Lifeboat Foundation: Safeguarding Humanity
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Blog – Page 8007

The last time NASA launched astronauts from the Kennedy Space Center, hundreds of thousands of people showed up to watch the final flight of the space shuttle in July 2011. The expectation, by NASA and others, was that similar crowds would show up when commercial crew flights finally began. The large crowds that showed up for launches like the first Falcon Heavy mission in 2018 or even relatively routine cargo launches appeared to confirm that belief, and NASA was planning for big crowds, not just of the public outside the gates of KSC but also official guests and working media inside, for a historic mission.

Then came the pandemic, and all those plans went out the window.

Now NASA is in the unusual, but understandable, position of telling people not to witness in person one of the agency’s biggest missions in the last decade. “We are asking people to watch from home,” NASA administrator Jim Bridenstine said Friday in a media teleconference about the upcoming SpaceX Demo-2 commercial crew mission.

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To trace the trail of the virus worldwide, Lim’s team is using a new technology called next-generation sequencing at ASU’s Genomics Facility, to rapidly read through all 30,000 chemical letters of the SARS-CoV-2 genetic code, called a genome.

Each sequence is deposited into a worldwide gene bank, run by a nonprofit scientific organization called GISAID. To date, over 16,000 SARS-CoV-2 sequences have been deposited GISAID’s EpiCoVTM Database. The sequence data shows that SARS-CoV-2 originated a single source from Wuhan, China, while many of the first Arizona cases analyzed showed travel from Europe as the most likely source.

Now, using a pool of 382 nasal swab samples obtained from possible COVID-19 cases in Arizona, Lim’s team has identified a SARS-CoV-2 mutation that had never been found before—where 81 of the letters have vanished, permanently deleted from the genome.

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Most newly discharged patients who recently recovered from COVID-19 produce virus-specific antibodies and T cells, suggests a study published on May 3rd in the journal Immunity, but the responses of different patients are not all the same. While the 14 patients examined in the study showed wide-ranging immune responses, results from the 6 of them that were assessed at two weeks after discharge suggest that antibodies were maintained for at least that long. Additional results from the study indicate which parts of the virus are most effective at triggering these immune responses and should therefore be targeted by potential vaccines.

It is not clear why immune responses varied widely across the patients. The authors say this variability may be related to the initial quantities of virus that the patients encountered, their physical states, or their microbiota. Other open questions include whether these immune responses protect against COVID-19 upon re-exposure to SARS-CoV-2, as well as which types of T cells are activated by infection with the virus. It is also important to note that the laboratory tests that are used to detect antibodies to SARS-CoV-2 in humans still need further validation to determine their accuracy and reliability.

“These findings suggest both B and T cells participate in immune-mediated protection against the viral infection,” says co-senior study author Chen Dong of Tsinghua University. “Our work has provided a basis for further analysis of protective immunity and for understanding the mechanism underlying the development of COVID-19, especially in severe cases. It also has implications for designing an effective vaccine to protect against infection.”

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The breakthrough, which identified the location and function of every human gene, offered the promise of medical care tailored specifically to individual patients, based on their personal genetic makeup.

When researchers identified a gene associated with a 44 per cent risk of breast cancer in women, for example, it seemed that protecting them might be as simple as deactivating that gene.

But the promise of such personalized medicine has not fully materialized, say two McMaster researchers, because the full sophistication of the genetic blueprint has a more complex and far-reaching influence on human health than scientists had first realized.

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But one of the biggest technical questions still remains: How much data should be transferred from the ATS to the cockpit of the manned aircraft controlling it, and when does that turn into information overload? That question is one Boeing wants to answer more definitively once ATS makes its first flight later this year and moves into its experimentation phase, Arnott said.

“There’s a lot for us to figure out [on] what’s that right level of information feed and direction. One of the great benefits of working with the Royal Australian Air Force is having the real operators [give feedback],” he said. “We don’t have all the answers yet. We have a lot of understanding through our surrogate simulator and surrogate testing that we’re doing, but we will prove that out.”

Boeing first introduced the Airpower Teaming System at the Australian International Airshow at Avalon in February 2019, when the company unveiled a full-scale model. Since then, the company has moved quickly to fabricate the first of three aircraft, completing the fuselage structure this February. In April, the aircraft stood on its own wheels for the first time and powered on.

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Despite the traditional view that species do not exchange genes by hybridisation, recent studies show that gene flow between closely related species is more common than previously thought. A team of scientists from Uppsala University and Princeton University now reports how gene flow between two species of Darwin’s finches has affected their beak morphology. The study is published today in Nature Ecology and Evolution.

Darwin’s finches on the Galápagos Islands are an example of a rapid adaptive radiation in which 18 species have evolved from a common ancestral species within a period of 1–2 million years. Some of these species have only been separated for a few hundred thousand years or less.

Rosemary and Peter Grant of Princeton University, co-authors of the new study, studied populations of Darwin’s finches on the small island of Daphne Major for 40 consecutive years and observed occasional hybridisation between two distinct species, the common cactus finch and the medium ground finch. The cactus finch is slightly larger than the medium ground finch, has a more pointed beak and is specialised to feed on cactus. The medium ground finch has a blunter beak and is specialised to feed on seeds.

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