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In this study we aimed to generate mouse antibodies against epitopes found on NPCs. We isolated one antibody (NSC-6) and characterized it in detail. Mass spectrometry using human hippocampal tissue revealed the identity of the recognized antigen as BASP1, a signaling protein that plays a key role in neurite outgrowth and plasticity14,15,16,17,18,19, but here, we demonstrate that it might be utilized as a marker of NSCs in the adult brain.

Similar approaches to developing antibodies against mouse embryonic stem cells have been attempted in the past utilizing mice46,47 and rabbits48. Major drawbacks in mice include immune tolerance to mouse embryonic stem cell surface antigens leading to low antibody production, which could be overcome by immunizing rabbits instead. Regardless of the animal used as a host, a significant number of antibodies are typically generated against intracellular epitopes when animals are immunized with whole cells as was observed in our study.

We found that NSC-6-labeled BASP1 localizes to all radial glia at the E12 stage of brain development, while postnatally, it restricts to the neurogenic areas of the mouse brain but not the cortex. This expression pattern contrasts previous study using DAB-based immunolabeling for NAP-22 (BASP1 alias) in the adult rat brain, which demonstrated robust labeling of cerebral cortex27. While we do not know the basis of this difference in immunolabeling of cortex, possibilities include species variations between rat and mouse expression of BASP1, or differences in epitope recognition between the two antibodies used that could yield distinct patterns of immunoreactivity. Indeed, the two commercial BASP1 polyclonal antibodies did not immunolabel NSCs and in general, exhibited poor staining of the mouse brain tissue.

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The European Union is finalizing plans for an ambitious “digital twin” of planet Earth that would simulate the atmosphere, ocean, ice, and land with unrivaled precision, providing forecasts of floods, droughts, and fires from days to years in advance. Destination Earth, as the effort is called, won’t stop there: It will also attempt to capture human behavior, enabling leaders to see the impacts of weather events and climate change on society and gauge the effects of different climate policies.

“It’s a really bold mission, I like it a lot,” says Ruby Leung, a climate scientist at the U.S. Department of Energy’s (DOE’s) Pacific Northwest National Laboratory. By rendering the planet’s atmosphere in boxes only 1 kilometer across, a scale many times finer than existing climate models, Destination Earth can base its forecasts on far more detailed real-time data than ever before. The project, which will be described in detail in two workshops later this month, will start next year and run on one of the three supercomputers that Europe will deploy in Finland, Italy, and Spain.

Destination Earth rose out of the ashes of Extreme Earth, a proposal led by the European Centre for Medium-Range Weather Forecasts (ECMWF) for a billion-euro flagship research program. The European Union ultimately canceled the flagship program, but retained interest in the idea. Fears that Europe was falling behind China, Japan, and the United States in supercomputing led to the European High-Performance Computing Joint Undertaking, an €8 billion investment to lay the groundwork for eventual “exascale” machines capable of 1 billion billion calculations per second. The dormant Extreme Earth proposal offered a perfect use for such capacity. “This blows a soul into your digital infrastructure,” says Peter Bauer, ECMWF’s deputy director of research, who coordinated Extreme Earth and has been advising the European Union on the new program.

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As the Times reports, researchers have been puzzling over the age of the Shigir sculpture for decades. The debate has major implications for the study of prehistory, which tends to emphasize a Western-centric view of human development.

In 1997, Russian scientists carbon-dated the totem pole to about 9500 years ago. Many in the scientific community rejected these findings as implausible: Reluctant to believe that hunter-gatherer communities in the Urals and Siberia had created art or formed cultures of their own, says Terberger to the Times, researchers instead presented a narrative of human evolution that centered European history, with ancient farming societies in the Fertile Crescent eventually sowing the seeds of Western civilization.

Prevailing views over the past century, adds Terberger, regarded hunter-gatherers as “inferior to early agrarian communities emerging at that time in the Levant. At the same time, the archaeological evidence from the Urals and Siberia was underestimated and neglected.”

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Circa 2018

In just a few weeks, NASA is due to launch one of its most ambitious projects yet. The Parker Solar Probe is going to swoop in and ‘touch’ the Sun — coming in closer to the solar surface than any probe has ever done before.

Parker’s three closest orbits will bring it within 6.1 million kilometres (3.8 million miles) of the Sun’s surface and inside its outer atmosphere, or corona, where temperatures reach millions of degrees Kelvin.

It does have heat shielding, and it’s actually pretty wicked, but we’ll get into that later. Because first, we have to address those searing temperatures.

Continue reading “Here’s How NASA’s Solar Probe Is Going to Touch The Sun Without Melting” | >

Phosphorus, the element critical for life´s origin and life on Earth, may be even Venus.

Scientists studying the origin of life in the universe often focus on a few critical elements, particularly carbon, hydrogen, and oxygen. But two new papers highlight the importance of phosphorus for biology: an assessment of where things stand with a recent claim about possible life in the clouds of Venus, and a look at how reduced phosphorus compounds produced by lightning might have been critical for life early in our own planet’s history.

First a little biochemistry: Phosphine is a reduced phosphorus compound with one phosphorus atom and three hydrogen atoms. Phosphorus is also found in its reduced form in the phosphide mineral schreibersite, in which the phosphorus atom binds to three metal atoms (either iron or nickel). In its reduced form, phosphorus is much more reactive and useful for life than is phosphate, where the phosphorus atom binds to four oxygen atoms. Phosphorus is also the element that is most enriched in biological molecules as compared to non-biological molecules, so it’s not a bad place to start when you’re hunting for life.

In the second of the new papers, Benjamin Hess from Yale University and colleagues highlight the contribution of lightning as a source of reduced phosphorus compounds such as schreibersite. It has long been recognized that meteorites supplied much of the reduced phosphorus needed for the origin of life on Earth. But Hess thinks the contribution of lightning has been underestimated. For one thing, lightning was much more common early in our planet’s history. The authors calculate that it could have produced up to 10000 kilograms of reduced phosphorus compounds per year—which may have been enough to jump-start life, especially because we don’t know how much of the reduced phosphorus from meteorites actually survives (in that form) the impact on Earth.

Continue reading “The Fuss Over Phosphorus” | >