Lifeboat Foundation: Safeguarding Humanity
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Blog – Page 8192

O.,o circa 2014.

Researchers in China are reporting that they’ve taken a big step towards creating a supersonic submarine. This technology, which could just as easily be applied to weaponized torpedoes as military or civilian submarines, could theoretically get from Shanghai to San Francisco — about 6,000 miles — in just 100 minutes. If all this doesn’t sound crazy enough, get this: This new advance by the Chinese is based on supercavitation, which was originally developed by the Soviets in the ’60s, during the Cold War.

As you may already know, it’s a lot harder for an object to move quickly through water than air. This is mostly due to increased drag. Without getting into the complexities of fluid dynamics, water is simply much thicker and more viscous than air — and as a result it requires a lot more energy for an object to push through it. You can experience the increased drag of water yourself next time you’re in a swimming pool: Raise your hand above your head, and then let it fall towards the water. (Or alternatively, if there are people sunbathing nearby, do a belly flop.)

Anyway, much like a small-engined car is ultimately limited by its ability to cut through wind resistance (drag), a submarine or torpedo needs insane amounts of power to achieve high velocity through water. This is why, even in 2014, most submarines and torpedoes can’t go much faster than 40 knots (~46 mph). Higher speeds are possible, but it requires so much power that it’s not really feasible (torpedoes only have so much fuel).

Continue reading “China’s supersonic submarine, which could go from Shanghai to San Francisco in 100 minutes, creeps ever closer to reality” | >

As the COVID-19 cases continue to rise globally, the National Medical Products Administration of China has approved the first-ever antiviral medicine called Favilavir. This medicine is said to possibly treat the now-declared pandemic illness.

Over the weekend, Taizhou’s city government announced that Favilavir, which was initially formulated by a Chinese-owned pharmaceutical firm, is the first medicine authorized to stop the widespread of this fatal illness. At present, this drug is being promoted with the label, Avigan.

According to the Ministry of Science and Technology of China, the Favilavir of Hisun Pharmaceutical is among the three drugs that have presented results for hindering COVID-19 (in initial trials) from spreading and further damaging the health of the people worldwide.

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Now a new manufacturing method dubbed “robotic blacksmithing” has the potential to revolutionize the way high-quality structural parts are made, resulting in a new class of customized and optimized products. I am part of a loose coalition of engineers developing this process, a technique I believe can help revive U.S. manufacturing.

Today’s Technologies

Metal parts are used in all kinds of high-performance and safety-critical applications in transportation, mining, construction and power-generation equipment such as turbine engines. Most are made using one of a small number of classical manufacturing processes that haven’t changed much in decades.

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A new method to accurately record brain activity at scale has been developed by researchers at the Crick, Stanford University and UCL. The technique could lead to new medical devices to help amputees, people with paralysis or people with neurological conditions such as motor neurone disease.

The research in mice, published in Science Advances, developed an accurate and scalable method to record brain activity across large areas, including on the surface and in deeper regions simultaneously.

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The hydra is named after the serpent monster from Greek myth, which regrows two heads each time one is cut off. But freshwater hydras have an even more impressive regenerating ability: an entire hydra can regrow from a small piece of tissue in only a few days.

Biologists are particularly excited by this ability, since many of the networks involved in the healing process developed early in the process of evolution, meaning that they are shared among many animals, including humans.

“In other organisms, like humans, once our brain is injured, we have difficulty recovering because the brain lacks the kind of regenerative abilities we see in hydra,” said researcher Abby Primack.

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The genetic information of an organism is stored within DNA. It contains the code for making other molecules that make all cells and organs of the body functional. Interestingly, only 1% of DNA makes up genes, of which proteins are produced via RNA intermediaries. There is much debate on the role of the remaining DNA, but different types of RNA are thought to be produced from it and direct the fate of the cell. Even though each cell of the body contains the same DNA, how they read and process DNA to make RNA can differ quite dramatically between single cells. This has especially been known for the transcriptome, which includes all RNA that are produced from genes, but not so much for other RNA.

“Genes have been the main focus of biological research for a long time,” says lead author of the study Haruka Ozaki. “We wanted to focus on what we call read coverage of single-cell RNA sequencing (scRNA-seq) data, which also includes RNA that are not products of genes. Although we can measure the amount of different RNA a single cell produces by scRNA-seq technologies, we wanted to come up with a new method that also visualizes specifically read coverage, because only then we can get a full picture of RNA biology and how it contributes to cell biology at the single-cell level.”

To achieve their goal, the researchers developed a new computational tool that they called Millefy uses existing scRNA-seq data to visualize read coverage of single cells as a heat map, illustrating differences between individual cells on a relative scale. The researchers first demonstrated the utility of Millefy in a well-established mouse embryonic stem cell model by showing heterogeneity of read coverage between developing cells. They then applied Millefy to cancer cells from patients with triple-negative breast cancer, a particularly aggressive type of breast cancer. Not only did Millefy show heterogeneity between cancer cells in general, but it revealed heterogeneity in a specific aspect of RNA biology that had previously been unknown.

“Our approach simplifies the investigation of cellular heterogeneity in RNA biology using scRNA-seq data,” says Ozaki. ” Our findings could help identify what makes single cells individual, which would help us understand why patients with the same disease are often treated with varying success. Additionally, to enable rapid progress in field, we made Millefy publicly available to the scientific community.”

Continue reading “Seeing is believing: Visualizing differences in RNA biology between single cells” | >