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Innovation in the amino-sciences for health, wellness, and aging — dr. tia rains phd, VP customer engagement & strategic development, ajinomoto.

Dr. Tia Rains, Ph.D., is Vice President of Customer Engagement & Strategic Development at Ajinomoto Health & Nutrition North America, Inc. (https://www.ajihealthandnutrition.com/), a division of Japanese food and biotechnology Ajinomoto Corporation (https://www.ajinomoto.com/), which produces seasonings, cooking oils, frozen foods, beverage, sweeteners, amino acids, and pharmaceuticals.

Dr. Rains has over 20 years of experience working on health and wellness initiatives within the food and beverage sector, and enjoys working at the intersection of nutrition research and communications, with the goal of advancing credible research in nutrition and developing truthful messaging on new research results in the context of the body of nutrition evidence.

Dr. Rains most recently headed up the Egg Nutrition Center (ENC) as it’s Executive Director.

Prior to joining ENC, Dr. Rains was the Senior Director of Metabolic Sciences at Biofortis Clinical Research, a global contract research organization specializing in the design and conduct of clinical research for leading food, beverage, and supplement companies around the world.

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SpaceX appears to have more or less broken ground on a new, even bigger ‘high bay’ assembly facility at its Boca Chica, Texas Starship factory.

Barely one year ago, SpaceX erected the first prefabricated steel sections of what eventually become its Starship factory ‘high bay’ – a spartan 81m (~265 ft) tall designed at the most basic level to shield final Starship and Super Heavy booster assembly from the elements. Situated near the southernmost tip of Texas and just a few miles west of the Gulf of Mexico, those “elements” can be less than pleasant at SpaceX’s primary Starship factory, ranging from sauna-like heat and humidity and mosquitoes the size of quarters to regular downpours, thunderstorms, tropical conditions, and even hurricanes.

While a great deal of work at Starbase is still done out in the open with little more than an umbrella as protection, SpaceX has nevertheless worked to find a middle ground where the most sensitive work (mainly structural welding) can be mostly shielded from wind and rain. First, SpaceX built a (relatively) tiny ‘windbreak’ too small for much of anything. Two years later, the windbreak is partially used for Starship nose section assembly – when a nose cone is stacked on and welded to a separate stack of four steel rings.

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Updated 11:45 p.m. to correct lunar orbit payload.

COLORADO SPRINGS — Japanese lunar space transportation company ispace is developing its design for a larger lunar lander that will be built in the United States.

The Tokyo-based company unveiled the design of the lander at the 36th Space Symposium Aug. 23. The lander, being developed by the company’s U.S. office in Denver, will fly as soon as2024on the company’s third mission to the moon.

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THE personal records of 38million people were accidentally leaked on the open internet due to a flaw in more than a thousand Microsoft web apps, according to reports.

American Airlines, Ford, J.B. Hunt, the Maryland Department of Health, the New York City Municipal Transportation Authority, and New York City public schools were among the companies and organizations affected by the mistake.

The data mistakenly shared online included information from a number of Covid-19 contact tracing platforms, vaccination sign-ups, job application portals, and employee databases, according to Wired.

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IBM has announced its new chip, Telum – a new CPU chip that will allow IBM clients to leverage deep learning inference at scale. The new chip features a centralised design, which allows clients to leverage the full power of the AI processor for AI-specific workloads, making it ideal for financial services workloads like fraud detection, loan processing, clearing and settlement of trades, anti-money laundering, and risk analysis.

A Telum-based system is planned for the first half of 2022. “Our goal is to continue improving AI hardware compute efficiency by 2.5 times every year for a decade, achieving 1,000 times better performance by 2029,” said IBM in a press release.

The chip contains eight processor cores, running with more than 5GHz clock frequency, optimised for the demands of enterprise-class workloads. The completely redesigned cache and chip-interconnection infrastructure provide 32MB cache per core. The chip also contains 22 billion transistors and 19 miles of wire on 17 metal layers.

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The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused a significant number of fatalities and worldwide disruption. To identify drugs to repurpose to treat SARS-CoV-2 infections, we established a screen to measure the dimerization of angiotensin-converting enzyme 2 (ACE2), the primary receptor for the virus. This screen identified fenofibric acid, the active metabolite of fenofibrate. Fenofibric acid also destabilized the receptor-binding domain (RBD) of the viral spike protein and inhibited RBD binding to ACE2 in enzyme-linked immunosorbent assay (ELISA) and whole cell-binding assays. Fenofibrate and fenofibric acid were tested by two independent laboratories measuring infection of cultured Vero cells using two different SARS-CoV-2 isolates. In both settings at drug concentrations, which are clinically achievable, fenofibrate and fenofibric acid reduced viral infection by up to 70%. Together with its extensive history of clinical use and its relatively good safety profile, this study identifies fenofibrate as a potential therapeutic agent requiring an urgent clinical evaluation to treat SARS-CoV-2 infection.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for a pandemic, which has cost over 1.9 million lives worldwide so far (Dhama et al., 2020; World Health Organization, 2020; Wu et al., 2020). The emergence of new virus variants with higher transmissibility rates is seeing rapid increases in infection rates and deaths across the world. Several vaccines have undergone accelerated approval and are being rolled out worldwide (Baden et al., 2021; Voysey et al., 2021). While the clinical data are very promising, the vaccines are not recommended or suitable in all patient groups, e.g., children, those with hyperimmune disorders, and those using immunosuppressants (Meo et al., 2021), and with the global spread of viral variants of concern, e.g., Alpha-B.1.1.7, Beta-B.1.351, Gamma-P.1, and Delta-B.1.617.2, it is presently unclear whether the current vaccines will offer sufficient protection to emerging strains (Meo et al., 2021).

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Drug delivery technologies have enabled the development of many pharmaceutical products that improve patient health by enhancing the delivery of a therapeutic to its target site, minimizing off-target accumulation and facilitating patient compliance. As therapeutic modalities expanded beyond small molecules to include nucleic acids, peptides, proteins and antibodies, drug delivery technologies were adapted to address the challenges that emerged. In this Review Article, we discuss seminal approaches that led to the development of successful therapeutic products involving small molecules and macromolecules, identify three drug delivery paradigms that form the basis of contemporary drug delivery and discuss how they have aided the initial clinical successes of each class of therapeutic. We also outline how the paradigms will contribute to the delivery of live-cell therapies.

This Review Article discusses how delivery challenges associated with small molecules, nucleic acids, peptides, proteins and cells led to the development of commercial products and are now informing the delivery of live-cell therapeutics.

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My story centers on the concept of a genetically modified virus (named) which infects the brain and gives people enhanced empathy. The narrative takes place in a fictional middle eastern city called Fakhoury and explores bioethical themes. Love acts as a central motif which ties the story together. Note that this piece will be available online for a limited time, after which you will need to pay for the magazine. I encourage you to check out my story!

Read Philosophy Ethics Short Stories with your friends, family, book club, and students. Each story comes with suggested discussion questions.

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Following the iconic first view of a fully integrated Starship stack during fit checks on the Orbital Launch Site (OLS) mount, both Ship 20 and Booster 4 are being prepared for testing ahead of the milestone orbital launch attempt. Ship 20 has returned to the launch site, taking up suborbital Pad B ahead of proof testing objectives, while Booster 4 is undergoing final closeout work inside the High Bay.

The pre-launch campaign is ongoing while SpaceX makes preemptive moves on the future, with modifications to future Starships designs and the preparations to increase production cadence with a second, much larger, High Bay.

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