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Researchers from the group of Hans Clevers (Hubrecht Institute) corrected mutations that cause cystic fibrosis in cultured human stem cells. In collaboration with the UMC Utrecht and Oncode Institute, they used a technique called prime editing to replace the ‘faulty’ piece of DNA with a healthy piece. The study, published in Life Science Alliance on August 9 shows that prime editing is safer than the conventional CRISPR/Cas9 technique. “We have for the first time demonstrated that this technique really works and can be safely applied in human stem cells to correct cystic fibrosis.”

Cystic fibrosis (CF) is one of the most prevalent genetic diseases worldwide and has grave consequences for the patient. The mucus in the lungs, throat and intestines is sticky and thick, which causes blockages in organs. Although treatments are available to dilute the mucus and prevent inflammations, CF is not yet curable. However, a new study from the group of Hans Clevers (Hubrecht Institute) in collaboration with the UMC Utrecht and Oncode Institute offers new hope.

Correcting CF mutations

The researchers succeeded in correcting the that cause CF in human intestinal organoids. These organoids, also called mini-organs, are tiny 3D structures that mimic the intestinal function of patients with CF. They were previously developed by the same research group from stem cells of patients with CF and stored in a biobank in Utrecht. For the study, published in Life Science Alliance, a technique named prime editing was used to replace the piece of mutated DNA that causes CF with a healthy piece of DNA in these organoids.

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Caffeinated coffee might be protective to overall health, but so is decaf. For example, a 2,019 systematic review published in the Journal of Human Nutrition and Dietetics aiming to “investigate the association of caffeinated and decaffeinated coffee consumption and all-cause mortality” found “similar inverse associations [between] caffeinated coffee and decaffeinated coffee [and all-cause mortality.]”

But is coffee healthy? And do coffee drinkers live longer than non-coffee drinkers?

At the turn of the 20th century, it was considered common knowledge that coffee was unhealthy—there were advertising claims that coffee drinking caused blindness and that “you can recover from any ordinary disease by discontinuing coffee.” And while that may obviously be untrue, there are continuing fears about whether coffee is actually healthy or not. Google receives 4,400 queries a month about” why coffee is bad for you” (for context, “why coffee is good for you” gets only 1,300 queries a month).

So with human life extension in mind, I decided to dig into the research. Can coffee consumption actually help spanners extend their healthspan and lifespan? How much is the right dose? How much is too little?

Continue reading “Do Coffee Drinkers Live Longer?” | >

For several years, Lu’s lab has been working on ways to use DNA to store information such as memory of cellular events. In 2,014 he and Farzadfard developed a way to employ bacteria as a “genomic tape recorder,” engineering E. coli to store long-term memories of events such as a chemical exposure.

Technique for editing bacterial genomes can record interactions between cells, may offer a way to edit genes in the human microbiome.

Biological engineers at MIT

MIT is an acronym for the Massachusetts Institute of Technology. It is a prestigious private research university in Cambridge, Massachusetts that was founded in 1861. It is organized into five Schools: architecture and planning; engineering; humanities, arts, and social sciences; management; and science. MIT’s impact includes many scientific breakthroughs and technological advances.

Continue reading “MIT Researchers Devised a Way To Program Memories Into Bacterial Cells” | >

The possible impact of heavy peanut consumption by cancer patients on survival will need to be investigated in further population-based epidemiological studies.

Summary: A new study reports cancer patients who frequently eat peanuts may be at increased risk of their cancer spreading. Researchers found Peanut agglutinin (PNA), a carbohydrate-binding protein that enters blood circulation after a peanut is eaten, interacts with endothelial cells to produce cytokines. Some of the cytokines are recognized promoters of cancer metastasis.

Source: University of Liverpool

A study by University of Liverpool researchers has identified new factors accompanying previous findings that frequent consumption of peanuts by cancer patients could increase risk of cancer spread.

Continue reading “Frequent Peanut Consumption May Increase Cancer Spread in Patients” | >

SpaceX achieved another milestone this week as the Starship and Super Heavy prototype were stacked and fully-integrated for the first time!

Once again, things are gearing up at SpaceX’s South Texas Launch Facility, located just outside the village of Boca Chica, Texas. In recent weeks, the aerospace community has been abuzz about the rollout and Static Fire test of the Super Heavy Booster 3 (B3) prototype. This was the first time a booster was tested, which will be responsible for launching the Starship to space in the near future. Since then, things have only ramped up some more.

First, there was the announcement on Aug. 2nd that the fourth Super Heavy prototype (the BN4) received a full complement of 29 Raptor engines and grid fins. This was followed on Aug. 3rd with news that BN4 was being moved to the launch pad and that the SN20 Starship prototype received a full six Raptor engines. On Aug. 6th, the denouement came with the stacking of both prototypes together, which resulted in the tallest rocket in the history of spaceflight!

Together, the integrated Starship stood around 120 meters (390 feet) tall, while the addition of the orbital launch stand increased that to 145 m (475 feet) – which is taller than the Pyramid of Giza (138.5 m; 454 ft). The stacking was the first time that the Starship and Super Heavy were fully integrated, a major milestone for the company that puts them one step closer to making an orbital flight test.

Continue reading “Starship is Stacked on the Super Heavy Booster. The Tallest Rocket Ever Built” | >