Lifeboat Foundation

Background The COVID-19 pandemic caused by SARS-CoV-2 coronavirus threatens global public health. Currently, neutralizing antibodies (NAbs) versus this virus are expected to correlate with recovery and protection of this disease. However, the characteristics of these antibodies have not been well studied in association with the clinical manifestations in patients. Methods Plasma collected from 175 COVID-19 recovered patients with mild symptoms were screened using a safe and sensitive pseudotyped-lentiviral-vector-based neutralization assay. Spike-binding antibody in plasma were determined by ELISA using RBD, S1, and S2 proteins of SARS-CoV-2. The levels and the time course of SARS-CoV-2-specific NAbs and the spike-binding antibodies were monitored at the same time.

During World War II, an amazing amount of innovation, including radar, reliable torpedoes, and code-breaking, helped end the war faster. This will be the same with the pandemic. I break the innovation into five categories: treatments, vaccines, testing, contact tracing, and policies for opening up. Without some advances in each of these areas, we cannot return to the business as usual or stop the virus. Below, I go through each area in some detail.

The scientific advances we need to stop COVID-19.

By Bill Gates

Electrical signals measurements such as the ECG (electrocardiogram) can show how the human brain or heart works. Next to electrical signals magnetic signals also reveal something about the activity of these organs. They could be measured with little effort and without skin contact. But the especially weak signals require highly sensitive sensors.

Scientists from the Collaboraive research Center 1261 “Magnetoelectric Sensors” at Kiel University have now developed a new concept for cantilever sensors, with the future aim of measuring these low frequencies of heart and brain activity.

The extremely small, energy-efficient sensors are particularly well-suited for medical applications or mobile microelectronics. This is made possible by the use of electrets. Such material is permanently electrically charged, and is also used in microphones for hearing aids or mobile phones.

The McGill University paleontologist, who died from COVID-19, was known for using multidisciplinary methods to explore the origins of amphibians, birds, and mammals.

Leroy Hood is one of the world’s leading scientists in molecular biotechnology and genomics.

Leroy Hood M.D., Ph.D.

Continue reading “Systems Biology and the Coming of ‘Big’ Science” »

Scientists have discovered which kinds of cells in the human body may be most susceptible to infection by the SARS-CoV-2 virus, identifying putative targets for the pathogen based on the types of proteins produced by cells.

During the original SARS epidemic in the early 2000s, researchers found that the virus responsible, officially designated SARS-CoV, infects cells with the help of two proteins: a receptor called angiotensin-converting enzyme 2 (ACE2), which helps the virus bind to cells, and an enzyme called Type II transmembrane serine protease (TMPRSS2), which mediates the infection of the cell.

Earlier this year, scientists discovered that SARS-CoV-2 — the one that causes COVID-19 — exploits the same two proteins, giving researchers a vital clue to identify the most susceptible targets of the virus at the cellular level: cells in respiratory and intestinal tissue that express both ACE2 and TMPRSS2.

Tesla patents a new NCA electrode that is likely going to be used in its new battery cell built in-house, which is expected to be longer-lasting and cheaper.

We previously reported on Tesla’s battery research partner, Jeff Dahn and his team at Dalhousie University, unveiling the impressive results of tests on a new battery cell that could last over 1 million miles in an electric vehicle.

Continue reading “Tesla patents a new electrode for its 1-million-mile battery” »

The new coronavirus is quickly destroyed by sunlight, according to new research announced by a senior US official on Thursday, though the study has not yet been made public and awaits external evaluation.

William Bryan, science and technology advisor to the Department of Homeland Security secretary, told reporters at the White House that government scientists had found ultraviolet rays had a potent impact on the pathogen, offering hope that its spread may ease over the summer.

“Our most striking observation to date is the powerful effect that solar light appears to have on killing the virus, both surfaces and in the air,” he said.

I’ve been shocked sometimes when I walk in and see the patients. Most of the ones I’ve intubated are young — 30s, 40s, 50s. These are people who walked into the ER because they were coughing a day or two ago, or sometimes hours ago. By the time I come into the room, they are in severe respiratory distress. Their oxygen level might be 70 or 80 percent instead of 100, which is alarming. They are taking 40 breaths a minute when they should be taking 12 or 14. They have no oxygen reserves. They are pale and exhausted. It puts them in a mental fog, and sometimes they don’t hear me when I introduce myself. Some are panicky and gasping. Others are mumbling or incoherent. Last week, one patient was crying and asking to use my phone so they could call family and say goodbye, but their oxygen levels were dropping, and we didn’t have time, and I couldn’t risk bringing my phone in and contaminating it with virus, and the whole thing was impossible. I kept apologizing. I just —. I don’t know. I have to find a way to hold it together in order to do this job. I tear up sometimes, and if I do, it can fog up my face shield.

“It’s a powerless feeling, watching someone die”: An anesthesiologist on the frontline of coronavirus outbreak.