Lifeboat Foundation

A group of researchers has demonstrated that treatment with NMN, a precursor of NAD+, restores neurovascular coupling (NVC) in aged mice [1]. Since NVC deficiency seems to be a major factor in the age-related decline of cognitive and motor functions, this discovery presents exciting new possibilities for longevity research.

Neurovascular coupling

While the human brain is the evolutionary advantage that brought us to where we are today, operating this machine requires considerable resources. Our cerebral blood flow (CBF) accounts for 15% of cardiac output and 20% of resting total oxygen consumption, even though the brain itself comprises just 2% of body mass. CBF has to be constantly redirected to the regions of the brain that are currently active, and NVC is the mechanism in charge of this complex operation. Importantly, the CBF/cardiac output ratio decreases with age [2].

Saudi Arabia hopes to build ties to Hollywood by investing in Beverly Hills-based Live Nation, which the coronavirus has brought to its knees.

The asteroid, dubbed 1998 OR2, is predicted to measure between 1.8 km — 4.1 km in diameter. At the higher end of that estimate, it means the space rock could be five times bigger than the Burj Khalifa.

In November of 2019—likely, even earlier—a tiny entity measuring just a few hundred billionths of a meter in diameter began to tear apart human society on a global scale. Within a few months, the relentless voyager known as SARS-CoV-2 had made its way to every populated corner of the earth, leaving scientists and health authorities with too many questions and few answers.

Today, researchers are scrambling to understand where and how the novel coronavirus arose, what features account for the puzzling constellation of symptoms it can cause and how the wildfire of transmission may be brought under control. An important part of this quest will involve efforts to properly classify this emergent human pathogen and to understand how it relates to other viruses we may know more about.

In a consensus statement, Arvind Varsani, a molecular virologist with ASU’s Biodesign Center for Fundamental and Applied Microbiomics and a host of international collaborators propose a new classification system, capable of situating coronaviruses like SARS-CoV-2 within the enormous web of viruses across the planet, known as the virosphere.

For most of the 20th century, astronomers have scoured the skies for supernovae—the explosive deaths of massive stars—and their remnants in search of clues about the progenitor, the mechanisms that caused it to explode, and the heavy elements created in the process. In fact, these events create most of the cosmic elements that go on to form new stars, galaxies, and life.

Because no one can actually see a supernova up close, researchers rely on supercomputer simulations to give them insights into the physics that ignites and drives the event. Now for the first time ever, an international team of astrophysicists simulated the three-dimensional (3D) physics of superluminous supernovae—which are about a hundred times more luminous than typical supernovae. They achieved this milestone using Lawrence Berkeley National Laboratory’s (Berkeley Lab’s) CASTRO code and supercomputers at the National Energy Research Scientific Computing Center (NERSC). A paper describing their work was published in Astrophysical Journal.

Astronomers have found that these superluminous events occur when a magnetar—the rapidly spinning corpse of a massive star whose magnetic field is trillions of times stronger than Earth’s—is in the center of a young supernova. Radiation released by the magnetar is what amplifies the supernova’s luminosity. But to understand how this happens, researchers need multidimensional simulations.

Now the company will mount a single engine to the Starship prototype.

Scientists believe the world will see it’s first working thermonuclear fusion reactor by the year 2025. That’s a tall order in short form, especially when you consider that fusion has been “almost here” for nearly a century.

Fusion reactors – not to be confused with common fission reactors – are the holiest of Grails when it comes to physics achievements. According to most experts, a successful fusion reactor would function as a near-unlimited source of energy.

In other words, if there’s a working demonstration of an actual fusion reactor by 2025, we could see an end to the global energy crisis within a few decades.

Central to a lot of scientific research into aging are tiny caps on the ends of our chromosomes called telomeres. These protective sequences of DNA grow a little shorter each time a cell divides, but by intervening in this process, researchers hope to one day regulate the process of aging and the ill health effects it can bring. A Harvard team is now offering an exciting pathway forward, discovering a set of small molecules capable of restoring telomere length in mice.

Telomeres can be thought of like the plastic tips on the end of our shoelaces, preventing the fraying of the DNA code of the genome and playing an important part in a healthy aging process. But each time a cell divides, they grow a little shorter. This sequence repeats over and over until the cell can no longer divide and dies.

This process is linked to aging and disease, including a rare genetic disease called dyskeratosis congenita (DC). This is caused by the premature aging of cells and is where the team focused its attention, hoping to offer alternatives to the current treatment that involves high-risk bone marrow transplants and which offers limited benefits.

Musk also tries to assure scientists his Starlink satellites won’t ruin the sky as many fear, and says he’d like to help send more observatories into orbit.