Lifeboat Foundation

A new Northwestern University-led study is unfolding the mystery of how RNA molecules fold themselves to fit inside cells and perform specific functions. The findings could potentially break down a barrier to understanding and developing treatments for RNA-related diseases, including spinal muscular atrophy and perhaps even the novel coronavirus.

“RNA folding is a dynamic process that is fundamental for life,” said Northwestern’s Julius B. Lucks, who led the study. “RNA is a really important piece of diagnostic and therapeutic design. The more we know about RNA folding and complexities, the better we can design treatments.”

Using data from RNA-folding experiments, the researchers generated the first-ever data-driven movies of how RNA folds as it is made by cellular machinery. By watching their videos of this folding occur, the researchers discovered that RNA often folds in surprising, perhaps unintuitive ways, such as tying itself into knots—and then immediately untying itself to reach its final structure.

We are fascinated by machines that can control cars, compose symphonies, or defeat people at chess, Go, or Jeopardy! While more progress is being made all the time in artificial intelligence (AI), some scientists and philosophers warn of the dangers of an uncontrollable superintelligent AI. Using theoretical calculations, an international team of researchers, including scientists from the Center for Humans and Machines at the Max Planck Institute for Human Development, shows that it would not be possible to control a superintelligent AI. Their study is published in the Journal of Artificial Intelligence Research.

Suppose in the not-too-distant future that a research team builds an AI system with intelligence superior to that of humans, so it can learn independently. Connected to the Internet, the AI would have access to all of humanity’s data. It could replace existing programs and take control of all machines globally.

Would this produce a utopia or a dystopia? Would the AI cure cancer, bring about world peace, and prevent a climate disaster? Or would it destroy humanity and take over the Earth?

London, 15 January, 2021 — OneWeb, the Low Earth Orbit (LEO) satellite communications company jointly owned by the UK Government and Bharti Global, announced today that it has secured additional funding from SoftBank Group Corp. (“SoftBank”) and Hughes Network Systems LLC (“Hughes”), bringing OneWeb’s total funding to $1.4 billion. The capital raised to date positions the Company to be fully funded for its first-generation satellite fleet, totaling 648 satellites, by the end of 2022.

OneWeb’s mission is to deliver broadband connectivity worldwide to bridge the global Digital Divide by offering everyone, everywhere access including to the Internet of Things (IoT) future and a pathway to 5G. OneWeb’s LEO satellite system includes a network of global gateway stations and a range of user terminals for different customer markets capable of delivering affordable, fast, high-bandwidth and low-latency communications services. In December 2020, OneWeb launched 36 new satellites, built at its Airbus Joint Venture assembly plant in Florida, USA, bringing the Company’s total fleet to 110 satellites, all fully-functioning and benefitting from International Telecommunication Union spectrum priority.

Sunil Bharti Mittal, Executive Chairman of OneWeb, commented, “We are delighted to welcome the investment from SoftBank and Hughes. Both are deeply familiar with our business, share our vision for the future, and their commitment allows us to capitalise on the significant growth opportunity ahead for OneWeb. We gain from their experience and capabilities, as we deliver a unique LEO network for the world.”

HURRY. I’m getting old.

Recent advances in deep learning enabled the development of AI systems that outperform humans in many tasks and have started to empower scientists and physicians with new tools. In this Comment, we discuss how recent applications of AI to aging research are leading to the emergence of the field of longevity medicine.

Summary: While 40% of people with primary progressive aphasia have underlying Alzheimer’s disease, a new study suggests they may not develop the memory problems associated with Alzheimer’s.

Source: AAN

Primary progressive aphasia is a rare neurodegenerative condition characterized by prominent language problems that worsen over time. About 40% of people with the condition have underlying Alzheimer’s disease. But a new study has found that people with the condition may not develop the memory problems associated with Alzheimer’s disease. The study is published in the January 132021, online issue of Neurology.

Technique for trapped ions could lead to more reliable quantum computers.

The Federal Aviation Administration has released new and looser rules for flying drones over highly populated areas and at night, effectively laying a welcome mat for future aerial deliveries of takeout food, Amazon packages, prescription drugs — you name it.

Why it matters: While the prospect of Jetsons-style convenience with less street gridlock is tantalizing, there are still plenty of logistical hurdles, and it will take some time for cities to figure out how to manage low-altitude air traffic as routinely as they do today’s road traffic.

Driving the news: FAA rules — handed down late last month — will require drones flying over cities to use remote identification technology, so people on the ground can tell what they’re doing and who owns them.

A team of researchers affiliated with a host of institutions across Japan has found that inhibiting kidney-type glutaminase-dependent glutaminolysis in mice can lead to elimination of senescent cells. In their paper published in the journal Science, the group describes using RNA interference to look for enzymes that are required for senescent cell survival and subsequently inducing them to die. Christopher Pan and Jason Locasale, with the Duke University School of Medicine, have published a Perspectives piece in the same journal issue outlining research into glutamine and the role it played in the work done by the team in this new effort.

Cells are described as senescent when they lose the ability to divide. Prior research has found that cells can reach senescence due to exposure to stress, which can include mitochondrial, replicative or oxidative stress. In all cases, the cells live and continue to function, but can no longer divide. Prior research has found evidence suggesting that senescent cells play a role in the development of some aging-related diseases such as arteriosclerosis and muscle degeneration. For that reason, scientists have been looking for ways to eliminate them. In this new effort, the researchers have found a way to rid test mice of senescent cells by removing a pathway necessary for their continued survival.

The work involved a screening effort using RNA interference to look for enzymes that senescent cells need to survive. This led them to look closer at glutamine metabolism, specifically glutaminase 1. Testing showed it to be critical to survival for senescent cells. The team then inhibited the glutaminase 1 pathway in test mice. After allowing time for the changes to take effect, the researchers found that inhibiting the pathway led to the deaths of senescent cells. In the longer term, they found that it also reduced age-related organ problems and also health issues related to obesity.

It’s good that they’re finally looking at the science.

The New York Times is now noting that “once most adults are immune — following natural infection or vaccination” the virus will enter its endemic phase and corona “will be no more of a threat than the common cold, according to a study published in the journal Science on Tuesday.”

Once immunity is widespread in adults, the virus rampaging across the world will come to resemble the common cold, scientists predict.

Continue reading “Even the NY Times is Noting That: The Future of the Coronavirus? An Annoying Childhood Infection!” »