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We’re continuing to release talks from Ending Age-Related Diseases 2019, our highly successful two-day conference that featured talks from leading researchers and investors, bringing them together to discuss the future of aging and rejuvenation biotechnology.

Dr. Andrei Gudkov of the Roswell Park Comprehensive Cancer Center gave a highly technical and in-depth presentation about the retrobiome, a specific subset of genetics that vary between mammalian species, as a key driver of aging. According to this model, as DNA damage accumulates, senescent cells are less efficiently disposed of by the immune system, strongly contributing to the familiar diseases of aging. He also discussed related topics, including how LINE1 (RTL1), a protein that is produced as part of the retrobiome, may be effective against cancer proliferation.

Continue reading “Andrei Gudkov at Ending Age-Related Diseases 2019” | >

The only in-flight beverages on the 11-seat private jet were bottled water and a genetically modified bacterial slurry designed to prevent the worst effects of hangovers.

A handful of passengers on the short evening flight from Hawthorne to the edge of the Mojave — venture capitalists, a man with a mushroom-based manufacturing company and this reporter — downed the mixture. The pilot, along with two senior SpaceX engineers, politely declined.

At the Apple Valley Airport, a helicopter waited to take us beyond a far ridge, farther from civilization. Miles from paved roads were two tents, a ring of shipping containers and an “H” painted on the dirt marking a makeshift helipad.

Continue reading “As Coachella raged, the L.A. tech world made plans to live on Mars” | >

Together with my fellow member of the World Futures Studies Federation, Dr. Thomas Lombardo, we have begun a YouTube video series of ongoing dialogues on topics pertaining to the future. In this first dialogue we focus on the book Science Fiction: The Evolutionary Mythology of the Future and discuss the nature and value of science fiction in the modern world. We discuss the historical evolution of science fiction and the nature of mythology and why science fiction is the modern mythology. In future dialogues we will delve more deeply into books on science fiction and more broadly on futures studies and future consciousness.

SpaceX now has three of its next-generation Starship rockets under construction, as aerial video shows the latest developments at the company’s facility in Florida.

The first bands of stainless steel for another Starship rocket were put on a stand Thursday, and were captured in a video taken from a flying drone. Former commercial pilot John Winkopp took the video and gave CNBC permission to use his footage.

Starship is a massive rocket that SpaceX is developing to eventually launch cargo and people to the moon and Mars. The rocket is designed to be reusable so SpaceX can launch and land it multiple times, like a commercial airplane.

NOTE FROM TED: Please do not look to this talk for medical advice. We’ve flagged this talk, which was filmed at a TEDx event, because it appears to fall outside TEDx’s content guidelines. Gene therapy remains an emerging field of study. The speaker’s claims only reflect her personal views which are not corroborated by scientific evidence. TEDx events are independently organized by volunteers. The guidelines we give organizers are described in more detail here: http://storage.ted.com/tedx/manuals/tedx_content_guidelines.pdf

Liz Parrish is the CEO of BioViva USA Inc, a company committed to increasing health span and combatting the biggest diseases of our time, the diseases of aging. Liz’s talk introduces us to our species’ age-long battle with disease, our successes and achievements, and our new modern enemies to ultimate health. By using the evidence of what science has achieved and what model organisms can tell us about our journey forward, Liz shows us that with the right mentality we can defeat our foes and obtain the “golden sceptre of health”. With the current advances in gene therapy, we are on the brink of living very different lives with an unlimited amount of genetic choices. Did you know that your age is the risk factor in mortality? Listen to this talk and prepare yourself for the future.

This talk was given at a TEDx event using the TED conference format but independently organized by a local community.

Shortly after publishing a paper demonstrating how its artificial intelligence programs could generate viable lead compounds in just a few weeks, Insilico Medicine has signed a dual-program discovery collaboration with Jiangsu Chia Tai Fenghai Pharmaceutical worth up to $200 million.

Focused on previously undruggable targets in triple-negative breast cancer, the deal includes an upfront payment along with potential milestones and sales-based royalties pegged to any eventual products.

“We are very pleased to establish the partnership with Insilico Medicine, entering the new era of AI-enabled drug development,” Wenyu Xia, general manager of the China-based pharma company, said in a statement. “We look forward to a long-term partnership with Insilico Medicine.”

The research scientists’ warnings come amid rising concern about the power of the big tech companies. Most of the focus has been on the current generation of technology — search, online advertising, social media and e-commerce. But the scientists are worried about a barrier to exploring the technological future, when that requires staggering amounts of computing.

Each big step of progress in computing — from mainframe to personal computer to internet to smartphone — has opened opportunities for more people to invent on the digital frontier.

But there is growing concern that trend is being reversed at tech’s new leading edge, artificial intelligence.

Computer scientists say A.I. research is becoming increasingly expensive, requiring complex calculations done by giant data centers, leaving fewer people with easy access to the computing firepower necessary to develop the technology behind futuristic products like self-driving cars or digital assistants that can see, talk and reason.

Which disease will you die of first? If you survive that one, which disease is next in line? If we are kept alive but unwell and continue to practice medicine the way we do today, we will all get a long list of diseases — we are just going to be stacking up more and more layers of treatment, becoming more and more unhappy and spending more and more time at the doctors.

Many thanks for watching!

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Kind regards.
Adam Ford
- Science, Technology & the Future.

Some researchers continue to insist that simulating neuroscience with computers is the way to go. Others, like me, view these efforts as doomed to failure because we do not believe consciousness is computable. Our basic argument is that brains integrate and compress multiple components of an experience, including sight and smell – which simply can’t be handled in the way today’s computers sense, process and store data.

Brains don’t operate like computers

Living organisms store experiences in their brains by adapting neural connections in an active process between the subject and the environment. By contrast, a computer records data in short-term and long-term memory blocks. That difference means the brain’s information handling must also be different from how computers work.