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Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions

Now online! Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts between individual motifs within cis-regulatory elements and reveal a unified model of biophysically mediated enhancer-promoter communication.

HCN channels in rod bipolar cells of rat retina: subcellular localization, kinetic properties and functional dynamics

  • Liu, J. H., Singh, J. B., Veruki, M. L., & Hartveit, E. (2021). Morphological properties of the axon initial segment-like process of AII amacrine cells in the rat retina. Journal of Comparative Neurology, 529 (16), 3,593 – 3,620.

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  • Promising drug can inhibit aggressive breast cancer

    New research reveals a drug developed by scientists at Oregon Health & Science University may develop into a new treatment for an especially aggressive form of breast cancer.

    A developed by researchers at Oregon Health & Science University offers a promising avenue to treat intractable cases of —a form of cancer that is notoriously aggressive and lacks effective treatments.

    In a study published today in the journal Cell Reports Medicine, researchers describe the effect of a molecule known as SU212 to inhibit an enzyme that is critical to cancer progression. The research was conducted in a humanized mouse model.

    New holography-inspired reconfigurable surface developed for wireless communication

    Reconfigurable intelligent surfaces (RIS) are engineered structures comprised of several elements known as ‘meta-atoms,’ which can reshape and control electromagnetic waves in real-time. These surfaces could contribute to the further advancement of wireless communications and localization systems, as they could be used to reliably redirect, strengthen and suppress signals.

    In conventional applications of RIS for , each meta-atom is controlled by a system known as the ‘,’ which is connected to the surface via electrical cables. While surfaces following this design can attain good results, their reliance on wires and a base station could prevent or limit their real-world deployment.

    Researchers at Tsinghua University and Southeast University recently developed a new RIS that controls itself and does not need to be connected to a base station. This new surface, introduced in a paper published in Nature Electronics, draws inspiration from holography, a well-known method to record and reconstruct an object’s light pattern to produce a 3D image of it.

    Long-term stability for perovskite solar cells achieved with fluorinated barrier compound

    Perovskite solar cells are inexpensive to produce and generate a high amount of electric power per surface area. However, they are not yet stable enough, losing efficiency more rapidly than the silicon market standard. Now, an international team led by Prof. Dr. Antonio Abate has dramatically increased their stability by applying a novel coating to the interface between the surface of the perovskite and the top contact layer. This has even boosted efficiency to almost 27%, which represents the state-of-the-art.

    After 1,200 hours of continuous operation under standard illumination, no decrease in efficiency was observed. The study involved research teams from China, Italy, Switzerland and Germany and has been published in Nature Photonics.

    “We used a fluorinated compound that can slide between the perovskite and the buckyball (C60) contact layer, forming an almost compact monomolecular film,” explains Abate. These Teflon-like molecular layer chemically isolate the perovskite layer from the contact layer, resulting in fewer defects and losses. Additionally, the intermediate layer increases the structural stability of both adjacent layers, particularly the C60 layer, making it more uniform and compact.

    Magnetic materials discovered by AI could reduce rare earth dependence

    Researchers at the University of New Hampshire have harnessed artificial intelligence to accelerate the discovery of new functional magnetic materials, creating a searchable database of 67,573 magnetic materials, including 25 previously unrecognized compounds that remain magnetic even at high temperatures.

    “By accelerating the discovery of sustainable magnetic materials, we can reduce dependence on , lower the cost of electric vehicles and renewable-energy systems, and strengthen the U.S. manufacturing base,” said Suman Itani, lead author and a doctoral student in physics.

    The newly created database, named the Northeast Materials Database, helps to more easily explore all the which play a major role in the technology that powers our world: smartphones, , power generators, electric vehicles and more. But these magnets rely on expensive, imported, and increasingly difficult to obtain rare earth elements, and no new permanent magnet has been discovered from the many magnetic compounds we know exist.

    Mechanoluminescent sensors with dual-function polymer shell offer eco-friendly, high-resolution control

    Mechanoluminescent (ML) materials are attractive for haptic interface sensors for next-generation technologies, including bite-controlled user interface, health care motion monitoring, and piconewton sensing, because they emit light under mechanical stimulation without an external power source. However, their intrinsically broad emission spectra can degrade resolution and introduce noise in sensing applications, necessitating further technological development.

    Addressing this knowledge gap, a team of researchers from the Republic of Korea and the UK, led by Hyosung Choi, a Professor at the Department of Chemistry at Hanyang University, and including Nam Woo Kim, a master’s student at Hanyang University, recently employed a chromatic filtration strategy to pave the way to high-resolution ML haptic sensors. Their findings are published in the journal Advanced Materials.

    In this study, the team coated the conjugated polymer poly(9,9-dioctylfluorene-alt-benzothiadiazole) (F8BT) onto ZnS: Cu to selectively suppress emission below 490 nm, narrowing the full width at half maximum from 94 nm to 55 nm.

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