Lifeboat Foundation

Scientists from Trinity College Dublin have discovered a new link between impaired brain energy metabolism and delirium—a disorienting and distressing disorder particularly common in the elderly and one that is currently occurring in a large proportion of patients hospitalized with COVID-19 [15th of July 2020].

While much of the research was conducted in mice, additional work suggests overlapping mechanisms are at play in humans because cerebrospinal fluid (CSF) collected from patients suffering from delirium also contained tell-tale markers of altered brain glucose metabolism.

Collectively, the research, which has just been published in the Journal of Neuroscience, suggests that therapies focusing on brain energy metabolism may offer new routes to mitigating delirium.

No industry will be spared.

The pharmaceutical business is perhaps the only industry on the planet, where to get the product from idea to market the company needs to spend about a decade, several billion dollars, and there is about 90% chance of failure. It is very different from the IT business, where only the paranoid survive but a business where executives need to plan decades ahead and execute. So when the revolution in artificial intelligence fueled by credible advances in deep learning hit in 2013–2014, the pharmaceutical industry executives got interested but did not immediately jump on the bandwagon. Many pharmaceutical companies started investing heavily in internal data science R&D but without a coordinated strategy it looked more like re-branding exercise with the many heads of data science, digital, and AI in one organization and often in one department. And while some of the pharmaceutical companies invested in AI startups no sizable acquisitions were made to date. Most discussions with AI startups started with “show me a clinical asset in Phase III where you identified a target and generated a molecule using AI?” or “how are you different from a myriad of other AI startups?” often coming from the newly-minted heads of data science strategy who, in theory, need to know the market.

However, some of the pharmaceutical companies managed to demonstrate very impressive results in the individual segments of drug discovery and development. For example, around 2018 AstraZeneca started publishing in generative chemistry and by 2019 published several impressive papers that were noticed by the community. Several other pharmaceutical companies demonstrated impressive internal modules and Eli Lilly built an impressive AI-powered robotics lab in cooperation with a startup.

Continue reading “Deep Dive Into Big Pharma AI Productivity: One Study Shaking The Pharmaceutical Industry” »

Scammers are everywhere now.

The defrauded bitcoin amassed during Wednesday’s monumental Twitter hack is already “on the move,” according to cryptocurrency tracing firm Chainalysis.

A star has been sent hurtling across the galaxy after undergoing a partial supernova, astronomers say.

A supernova is a powerful explosion that occurs when some stars reach the ends of their lives; in this case, the blast was not sufficient to destroy it.

Instead, it sent the star hurtling through space at 900,000 km/hr.

For the first time, scientists have determined the complete sequence of a human chromosome, namely the X chromosome, from ‘telomere to telomere’. This is truly a complete sequencing of a human chromosome, with no gaps in the base pair read and at an unprecedented level of accuracy.

A step closer towards the complete blueprint of a human being

The Human Genome Project was a 13-year-long, publicly funded project initiated in 1990 with the objective of determining the DNA sequence of the entire human genome.

A new study, published this week in The Lancet, concludes that the global population is likely to peak in 2064 at 9.7 billion and fall to 8.8 billion by century’s end. The report foresees major shifts in geopolitical power – producing a more multi-polar world – with 23 countries seeing their populations shrink by more than half as a result of declining fertility rates. Liberal immigration policies could help to maintain population sizes and economic growth, the authors suggest.

Golden Horde introduces swarm tactics to guided munitions—but it also lets the weapons make real decisions.

UK biotech valued at $500m will use public offering to move 5 life-extension technologies into phase 2 trials.

Japanese researchers have created a smart face mask that has a built in speaker and can translate speech into 8 different languages.

We live in a world full of technology but it was a world without smart masks, until now!

A Japanese technology company Donut Robotics has taken the initiative to create the first smart face masks which connects to your phone. Of course, we couldn’t have battled coronavirus with a simple mask that still does the job of protecting us perfectly well. We as a race need to bring technology into everything and more so if it does an array of extremely important, life-saving things like using a speaker to amplify a person’s voice, covert a person’s speech into text and then translate it into eight different languages through a smartphone app.