Lifeboat Foundation: Safeguarding Humanity
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Sleep, fasting, exercise, green porridge, black coffee, a healthy social life—there is an abundance of advice out there on how to live a good, long life. Researchers are working hard to determine why some people live longer than others, and how we get the most out of our increasingly long lives.

Now researchers from the Center for Healthy Aging, Department of Cellular and Molecular Medicine at the University of Copenhagen have discovered that a particular protein known as OSER1 has a great influence on longevity. The research is published in the journal Nature Communications.

“We identified this protein that can extend longevity. It is a novel pro-longevity factor, and it is a protein that exists in various animals, such as fruit flies, nematodes, silkworms, and in humans,” says Professor Lene Juel Rasmussen, senior author behind the new study.

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Macroautophagy (hereafter autophagy) is a cellular recycling process that degrades cytoplasmic components, such as protein aggregates and mitochondria, and is associated with longevity and health in multiple organisms. While mounting evidence supports that autophagy declines with age, the underlying molecular mechanisms remain unclear. Since autophagy is a complex, multistep process, orchestrated by more than 40 autophagy-related proteins with tissue-specific expression patterns and context-dependent regulation, it is challenging to determine how autophagy fails with age. In this review, we describe the individual steps of the autophagy process and summarize the age-dependent molecular changes reported to occur in specific steps of the pathway that could impact autophagy.

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A new device at the University of Central Florida captures carbon dioxide and turns it into useful products.

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It’s 7 billion years ago, and the universe’s heyday of star formation is beginning to slow. What might our Milky Way galaxy have looked like at that time? Astronomers using NASA’s James Webb Space Telescope have found clues in the form of a cosmic question mark, the result of a rare alignment across light-years of space.

“We know of only three or four occurrences of similar gravitational lens configurations in the observable universe, which makes this find exciting, as it demonstrates the power of Webb and suggests maybe now we will find more of these,” said astronomer Guillaume Desprez of Saint Mary’s University in Halifax, Nova Scotia, a member of the team presenting the Webb results.

While this region has been observed previously with NASA’s Hubble Space Telescope, the dusty red galaxy that forms the intriguing question-mark shape only came into view with Webb. This is a result of the wavelengths of light that Hubble detects getting trapped in cosmic dust, while longer wavelengths of infrared light are able to pass through and be detected by Webb’s instruments.

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O.o!!!

The lack of water was particularly impacting Indigenous communities who depend on the river for food and transport, it added.

AFP has observed boats stranded around Leticia, capital of the southern Amazonas state, in recent days, with large swathes of land exposed by low water levels.

The city, near the borders with Brazil and Peru, is a critical trading post along the Amazon River.

Continue reading “Drought reduces Amazon River in Colombia by as much as 90%: report” | >

Her initial workup revealed enlarged mediastinal nodes, bilateral ground glass interstitial opacities with areas of septal thickening, an incidental 4-cm left lower lobe nodular mass, multiple hypermetabolic lesions in the liver (the largest was 2.8 cm with a standard uptake value of 43), and osseous metastatic disease.

Ultrasound-guided biopsy showed poorly differentiated metastatic lung adenocarcinoma (stage 4) with 5% tumor cells expressing PD-L1 and negative for EGFR/ALK gene alterations.

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Artificial intelligence start-ups are making revenues more quickly than previous waves of software companies, according to new data that suggests that the transformative technology is also generating strong businesses at an unprecedented rate.

According to an analysis of payments information from fintech group Stripe, top AI groups are reaching millions of dollars in sales within a year — far faster in a start-up’s life cycle than comparable non-AI tech groups.

The findings come as investors raise questions about the economic benefits of generative AI and likely returns on Big Tech’s projected trillion-dollar investment in computing infrastructure to support the technology over the coming year.

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