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Genentech is working with the FDA to launch a Phase III study comparing tocilizumab (Actemra) vs. standard of care in hospitalized adult patients with severe COVID-19 pneumonia. The trial hopes to open in April 2020 and test 330 patients. The trial endpoints include clinical status, mortality, mechanical ventilation and ICU variables.

Tocilizumab is the first humanized interleukin-6 (IL-6) drug originally approved for rheumatoid arthritis and is now being tested in COVID-19 patients to reduce lung inflammation. The IV version is also approved for patients who have CAR T cell induced cytokine release syndrome (which includes many multiple myeloma patients.). High IL-6 levels can cause damaging inflammation and tocilizumab blocks the effects of IL-6.

According to Randy Cron, MD, PhD, an expert in cytokine release syndrome, some of the severely ill coronavirus patients have lab features of CRS, also sometimes called cytokine storm syndrome (CSS).

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Professor Ronny Thomale holds a chair for theoretical condensed matter physics, the TP1, at the Julius-Maximilian University of Würzburg. The discovery and theoretical description of new quantum states of matter is a prime objective of his research. “Developing a theory for a new physical phenomenon which then inspires new experiments seeking after this effect is one of the biggest moments in a theoretical physicist’s practice,” he says. In an ideal case, such an effect would even unlock unexpected technological potential.

All this has come together with a recent project which Thomale pursued together with the optical experimental group of Professor Alexander Szameit at the University of Rostock, the results of which have now been published in Science.

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Newborns and babies have so far seemed to be largely unaffected by the coronavirus, but three new studies suggest that the virus may reach the fetus in utero.

Even in these studies, the newborns seemed only mildly affected, if at all — which is reassuring, experts said. And the studies are small and inconclusive on whether the virus does truly breach the placenta.

“I don’t look at this and think coronaviruses must cross across the placenta,” said Dr. Carolyn Coyne of the University of Pittsburgh, who studies the placenta as a barrier to viruses. She was not involved in the new work.

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For the first time, scientists have reprogrammed cells from a 114-year-old woman into induced pluripotent stem cells (iPS cells), a move which they describe as a significant step toward understanding “the underlying mechanisms of extreme longevity and disease resistance.”

iPS cells are adult cells that have been genetically reprogrammed into an embryonic stem cell-like state and are able to give rise to any of the specialized cell types of the body, whether it’s neurons, blood cells, or heart cells.

Until this new project, researchers weren’t even certain whether they could create viable iPS cells from someone so elderly, let alone a supercentenarian. Now they have shown it’s possible to effectively make these aged cells resemble young pluripotent cells, the researchers believe they might have made a step towards the reversal of cellular aging.

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Using transmission electron microscopy (TEM), scientists from the Indian Council of Medical Research (ICMR), managed to image the novel Coronavirus. The image was taken from the throat swab sample of the first laboratory-confirmed novel Coronavirus patient in India.

Scientists tested a total of seven negative-stained virus particles having features of Coronavirus-like particles from the sample.

The novel Coronavirus, which originated in China late last year, has caused a pandemic across the world.

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Moderate consumption of marijuana doesn’t adversely affect lung function, according to a study.

A study published in 2012 in The Journal of the American Medical Association (JAMA) had some good news for people who smoke marijuana: smoking at a rate of one joint a day for as long as seven years doesn’t seem to affect lung function adversely.

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