Lifeboat Foundation

Stem cells are pluripotent cells, having a property of differentiating into various types of cells of human body. Several studies have developed mesenchymal stem cells (MSCs) from various human tissues, peripheral blood and body fluids. These cells are then characterized by cellular and molecular markers to understand their specific phenotypes. Dental pulp stem cells (DPSCs) are having a MSCs phenotype and they are differentiated into neuron, cardiomyocytes, chondrocytes, osteoblasts, liver cells and β cells of islet of pancreas. Thus, DPSCs have shown great potentiality to use in regenerative medicine for treatment of various human diseases including dental related problems. These cells can also be developed into induced pluripotent stem cells by incorporation of pluripotency markers and use for regenerative therapies of various diseases. The DPSCs are derived from various dental tissues such as human exfoliated deciduous teeth, apical papilla, periodontal ligament and dental follicle tissue. This review will overview the information about isolation, cellular and molecular characterization and differentiation of DPSCs into various types of human cells and thus these cells have important applications in regenerative therapies for various diseases. This review will be most useful for postgraduate dental students as well as scientists working in the field of oral pathology and oral medicine.

Keywords: Human dental pulp stem cells, Mesenchymal stem cells, Dentin, Pluripotency, Stem cell therapy, Molecular markers.

Core tip: Human dental pulp stem cells (DPSCs) have shown a potentiality for the treatment of various human diseases including dental related problems. The review will overview the information about DPSCs, their isolation, cellular and molecular characterization, differentiation into various types of cells and their applications in regenerative therapies for various diseases. This review will be most useful for postgraduate dental students as well as the scientists working in the field of oral pathology, oral medicine and regenerative medicine.

Continue reading “Human dental pulp stem cells: Applications in future regenerative medicine” »

Tesla and CEO Elon Musk say many Teslas will soon drive themselves, and that up to 1 million private Model 3s will form an autonomous taxi service.

The previous Tesla Roadster Battery range of 1000 km was a conservative estimate. It is the range which users will get if they drive like a maniac. Who can blame them, when the car does 0–100 km/h in under 2 seconds.

Furthermore, Tesla fans also remember that a founders edition with cold gas thrusters is also coming in very limited numbers for hardcore electric car enthusiasts.

It is 2019 and the numbers provided by electric cars have already begun to eclipse the likes of Lamborghini Aventador and Bugatti Veyron. Lamborghini Aventador currently gives 10 MPG (Miles per gallon) or 4.25 km/l in the city, while the Bugatti Veyron delivers an embarrassingly low 7 MPG or 2.97 km/l.

Continue reading “Tesla Roadster Battery Range To Eclipse 1000 Kilometer Mark: Elon Musk” »

The latest version of Toyota’s zero-emissions fuel-cell powered tractor truck was unveiled today in Los Angeles. Developed as part of a joint project with the Kenworth Truck Company, the Port of Los Angeles, and the California Air Resources Board (CARB), the Fuel Cell Electric heavy-duty Truck (FCET) that runs on hydrogen and produces only water as waste is intended to meet or exceed the performance of a conventional diesel truck.

In the first North American stem cell clinical trial for osteoarthritis of the knee patients, 12 patients were given injections of their own stem cells and followed for 12 months. The results show a significant improvement in pain levels and quality of life.

A new report out Wednesday says some popular fruit juices may contain heavy metal contaminants like lead, arsenic, and cadmium. Consumer Reports tested 45 packaged fruit juices and found measurable levels of heavy metal in every product. Long-term exposure to these metals could cause serious health risks, including kidney disease and certain types of cancer. Anna Werner reports.

David Sinclair is a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul Glenn Centre for the Biological Mechanisms of Ageing.

Today we hear from a scientist at the cutting edge of longevity research as Professor Sinclair gives us a fascinating insight into the world of anti-ageing.

Continue reading “PROFESSOR DAVID SINCLAIR | Can Humans Live For 1000 Years? | Modern Wisdom Podcast #066” »

The lionfish is an invasive species that is currently wreaking havoc in the warm waters of the Bahamas, the Caribbean, and the US southwestern Atlantic and Gulf of Mexico coasts. But where did they come from and what makes this normally docile hunter suddenly turn vicious in its new home? To answer these questions, North Carolina State University initiated a study of lionfish genetics to learn more about their origins and how to control them.

Researchers at the XENON dark matter observatory have spotted something incredibly rare. Unfortunately, it’s not dark matter, but it is the next best thing. The detectors at the observatory have spotted the decay of xenon-124, the rarest event ever recorded in human history.

The XENON experiment is designed to detect dark matter, which is not an easy task. The reason that dark matter is so mysterious is that it pretty much never does anything, which makes it hard to spot. Dark matter doesn’t give off light, or have any sort of magnetic field, and it almost never interacts with normal matter in any way.