the center of this new image lies the pulsar B1509-58, a rapidly spinning neutron star that is only about 12 miles in diameter. This tiny object is responsible for producing an intricate nebula (called MSH 15–52) that spans over 150 light-years, or about 900 trillion miles. The nebula, which is produced by energetic particles, resembles a human hand with a palm and extended fingers pointing to the upper right in X-rays.
The collapse of a massive star created the pulsar when much of the star crashed inward once it burned through its sustainable nuclear fuel. An ensuing explosion sent the star’s outer layers outward into space as a supernova.
Cambridge study shows stem cell grafts can restore myelin in MS lesions in mice
Multiple sclerosis (MS) is an autoimmune disease where the body’s immune system mistakenly attacks the central nervous system, leading to the destruction of myelin, the protective sheath surrounding nerve fibres. This damage is a leading cause of neurological disability in young adults.
In the early stages of MS, certain cells possess the capacity to partially repair this damage by generating new myelin. However, this regenerative ability reduces significantly in the later, chronic progressive stage of the disease. This decline in repair contributes to further damage to neurons and increasing disability in individuals with progressive MS.
Despite advancements in treatments, current therapies mostly focus on managing symptoms but do not halt or reverse the damage and neurodegeneration caused. This shows the critical need for a more profound understanding of how MS progresses and to explore how stem cell technologies could help MS treatment.
The study, published in the journal Brain, was spearheaded by University of Cambridge scientist Dr. Luca Peruzzotti-Jametti and offers crucial insights into the potential of neural stem cell transplantation in people with progressive MS. While neural stem cell transplants present a promising avenue for repairing the damaged central nervous system, the limits of their capacity to repair are being investigated by researchers.
(Utilizng stem cells for many innovative treatments is not a question of how, but rather when)
A study led by Cambridge researchers has shed light on how neural stem cell grafts could help restore myelin in the central nervous system. The findings suggest that neural stem cell-based therapies hold promise as a potential treatment for chronic demyelinating disorders, particularly progressive multiple sclerosis.
Artificial heart valve found to be safe following long-term test in animals
A research team, led by the Universities of Bristol and Cambridge, demonstrated that the polymer material used to make the artificial heart valve is safe following a six-month test in sheep.
Currently, the 1.5 million patients who need heart valve replacements each year face trade-offs. Mechanical heart valves are durable but require lifelong blood thinners due to a high risk of blood clots, whereas biological valves, made from animal tissue, typically last between eight to 10 years before needing replacement.
The artificial heart valve developed by the researchers is made from SEBS (styrene-block-ethylene/butyleneblock-styrene) – a type of plastic that has excellent durability but does not require blood thinners – and potentially offers the best of both worlds. However, further testing is required before it can be tested in humans.
An artificial heart valve made from a new type of plastic could be a step closer to use in humans, following a successful long-term safety test in animals.
‘Universal’ Cancer Vaccine Destroys Resistant Tumors in Mice
Scientists are making encouraging progress in developing vaccines to treat cancer, but so far the therapies have been restricted to specific types of tumor. Now new research points the way to a universal vaccine that could attack a wider range of cancers.
The research led by a team at the University of Florida focuses on “waking up” the immune system to better respond to more types of cancerous cell – tumors that would otherwise be missed for a variety of reasons.
“What we found is by using a vaccine designed not to target cancer specifically but rather to stimulate a strong immunologic response, we could elicit a very strong anti-cancer reaction,” says neuroscientist Duane Mitchell.
Mental time travel: A new case of autobiographical hypermnesia
Remembering past events in minute detail, revisiting them methodically, and reliving past emotions—this is the peculiarity of people with an exceptional memory of their own lives, known as autobiographical hypermnesia, or hyperthymesia. This fascinating condition remains poorly understood, and each new case contributes to our understanding.
In an article in Neurocase, researchers from Paris Brain Institute and the Memory, Brain, and Cognition Laboratory describe the extraordinary mental life of a 17-year-old girl.
Autobiographical memory refers to our ability to remember experiences that have shaped our lives since childhood. It consists of emotional and sensory memories of places, moments, and people, as well as a set of factual information—such as names and dates—that allows us to orient ourselves when we try to recall an episode from the past.
Microglia gene activity shifts across Alzheimer’s stages, revealing possible therapy targets
Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder that causes progressive memory loss and a decline in mental (i.e., cognitive) abilities. Statistics suggest that between 500,000 and 900,000 people are diagnosed with this disease every year, while several hundreds of thousands experience dementia or other aging-related cognitive decline.
While there are some available treatments designed to delay cognitive decline in individuals with mild or moderate AD symptoms, a cure for the disease has not yet been identified. A better understanding of the neural, genetic, cellular and molecular processes that contribute to the disease’s progression, as well as to neurodegeneration in general, could thus be highly valuable, as it could inform the future development of alternative treatments.
Past neuroscience research has identified the key role of microglia in AD. These are specialized immune cells that monitor the environment in the brain, clearing out damaged cells, debris and pathogens. The dysregulation of these cells has been linked to neurodegeneration and to the progression of AD.