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Researchers of the Hubrecht Institute (KNAW) in Utrecht, The Netherlands, and the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, have discovered a new way in which the human body repairs DNA damage caused by a degradation product of alcohol. That knowledge underlines the link between alcohol consumption and cancer. The research groups of Puck Knipscheer and Ketan J. Patel worked together on this study and published the results in the scientific journal Nature on the 4th of March.

Our DNA is a daily target for a barrage of damage caused by radiation or toxic substances such as alcohol. When alcohol is metabolized, acetaldehyde is formed. Acetaldehyde causes a dangerous kind of DNA damage—the interstrand crosslink (ICL)—that sticks together the two strands of the DNA. As a result, it obstructs cell division and protein production. Ultimately, an accumulation of ICL damage may lead to cell death and cancer.

WUHAN (China Daily/ANN): With the public eagerly anticipating effective drugs to cure the novel coronavirus pneumonia, a medical ethics committee at the forefront of fighting the outbreak in Wuhan has quickened the pace of approving clinical trials.

Several programmes related to the diagnosis and treatment of the disease have gained ethical approval from Huazhong University of Science and Technology and are being carried out by the university, including two drugs that are under clinical trials, said Chen Jianguo, vice-president of the university.

The two drugs are remdesivir, a drug being developed by US-based pharmaceutical company Gilead, and chloroquine phosphate, which is available on the market to treat malaria.

Rutgers engineers have created a tabletop device that combines a robot, artificial intelligence and near-infrared and ultrasound imaging to draw blood or insert catheters to deliver fluids and drugs.

Their most recent research results, published in the journal Nature Machine Intelligence, suggest that autonomous systems like the image-guided robotic device could outperform people on some complex medical tasks.

Medical robots could reduce injuries and improve the efficiency and outcomes of procedures, as well as carry out tasks with minimal supervision when resources are limited. This would allow health care professionals to focus more on other critical aspects of medical care and enable emergency medical providers to bring advanced interventions and resuscitation efforts to remote and resource-limited areas.

The field of robotics took one step forward—followed by another, then several more—when a robot called Rainbow Dash recently taught itself to walk. The four-legged machine only required a few hours to learn to walk backward and forward, and turn right and left while doing so.

Researchers from Google, UC Berkeley and the Georgia Institute of Technology published a paper on the ArXiv preprint server describing a statistical AI technique known as deep reinforcement learning they used to produce this accomplishment, which is significant for several reasons.

Continue reading “Google’s robot learns to walk in real world” »

DARPA has established a new partnership with U.S. industry to jointly develop and deploy advanced robotic capabilities in space. The agency has signed an Other Transactions for Prototypes agreement with Space Logistics, LLC, a wholly-owned subsidiary of Northrop Grumman Corporation, as its commercial partner for the Robotic Servicing of Geosynchronous Satellites (RSGS) program.

The RSGS program’s objective is to create a dexterous robotic operational capability in geosynchronous orbit that can extend satellite life spans, enhance resilience, and improve reliability for current U.S. space infrastructure. The first step is the RSGS program’s development of a dexterous robotic servicer, which a commercial enterprise will then operate.

“DARPA remains committed to a commercial partnership for the execution of the RSGS mission,” said Dr. Michael Leahy, director of DARPA’s Tactical Technology Office. “Building upon the successes of the DARPA Orbital Express mission and the recent successful docking of Space Logistics’ Mission Extension Vehicle-1, the agency seeks to bring dexterous on-orbit servicing to spacecraft in geosynchronous orbit (GEO), and to establish that inspection, repair, life extension, and improvement of our valuable GEO assets can be made possible and even routine.”

Phase 3 of DARPA’s Operational Fires (OpFires) program began in earnest this month with government and contractor staff finalizing the system architecture approach, including a plan to use existing components from ground-launched missile systems, along with new booster technologies designed to support future hypersonic weapons. Lockheed Martin Missiles and Fire Control is leading the integration effort for the third phase of the program, which will focus on first stage booster design and maturation, launcher development, and vehicle integration.

Broad participation from the Army’s Combat Capabilities Development Command, range safety offices, and performers from OpFires Phase 2 propulsion teams contributed to success in the early, critical stages of the program. Since 2018, OpFires has made impressive strides developing and demonstrating advanced booster technologies that had never been used in prior systems. Phase 1 and 2 performers Aerojet Rocketdyne, Exquadrum, and Sierra Nevada Corporation continue work towards throttle-able upper stage rocket motors suitable for tactical transport, storage, and engagement.

“The objective of DARPA’s OpFires program is to deliver an intermediate-range surface-to-surface missile in line with the Department of Defense’s push to field hypersonic platforms,” said MAJ Amber Walker (USA), the DARPA program manager for OpFires.

Autonomous and semi-autonomous systems need active illumination to navigate at night or underground. Switching on visible headlights or some other emitting system like lidar, however, has a significant drawback: It allows adversaries to detect a vehicle’s presence, in some cases from long distances away.

To eliminate this vulnerability, DARPA announced the Invisible Headlights program. The fundamental research effort seeks to discover and quantify information contained in ambient thermal emissions in a wide variety of environments and to create new passive 3D sensors and algorithms to exploit that information.

“We’re aiming to make completely passive navigation in pitch dark conditions possible,” said Joe Altepeter, program manager in DARPA’s Defense Sciences Office. “In the depths of a cave or in the dark of a moonless, starless night with dense fog, current autonomous systems can’t make sense of the environment without radiating some signal—whether it’s a laser pulse, radar or visible light beam—all of which we want to avoid. If it involves emitting a signal, it’s not invisible for the sake of this program.”

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EXCLUSIVE: In a plot which seems straight out of the Netflix original series Altered Carbon, experts have told Daily Star Online the wealthy could soon achieve immortality.

Good dog :3.

Hank and Storm show Gray Hall how they do their jobs with the Philadelphia Police.

The dogs’ handlers, Officer Alvin Outlaw, who works with Storm, and Officer Richard Treston, who is paired with Hank, say it was the weeks of training and guidance that prepared them for the heavily wooded conditions that they encountered in Bucks County. Hank sniffed out the grave first and Storm followed up with the same results.

Continue reading “The cadaver dogs who helped crack a quadruple murder” »