Lifeboat Foundation

Light is the fastest way to distinguish right- and left-handed chiral molecules, which has important applications in chemistry and biology. However, ordinary light only weakly senses molecular handedness. Researchers from the Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy (MBI), the Israel Institute of Technology (Technion) and Technische Universitaet Berlin (TU Berlin) now report a method to generate and characterize synthetic chiral light, which identifies molecules’ handedness exceptionally distinctly. The results of their joint work have just appeared in Nature Photonics.

Like left and right hands, some molecules in nature have mirror twins. However, while these twin molecules may look similar, some of their properties can be very different. For instance, the handedness—or chirality—of molecules plays an essential role in chemistry, biology, and drug development. While one type of a molecule can cure a disease, its mirror twin—or enantiomer—may be toxic or even lethal.

It is extremely hard to tell opposite chiral molecules apart because they look identical and behave identically unless they interact with another chiral object. Light has long been used to detect chirality—oscillations of the electromagnetic field draw a chiral helix in space along the light propagation direction. Depending on whether the helix twirls clockwise or counterclockwise, the light wave is either right- or left-handed. However, the helix pitch, set by the light wavelength, is about 1000 times bigger than the size of a molecule. So the light helix is a gigantic circle compared to the tiny molecules, which hardly react to its chirality.

RUDN University mathematicians have proven the Hardy-Littlewood-Sobolev (HLS) inequalities for the class of generalized Riesz potentials. These results extend the scope of these potentials in mathematics and physics because the main tools for working with such potentials are based on HLS inequalities. New mathematical tools can greatly simplify calculations in quantum mechanics and other fields of physics. The results of the study are published in the journal Mathematical Notes.

Modern physics describes the world in terms of fields and their potentials—that is, the values of the field at each point. But the physical quantities that we can measure are forces and accelerations, that is, derivatives of the second-order of the potential of the corresponding field. The problem of reconstructing the field configuration with the available values of forces and accelerations observed in experiments is complex and not always analytically solvable. Differentiation operations in multidimensional space—operators are usually used to describe the correlation between the potential of the field and the forces. In particular, electromagnetic and gravitational interactions are described in the language of operators.

Since the potential of the field can be determined up to a constant value, for the convenience of calculations, the initial value of the potential is taken at some point in multidimensional space, or on the border of any spatial area. But in some cases, mathematical models of such fields lead to a singularity, that is, at some points the value of the field becomes infinite, and therefore loses its physical meaning.

The healthcare industry stores some of the sensitive personal information there can be about people: hackers know this and are looking to exploit what they view as an easy target.

Doctors have reported on the first attempts in the United States to use gene editing to help patients fight cancer.

The doctors say one form of gene editing appeared to be safe when tested in three patients. But it is not yet known what long-term effects the method will have on cancer treatment or patient survival rates.

A gene editing tool called CRISPR/Cas9 was used in the tests, which were recently reported in a medical study. The method was discovered in recent years as a way to change the genetic material that make up a person’s DNA.

A combined team of researchers from Lawrence Livermore National Laboratory in the U.S. and Atomic Weapons Establishment in the U.K. has found that rapidly compressing lead to planetary-core type pressures makes it stronger than steel. In their paper published in the journal Physical Review Letters, the group describes how they managed to compress the metal so strongly without melting it.

Defining strength in a material is difficult. Strength can refer to a material’s ability withstand bending or breaking under certain conditions. Making things even more complicated is that the strength of any given material can change under varying conditions—such as when heat or compression are applied. In this new effort, the researchers showed just how difficult it can be to nail down how strong a material is—in this case, lead.

Lead is not very strong. Pressing a fingernail against a car’s battery terminal is enough to create indentations, for example. But the researchers with this new effort report that the metal can be strengthened considerably by exerting extreme pressure.

Bacteriophages (phages) are viruses that specifically destroy bacteria. In the early 20th century, researchers experimented with phages as a potential method for treating bacterial infections. But then antibiotics emerged and phages fell out of favor. With the rise of antibiotic-resistant infections, however, researchers have renewed their interest in phage therapy. In limited cases, patients with life-threatening multidrug-resistant bacterial infections have been successfully treated with experimental phage therapy after all other alternatives were exhausted.

Researchers at University of California San Diego School of Medicine and their collaborators have now for the first time successfully applied phage therapy in mice for a condition that’s not considered a classic bacterial infection: alcoholic liver disease.

The study publishes November 13, 2019 in Nature.

After more than two decades of research, the world finally has an approved Ebola vaccine.

The European Commission granted marketing authorization to Merck’s vaccine, known as Ervebo, on Monday, less than a month after the European Medicines Agency recommended it be licensed. It is currently being used in the Democratic Republic of the Congo under a “compassionate use” or research protocol similar to a clinical trial.

“The European Commission’s marketing authorization of Ervebo is the result of an unprecedented collaboration for which the entire world should be proud,” Ken Frazier, Merck’s chairman and chief executive officer, said in a statement.

U.S distance runner Zach Bitter set a 100-mile run world record in 11 hours, 19 minutes and 13 seconds at the Six Days in the Dome event in Milwaukee on Saturday. He ran 363 laps around the 442-meter track at the Pettit National Ice Center.

He averaged a mile pace of 6:48, which is faster than running a sub-three hour marathon. He ran the first 50 miles in five hours, 40 minutes and 38 seconds before completing the next 50 two minutes faster in five hours, 38 minutes and 35 seconds.

The previous record was 11 hours, 28 minutes and three seconds by Oleg Kharitonov in 2002. The 40-year-old from Manitowoc, Wis. set the American record for 100 miles when he ran a 11:40:55 in 2013.

PureLocker ransomware appears to have links to some of the most prolific cyber-criminal operations active in the world today.