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An innovative study of DNA ’s hidden structures may open up new approaches for the treatment and diagnosis of diseases, including cancer.

Researchers at the Garvan Institute have unveiled the first comprehensive map of over 50,000 i-motifs in the human genome, structures distinct from the classic double helix that may play crucial roles in gene regulation and disease. These findings highlight the potential of i-motifs in developing new therapies, particularly in targeting genes associated with cancers.

Unraveling the Mysteries of DNA i-Motifs.

Large-scale earthquakes and tsunamis have historically affected the western regions of the U.S. and Canada and are likely to do so in the future.

Off the southern coasts of British Columbia, Washington, Oregon, and northern California, a 600-mile-long strip exists where the Pacific Ocean floor gradually subducts eastward beneath North America.

This area, called the Cascadia Subduction Zone, hosts a megathrust fault, a place where tectonic plates move against each other in a highly dangerous way. The plates can periodically lock up and build stress over wide areas―eventually to be released when they finally lurch against each other.

Neuralink’s first patient says he’s given his brain-chip implant a name seven months after it was surgically implanted.

Noland Arbaugh, who is quadriplegic and became the first person to get the computer-controlling implant developed by Elon Musk’s brain-interface company, said Wednesday that he had named the device “Eve” and was working with it to improve himself in different ways.

We have to do this ❤️

Replacing research animals with tools that better mimic human biology could improve medicine.

By Rachel Nuwer

When it came time for Itzy Morales Pantoja to start her Ph.D. in cellular and molecular medicine, she chose a laboratory that used stem cells—not only animals—for its research. Morales Pantoja had just spent two years studying multiple sclerosis in mouse models. As an undergraduate, she’d been responsible for ­giving the animals painful injections to induce the disease and then observing as they lost their ability to move. She did her best to treat the mice gently, but she knew they were ­suffering. “As soon as I got close to them, they’d start peeing—a sign of stress,” she says. “They knew what was coming.”

Researchers from Karolinska Institutet have shown that there is a connection between medication against ADHD and a reduced risk of dying prematurely.


Forskare från Karolinska Institutet har visat att det finns ett samband mellan medicinering mot adhd och minskad risk för att dö i förtid. Risken för dödsfall av onaturliga orsaker, som olyckor och överdoseringar, kan minska med en fjärdedel, enligt den nya studien publicerad i JAMA.

Alvaro Morales is the co-founder and CEO of Orb, a flexible usage-based billing engine for modern software pricing models.

Many SaaS companies want to leverage AI in their products. However, since AI is so new, pricing remains volatile. Costs can drop drastically for an AI model when the next iteration is out, and many companies lower their pricing in response to a competitor launch to gain or retain market share.

In addition to the fluctuating and unpredictable model prices, AI pricing is mostly based on usage. Customer usage is usually difficult to predict, which affects the costs your product will incur if it relies on AI models.