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Rewriting the rules of cell division
Findings in Science demonstrate that successful mitosis may draw on more mechanisms than commonly assumed.
Learn more in this Science Perspective.
Microtubules get help from actin filaments during mitosis.
William Bement Authors Info & Affiliations
Science
Vol 388, Issue 6749
Viral evasion of cGAS-STING pathway: opportunities for intervention
The cyclic GMP-AMP (cGAMP) synthase (cGAS) and stimulator of interferon genes (STING) pathway, a crucial component of host innate immunity, detects aberrant DNA during viral infection. It is well established that cGAS-STING signaling activation during viral infections is often insufficient for complete viral clearance, indicating that numerous viruses have evolved countermeasures against this major pathway. However, the precise mechanisms by which viruses antagonize the cGAS-STING pathway to ensure intracellular survival remain incompletely understood. This review synthesizes recent progress in elucidating how diverse RNA and DNA viruses disrupt various stages of cGAS-STING pathway activation. These mechanistic insights into viral evasion have significant implications for the development of targeted therapeutic interventions.
Emergent Complexity
“milliards” means “billions” btw.
Here is Emergent Garden’s thoughts on emergent complexity. I go through a tour of simple systems that produce unexpected complexity, and try to break down emergence into more general and useful ideas. We talk about snowflakes and ant colonies, cellular automata and universe simulations, and the many weird ideas of Stephen Wolfram. I also offer some advice for creating and encouraging emergent behavior. This video is important to me. Emergence is the most interesting thing in the universe.
~SUPPORT ME~
Scrimba: https://scrimba.com/?via=EmergentGarden.
Patreon: https://www.patreon.com/emergentgarden.
Ko-fi: https://ko-fi.com/emergentgarden.
Twitter: https://twitter.com/max_romana.
Bluesky: https://bsky.app/profile/emergentgarden.bsky.social.
~SOURCES~
Particle Life: https://sandbox-science.com/particle-life.
Universe Sandbox: https://universesandbox.com/
Lego Galaxy: https://www.youtube.com/watch?v=djLyoDmSPF0
Big Bang: https://svs.gsfc.nasa.gov/12656/
Emergence Animation: https://www.pexels.com/video/an-artist-s-illustration-of-art…-25744130/
Ants Solving Maze: https://www.reddit.com/r/Damnthatsinteresting/comments/1hlyv…_maneuver/
Neuron Footage: https://www.youtube.com/watch?v=2TIK9oXc5Wo.
Snowflake Footage: https://www.youtube.com/watch?v=q-PQk2-Po-g.
The Life Engine: https://thelifeengine.net.
Water Molecule Sim: https://twitter.com/EdgarGonzalezGT/status/1877078173910753452
Langton’s Ant Simulator: https://evolvecode.io/turmites/index.html.
Conway’s Game of Life: https://playgameoflife.com/
Recursive Game of Life: https://oimo.io/works/life/
A New Kind of Science: https://www.wolframscience.com/nks/
Stephen Wolfram Podcasts: https://www.youtube.com/watch?v=PdE-waSx-d8&list=PLdwvZsAHiS…9ChTYxtZsD
Complexity, A Guided Tour: https://www.amazon.com/Complexity-Guided-Tour-Melanie-Mitche…atfound-20
Wolfram Hypergraph Simulator: https://met4citizen.github.io/Hypergraph/
Atom Orbital Simulation: https://www.falstad.com/qmatom/
Lego Bonsai Alternate Build: https://www.youtube.com/watch?v=YnuCOrCJojw.
Lego Blocks Made of Legos:
Tornado: https://www.youtube.com/watch?v=LGcGFU_Hi9U
Carl Sagan’s Cosmos: https://archive.org/details/cosmos_1980/COSMOS_01.mp4.
Terry Davis Quote: https://www.youtube.com/watch?v=k0qmkQGqpM8
My Music Guy: https://youtube.com/@acolyte-compositions?si=2P97LlROhNgQYOa
“Deliberate Thought“
Kevin MacLeod (incompetech.com)
Licensed under Creative Commons: By Attribution 3.0
http://creativecommons.org/licenses/by/3.0/
~TIMESTAMPS~
Cell type–specific spatiotemporal control of GFP-tagged protein degradation in mice
New: Alexandra Prado-Mantilla, Terry Lechler et al. develop a mouse line to allow cell type–specific, rapid, and reversible degradation of GFP-tagged proteins.
Prado-Mantilla et al. develop a mouse line to allow cell type–specific, rapid, and reversible degradation of GFP-tagged proteins. Using this line, they dem.
