npj Computational Materials volume 6, Article number: 73 (2020) Cite this article.
Researchers at Tulane University School of Medicine identified a gene that causes an aggressive form of breast cancer to rapidly grow. More importantly, they have also discovered a way to “turn it off” and inhibit cancer from occurring. The animal study results have been so compelling that the team is now working on FDA approval to begin clinical trials and has published details in the journal Scientific Reports.
The team led by Dr. Reza Izadpanah examined the role two genes, including one whose involvement in cancer was discovered by Tulane researchers, play in causing triple negative breast cancer (TNBC). TNBC is considered to be the most aggressive of breast cancers, with a much poorer prognosis for treatment and survival. Izadpanah’s team specifically identified an inhibitor of the TRAF3IP2 gene, which was proven to suppress the growth and spread (metastasis) of TNBC in mouse models that closely resemble humans.
In parallel studies looking at a duo of genes—TRAF3IP2 and Rab27a, which play roles in the secretion of substances that can cause tumor formation —the research teams studied what happens when they were stopped from functioning. Suppressing the expression of either gene led to a decline in both tumor growth and the spread of cancer to other organs. Izadpanah says that when Rab27a was silenced, the tumor did not grow but was still spreading a small number of cancer cells to other parts of the body. However, when the TRAF3IP2 gene was turned off, they found no spread (known as “metastasis” or “micrometastasis”) of the original tumor cells for a full year following the treatment. Even more beneficial, inhibiting the TRAF3IP2 gene not only stopped future tumor growth but caused existing tumors to shrink to undetectable levels.
#Eternal life might not be attainable in the near future, but genetic engineers and doctors are working on new life extension technology. The research could lead to keeping our bodies young, and scientists are developing ways of downloading our brain’s consciousness onto digital media once the body is at the end of its life cycle.
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In this fifteenth episode, Liz Parrish shares her quest for radical life extension and details her two completed gene therapies. She describes the regenerative medical tourism available today for increased lifespan and costs. She relates her company’s mission to create a human that regenerates faster than they degenerate. She details her upcoming gene therapies, including upgraded IQ.
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The World Health Organization (WHO) has changed its advice on face masks, saying they should be worn in public where social distancing is not possible to help stop the spread of coronavirus.
The global body said new information showed they could provide “a barrier for potentially infectious droplets”.
Some countries already recommend or mandate face coverings in public.
Join INTUITIVE Planetarium Director David as he tours the Earth, the Milky Way, and discusses what else resides far beyond using OpenSpace, an open-source tool available online for everyone!
Chinese scientists also found that patients with blood type A were more likely to develop a severe case of COVID-19, according to the Times.
While the Chinese study does support the new study, questions remain on why blood type affects the severity of the illness. “That is haunting me, quite honestly,” said Franke.
The locus where the blood-type gene is located also contains DNA that acts an on-off switch for a gene producing a protein that triggers strong immune responses.
Singapore has only 1% of its land available for agriculture, so it imports 90% of its food requirements. The government is looking to curb this dependence on outside food sources under a programme titled ‘30 by 30,’ which aims to allow Singapore to grow 30% of its produce by the year 2030. Local vertical farms like Sustenir are at the forefront of bringing about this change. VICE visits the sustainable start-up to understand the future of food.
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Stadium-size asteroid will safely fly
Posted in space
While 2020 continues to be a difficult year, there is a little good news to look forward to tonight (June 5): a near-Earth asteroid will whiz safely by our planet, and astronomers may be able to see the monster rock’s flight through telescopes.
The asteroid, known as 2002 NN4, is approaching Earth – but fortunately, not too closely. The space rock will fly by at the equivalent of 13.25 times the distance between Earth and the moon, which is roughly 3.2 million miles (5.2 million kilometers) from our planet. The asteroid’s closest approach to us will be at 11:20 p.m. EDT (0320 GMT June 6).
Global efforts to develop a coronavirus vaccine continue, even as mass protests against racial injustice and police brutality persist in cities across the United States and around the world, raising concerns that the gatherings could spark new waves of infection.
As the number of confirmed coronavirus cases rose to nearly 6.3 million worldwide, experts reaffirmed their hope that at least one promising vaccine candidate could be identified by the end of the year.