Lifeboat Foundation

Good talk, not just about NAD. Q&A just before 35 minutes. A lot of epigenetics here.

David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years. His research has been primarily focused on the sirtuins, protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. The Sinclair lab was the first one to identify a role for NAD+ biosynthesis in regulation of lifespan and first showed that sirtuins are involved in CR in mammals. They first identified small molecules that activate SIRT1 such as resveratrol and studied how they improve metabolic function using a combination of genetic, enzymological, biophysical and pharmacological approaches. They recently showed that natural and synthetic activators require SIRT1 to mediate the in vivo effects in muscle and identified a structured activation domain. They demonstrated that miscommunication between the mitochondrial and nuclear genomes is a cause of age-related physiological decline and that relocalization of chromatin factors in response to DNA breaks may be a cause of aging.

Ever wondered how do we communicate with space? Watch yourself.

#SpaceExploration

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Data governs our lives more than ever. But when it comes to disease and death, every data point is a person, someone who became sick and needed treatment.

Recent studies have revealed that people suffering from the same disease category may have different manifestations. As doctors and scientists better understand the reasons underlying this variability, they can develop novel preventive, diagnostic and therapeutic approaches and provide optimal, personalized care for every patient.

To accomplish this goal often requires broadscale collaborations between physicians, basic researchers, theoreticians, experimentalists, computational biologists, computer scientists and data scientists, engineers, statisticians, epidemiologists and others. They must work together to integrate scientific and medical knowledge, theory, analysis of medical big data and extensive experimental work.

Continue reading “Israeli researchers explain how they are healing the world with precision” »

“Now, nearly 2,000 people in and around Leticia are sick with COVID-19. About 70 have died. That might not sound like a colossal death toll at first. But because the surrounding state of Amazonas is sparsely populated, this amounts to the highest per-capita death rate in all of Colombia, according to figures from Colombia’s Health Ministry.”

The governor of Amazonas, Colombia, says it was impossible to cut the area off from Brazil, even as the virus spiked. Now the Colombian border town of Leticia is a coronavirus hot spot.

Continue reading “The Coronavirus Is Spreading Through Indigenous Communities In The Amazon” »

Like most galaxies, the Milky Way hosts a supermassive black hole at its center. Called Sagittarius A*, the object has captured astronomers’ curiosity for decades. And now there is an effort to image it directly.

Catching a good photo of the celestial beast will require a better understanding of what’s going on around it, which has proved challenging due to the vastly different scales involved. “That’s the biggest thing we had to overcome,” said Sean Ressler, a postdoctoral researcher at UC Santa Barbara’s Kavli Institute for Theoretical Physics (KITP), who just published a paper in the Astrophysical Journal Letters, investigating the magnetic properties of the accretion disk surrounding Sagittarius A*.

In the study, Ressler, fellow KITP postdoc Chris White and their colleagues, Eliot Quataert of UC Berkeley and James Stone at the Institute for Advanced Study, sought to determine whether the black hole’s magnetic field, which is generated by in-falling matter, can build up to the point where it briefly chokes off this flow, a condition scientists call magnetically arrested. Answering this would require simulating the system all the way out to the closest orbiting stars.

J&J Chief Scientific Officer Dr. Paul Stoffels says the vaccine being produced needs a minimum 70% efficacy to be considered successful.

A team of scientists, including Chief Investigator Ilya Mandel from the ARC Centre of Excellence for Gravitational Wave Discovery (OzGrav) at Monash University, recently studied what happens to rotating massive stars when they reach the end of their lives.

Stars produce energy by fusing lighter elements into heavier ones in their core: hydrogen into helium, then helium into carbon, oxygen, and so on, up to iron. The energy produced by this nuclear fusion also provides pressure support inside the star, which balances the force of gravity and allows the star to remain in equilibrium.

This process stops at iron. Beyond iron, energy is required to sustain fusion rather than being released by fusion. A heavy iron star core contracts under gravity, creating a neutron star, or if it is heavy enough, a black hole. Meanwhile, the outer layers of the star explode in a brilliant flash, observable as a supernova. However, some massive stars seem to completely disappear without any explosion. Theories suggest that these massive stars completely collapse into black holes, but is that possible?

Radio waves travel poorly through the water, which makes it difficult for divers or submersibles to wirelessly transmit information to the surface. Scientists are trying to change that, though, by developing an underwater version of Wi-Fi.

Back in 2018, we heard how researchers at Saudi Arabia’s King Abdullah University of Science and Technology (KAUST) had used lasers to transmit HD video through water. Their experimental new system, known as Aqua-Fi, builds on that technology.

A user such as a scuba diver would start by sending data (such as photos or videos) from a smartphone contained in a watertight housing. That data would initially be transmitted in the form of radio waves, going just a few feet to a small device mounted on the diver’s air tanks.