Driverless cars are coming, and they’re likely to make life on the road easier and more convenient — for some of us. But will they create new ethical problems?
Researchers have discovered a new set of signals that cells send and receive to prompt one type of fat cell to convert fat into heat. The signaling pathway, discovered in mice, has potential implications for activating this same type of thermogenic fat in humans.
Thermogenic fat cells, also called beige fat or beige adipocytes, have gained attention in recent years for their potential to curb obesity and other metabolic disorders, due to their ability to burn energy stored as fat. But scientists have yet to translate this potential into effective therapies.
The challenge of activating beige fat in humans arises, in part, because this process is regulated through so-called adrenergic signaling, which uses the hormone catecholamine to instruct beige fat cells to start burning energy. But adrenergic signaling also controls other important biological functions, including blood pressure and heartbeat regulation, so activating it in humans with agonists has potentially dangerous side effects.
Despite pigheaded intransigence at the highest levels of its national government, the renewable energy revolution is coming to Australia in a big way. And why not? Enough sunlight hits what Bill Bryson calls “a sunburned country” every day to meet all of humanity’s energy needs for a year. All it has to do is figure out how to harvest and distribute all that energy. (It could begin by replacing its national leaders with people who possess actual functioning brains, but the same can be said for many nations around the world.)
SpaceX updated the website for its Starlink satellite internet project on Friday, as the company continues to move closer to its goal of offering direct-to-consumer broadband from space later this year.
“Get updates on Starlink news and service availability in your area,” the website reads, with a submission form for an email address and zip code. The form allows prospective customers to apply for updates and access to a public beta test of the Starlink service.
Today, stars fill the night sky. But when the universe was in its infancy, it contained no stars at all. And an international team of scientists is closer than ever to detecting, measuring and studying a signal from this era that has been traveling through the cosmos ever since that starless era ended some 13 billion years ago.
That team—led by researchers at the University of Washington, the University of Melbourne, Curtin University and Brown University—reported last year in the Astrophysical Journal that it had achieved an almost 10-fold improvement of radio emission data collected by the Murchison Widefield Array. Team members are currently scouring the data from this radio telescope in remote Western Australia for a telltale signal from this poorly understood “dark age” of our universe.
Learning about this period will help address major questions about the universe today.
The ability to restore sight to the blind is one of the most profound acts of healing medicine can achieve, in terms of the impact on the affected patient’s life — and one of the most difficult for modern medicine to achieve. We can restore vision in a limited number of scenarios and there are some early bionic eyes on the market that can restore limited vision in very specific scenarios. Researchers may have taken a dramatic step towards changing that in the future, with the results of a new experiment to design a bionic retina.
The research team in question has published a paper in Nature detailing the construction of a hemispherical retina built out of high-density nanowires. The spherical shape of the retina has historically been a major challenge for biomimetic devices.
“And by answering the question, how do psychedelics work, we also inadvertently shine a light on other questions science has shied away from for decades. How do our brains generate our sense of self? What is the neurochemistry of consciousness?”
New research asks, how does psilocybin create a feeling of ego dissolution, and what chemicals in the brain create our subjective sense of self?
The probability of a Carrington-like event is estimated to be 12% per decade – that’s about a 50/50 chance for at least one in the next 50 years. Investments and upgrades, cheap compared to those other natural disasters require, could protect the worlds electric grid against even the nastiest of storms.
Sources here https://sites.google.com/view/sourcessolarflares
Continue reading “Could Solar Storms Destroy Civilization? Solar Flares & Coronal Mass Ejections” »
Good talk, not just about NAD. Q&A just before 35 minutes. A lot of epigenetics here.
David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years. His research has been primarily focused on the sirtuins, protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. The Sinclair lab was the first one to identify a role for NAD+ biosynthesis in regulation of lifespan and first showed that sirtuins are involved in CR in mammals. They first identified small molecules that activate SIRT1 such as resveratrol and studied how they improve metabolic function using a combination of genetic, enzymological, biophysical and pharmacological approaches. They recently showed that natural and synthetic activators require SIRT1 to mediate the in vivo effects in muscle and identified a structured activation domain. They demonstrated that miscommunication between the mitochondrial and nuclear genomes is a cause of age-related physiological decline and that relocalization of chromatin factors in response to DNA breaks may be a cause of aging.
