Lifeboat Foundation: Safeguarding Humanity
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Blog – Page 8548

There’s no sugar coating it—diabetes is shaping up to become one of the greatest health challenges in modern times. According to the World Health Organization (WHO), one in eleven individuals suffers from diabetes, and the condition was the direct cause of 1.6 million deaths in 2016, based on the latest publicly available data. WHO has since designated diabetes as one of four priority noncommunicable diseases (alongside cancer, respiratory and cardiovascular diseases) to be addressed by global health authorities.

Closer to home, more than 400,000 Singaporeans live with the diagnosis of diabetes, says the Ministry of Health. This constitutes ten percent of the local disease burden. Meanwhile, a separate study by the National University of Singapore projected that by 2050, Singapore would be home to one million diabetics if current trends continue. Wary of the insidious consequences of unchecked chronic illness, Singapore’s Health Minister Gan Kim Yong declared a “war on diabetes,” calling for a concerted national effort to prevent disease onset and better manage disease symptoms.

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Last November, CHIPSA Hospital hosted a unique, first-of-its-kind event celebrating the lives of 22 late stage cancer survivors who, according to doctors, shouldn’t even be alive. Surrounded by world-renowned doctors, scientists, and researchers, these patients shared their inspiring stories of how they healed their terminal disease when conventional treatment had failed them.

CHIPSA is not an ordinary hospital. For one, we take patients who are typically told they have no other treatment options left. We then offer those patients innovative immunotherapies that aren’t available anywhere in the United States.

Our collaborative event highlighted the patients who have benefited from those types of therapies, featuring people on all ends of the treatment spectrum: the researchers who developed them, the doctors who administered them, and the patients who received them.

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From insilico meddicine — the beginning of an AI healthcare revolution.

Poly Mamoshina on Machine Learning for small molecule drug discovery and the beginning of an AI healthcare revolution — interviewed at the Undoing Aging conference in Berlin 2019!

Polina Mamoshina is a senior research scientist at Insilico Medicine, Inc (www.insilico.com), a Baltimore-based bioinformatics and deep learning company focused on reinventing drug discovery and biomarker development and a part of the computational biology team of Oxford University Computer Science Department. Polina graduated from the Department of Genetics of the Moscow State University. She was one of the winners of GeneHack a Russian nationwide 48-hour hackathon on bioinformatics at the Moscow Institute of Physics and Technology attended by hundreds of young bioinformaticians. Polina is involved in multiple deep learning projects at the Pharmaceutical Artificial Intelligence division of Insilico Medicine working on the drug discovery engine and developing biochemistry, transcriptome, and cell-free nucleic acid-based biomarkers of aging and disease. She recently co-authored seven academic papers in peer-reviewed journals.

Continue reading “Polina Mamoshina — The Beginning of an AI Healthcare Revolution” | >

The Universe is not what textbook physics tells us except that we perceive it in this way – our instruments and measurement devices are simply extensions of our senses, after all. Reality is not what it seems. Deep down it’s pure information – waves of potentiality – and consciousness creating it all. https://www.ecstadelic.net/top-stories/the-alpha-point-vs-th…sciousness #AlphaPoint vs. #OmegaPoint

“Each of us appears in the divine play in a dual role of creator and actor. A full and realistic enactment of our role in the cosmic drama requires the suspension of our true identity. We have to forget our authorship and follow the script.”

-Stanislav Grof

Our human minds are fractals of the larger cosmic mind and consciousness is all that is. Information, which physicists now claim to be fundamental, requires consciousness to assign meaning to it. In other words, Mind is primary, the Universe is a network of networks of entangled conscious minds, and our experiential reality emerges from confluent digital data streams. So, what’s the basis for such radical claims, you might ask.

Continue reading “The Alpha Point vs. the Omega Point: Ours is one of the possible worlds simulated in absolute consciousness” | >

A new study shows that short-term treatment with the common organ rejection drug rapamycin reverses periodontal bone loss, attenuates inflammation, and makes the oral microbiome revert to a more youthful state in old mice.

What is rapamycin?

Rapamycin (also known as sirolimus) is a macrolide, a class of antibiotics that includes Biaxin (Clarithromycin), Zithromax (Azithromycin), Dificid (Fidoximycin), and Erythromycin. Macrolides inhibit the growth of bacteria and are often used in the treatment of common bacterial infections.

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Nearly one in six deaths from prostate cancer could be prevented if targeted screening was introduced for men at a higher genetic risk of the disease, according to a new UCL-led computer modelling study.

Prostate cancer is the most common form of cancer in men with around 130 new cases diagnosed in the UK every day and more than 10,000 men a year dying as a result of the disease. However, unlike breast and there is currently no national programme for this disease in the UK.

A blood test that detects raised levels of the prostate-specific antigen (PSA) can be used to screen for . However, this test is not a reliable indicator as it does not accurately distinguish between dangerous cancers from harmless ones—leading to both unnecessary operations and missed cancers that are harmful.

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Every year, we’re reminded to return to the pharmacy for a flu shot. Why can’t we have a flu vaccine that offers long-term protection, like those for measles or polio? That’s because the influenza virus continuously evolves, so the immune response we build up one year might not work the next year—or even on the version of the flu you catch the same year. As a result, the virus remains dangerous: last year, it caused more than 60,000 deaths in the United States alone.

New findings, published in Cell, reveal why making a general-purpose vaccine that guards against all versions of the flu is so hard: Instead of improving its memory of the previous version of virus, the develops its response to the new virus variant from scratch, mostly using that have no memory of the virus.

“If we can figure out how to help the immune system to keep building on what it has already learned, we could develop better vaccines for highly evolving viruses like the flu, or HIV, or Hepatitis C,” says Gabriel D. Victora, assistant professor at Rockefeller.

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P53 is the most famous cancer gene, not least because it’s involved in causing over 50% of all cancers. When a cell loses its p53 gene—when the gene becomes mutated—it unleashes many processes that lead to the uncontrolled cell growth and refusal to die, which are hallmarks of cancer growth. But there are some cancers, like kidney cancer, that that had few p53 mutations. In order to understand whether the inactivation of the p53 pathway might contribute to kidney cancer development, Haifang Yang, Ph.D., a researcher with the Sidney Kimmel Cancer Center—Jefferson Health probed kidney cancer’s genes for interactions with p53.

Earlier work found that PBRM1—the second most mutated gene in —could interact with p53. However, other researchers were unable to definitively show that it was truly an important mechanism in kidney cancer.

Rather than looking at the p53 protein itself, first author Weijia Cai a postdoc in Dr. Yang’s lab and other collaborators looked at an activated version of p53, one that is studded with an additional chemical marker—an —at many specific spots.

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