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“I realized that in the middle-dose group, which is the one that mattered for the no-effects level, they had conveniently left out one of the two baseline measurement days,” said Sheppard. “The outrageous thing was that the group they declared as NOEL was only that because they left out data from their analysis.” In a peer-reviewed paper published in October 2020, Sheppard and her colleagues concluded that “the omission of valid data without justification was a form of data falsification.”


In any case, bifenthrin was not the only pesticide that dodged testing to see if it presented dangers. The EPA’s pesticide office granted 972 industry requests to waive toxicity tests between December 2011 and May 2018, 89 percent of all requests made. Among the tests on pesticides that were never performed were 90 percent of tests looking for developmental neurotoxicity, 92 percent of chronic cancer studies, and 97 percent of studies looking at how pesticides harm the immune system.

By law, the companies that submit their products for review pay for these tests, and in a presentation about the waivers last year, Anna Lowit, a senior science adviser in the office, emphasized the savings to these companies: more than $300 million. Lowit also noted that animal lives were saved — a goal that the Trump administration and the chemical industry prioritized within the agency. The EPA developed the guidelines for waiving the tests along with BASF, Corteva, and Syngenta, pesticide manufacturers that all stand to benefit significantly from having their products bypass toxicity testing.

There is no replacement for these waived experiments, according to pediatrician and epidemiologist Philip Landrigan. “There is no other way to know if a chemical is toxic but to test it,” said Landrigan, who co-authored a landmark report on children’s particular vulnerability to pesticides. “If they allow chemicals to come onto the market and to be used widely in the environment and put on food crops without testing them for toxicity, then EPA is clearly not fulfilling its mandate to protect human health.”

Not everything that is true can be proven. This discovery transformed infinity, changed the course of a world war and led to the modern computer. This video is sponsored by Brilliant. The first 200 people to sign up via https://brilliant.org/veritasium get 20% off a yearly subscription.

Special thanks to Prof. Asaf Karagila for consultation on set theory and specific rewrites, to Prof. Alex Kontorovich for reviews of earlier drafts, Prof. Toby ‘Qubit’ Cubitt for the help with the spectral gap, to Henry Reich for the helpful feedback and comments on the video.

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References:

Dunham, W. (2013, July). A Note on the Origin of the Twin Prime Conjecture. In Notices of the International Congress of Chinese Mathematicians (Vol. 1, No. 1, pp. 63–65). International Press of Boston. — https://ve42.co/Dunham2013

Not just the results, but the vector used. I’ll post the paper below.


In this video we cover an experiment where gene therapies to overexpress TERT and Follistatin were used in a mouse model. The mice saw a 41 and 32% increase in median life span. The study also used a novel viral vector, cytomegalovirus for the delivery. Please note that this a preprint which is not peer-reviewed yet.

Papers referred to in this newsletter.

New research shows how the fundamental law of conservation of charge could break down near a black hole.

Singularities, such as those at the centre of black holes, where density becomes infinite, are often said to be places where physics ‘breaks down’. However, this doesn’t mean that ‘anything’ could happen, and physicists are interested in which laws could break down, and how.

Now, a research team from Imperial College London, the Cockcroft Institute and Lancaster University have proposed a way that singularities could violate the law of conservation of charge. Their theory is published in Annalen der Physik.

Wally Funk was one of 13 female aviators who lobbied for women to become astronauts in the early days of spaceflight.


Aviator Wally Funk wanted to be an astronaut in the earliest days of spaceflight. Sixty years later, on July 20, she’ll finally go to space with Blue Origin.

Funk was one of 13 female aviators later dubbed the Mercury 13 who, in 1961, passed all the exams necessary for admission to NASA’s astronaut corps and lobbied the federal government to send women into space. NASA and Congress demurred and women were excluded from becoming U.S. astronauts for more than a decade; Sally Ride became the first American woman to fly in space in 1983.

Antiaging gene therapies to overexpress TERT and Follistatin were used in a mouse model. The mice saw a 41 and 32% increase in median life span. The study also used a novel viral vector, cytomegalovirus for the delivery.

Liz Parish of Bioviva has treated herself with all of these antiaging gene therapies.

If humans experienced the same antiaging effect as the mice then humans would live to a median age of 100 with these treatments.

Researchers have created an unusual new alloy made up of not two, but five different metals, and put it to work as a catalyst. The new material is two-dimensional, and was able to convert carbon dioxide into carbon monoxide effectively, potentially helping to turn the greenhouse gas into fuels.

The new alloy belongs to a class of materials called transition metal dichalcogenides (TMDCs), which are, as the name suggests, made up of combinations of transition metals and chalcogens. Extremely thin films of TMDCs have recently shown promise in a range of electronic and optical devices, but researchers on the new study wondered if they could also be used as catalysts for chemical reactions.

The thinking goes that because reactions occur on the surface of a catalyst, materials with high surface areas will be more effective catalysts. And as sheets only a few atoms thick, TMDCs are almost nothing but surface area.