Lifeboat Foundation

Yes this says a 3 year epigenetic clock reversal in just 8 weeks thanks to diet and lifestyle changes. There is a list of supplements too:

Alpha ketoglutarate, vitamin C and vitamin A curcumin, epigallocatechin gallate (EGCG), rosmarinic acid, quercetin, luteolin.

Manipulations to slow biological aging and extend healthspan are of interest given the societal and healthcare costs of our aging population. Herein we report on a randomized controlled clinical trial conducted among 43 healthy adult males between the ages of 50–72. The 8-week treatment program included diet, sleep, exercise and relaxation guidance, and supplemental probiotics and phytonutrients. The control group received no intervention. Genome-wide DNA methylation analysis was conducted on saliva samples using the Illumina Methylation Epic Array and DNAmAge was calculated using the online Horvath DNAmAge clock (2013). The diet and lifestyle treatment was associated with a 3.23 years decrease in DNAmAge compared with controls (p=0.018). DNAmAge of those in the treatment group decreased by an average 1.96 years by the end of the program compared to the same individuals at the beginning with a strong trend towards significance (p=0.066). Changes in blood biomarkers were significant for mean serum 5-methyltetrahydrofolate (+15%, p=0.004) and mean triglycerides (−25%, p=0.009). To our knowledge, this is the first randomized controlled study to suggest that specific diet and lifestyle interventions may reverse Horvath DNAmAge (2013) epigenetic aging in healthy adult males. Larger-scale and longer duration clinical trials are needed to confirm these findings, as well as investigation in other human populations.

Continue reading “Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial” »

NASA’s Ingenuity helicopter takes an aerial photo that let’s viewers hunt for the Perseverance rover on the ground as the rover itself hunts for ancient life.

Engineers at Caltech and JPL

The Jet Propulsion Laboratory (JPL) is a federally funded research and development center managed for NASA by the California Institute of Technology (Caltech). The laboratory’s primary function is the construction and operation of planetary robotic spacecraft, though it also conducts Earth-orbit and astronomy missions. It is also responsible for operating NASA’s Deep Space Network. JPL implements programs in planetary exploration, Earth science, space-based astronomy and technology development, while applying its capabilities to technical and scientific problems of national significance.

Synopsys, which sells software for designing semiconductors to dozens of companies, is adding artificial intelligence to its arsenal.

Artificial intelligence research company OpenAI has announced the development of an AI system that translates natural language to programming code—called Codex, the system is being released as a free API, at least for the time being.

Codex is more of a next-step product for OpenAI, rather than something completely new. It builds on Copilot, a tool for use with Microsoft’s GitHub code repository. With the earlier product, users would get suggestions similar to those seen in autocomplete in Google, except it would help finish lines of code. Codex has taken that concept a huge step forward by accepting sentences written in English and translating them into runnable code. As an example, a user could ask the system to create a web page with a certain name at the top and with four evenly sized panels below numbered one through four. Codex would then attempt to create the page by generating the code necessary for the creation of such a site in whatever language (JavaScript, Python, etc.) was deemed appropriate. The user could then send additional English commands to build the website piece by piece.

Codex (and Copilot) parse written text using OpenAI’s language generation model—it is able to both generate and parse code, which allowed users to use Copilot in custom ways—one of those ways was to generate programming code that had been written by others for the GitHub repository. This led many of those who had contributed to the project to accuse OpenAI of using their code for profit, a charge that could very well be levied against Codex, as well, as much of the code it generates is simply copied from GitHub. Notably, OpenAI started out as a nonprofit entity in 2,015 and changed to what it described as a “capped profit” entity in 2019—a move the company claimed would help it get more funding from investors.

Houston-based ThirdAI, a company building tools to speed up deep learning technology without the need for specialized hardware like graphics processing units, brought in $6 million in seed funding.

Neotribe Ventures, Cervin Ventures and Firebolt Ventures co-led the investment, which will be used to hire additional employees and invest in computing resources, Anshumali Shrivastava, Third AI co-founder and CEO, told TechCrunch.

Shrivastava, who has a mathematics background, was always interested in artificial intelligence and machine learning, especially rethinking how AI could be developed in a more efficient manner. It was when he was at Rice University that he looked into how to make that work for deep learning. He started ThirdAI in April with some Rice graduate students.

An analysis of one of Stonehenge’s sandstone sarsens shows the boulder is made up of interlocking rock crystals that make it almost indestructible.

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It’s hard to avoid garbage when you’re chemically attracted to it. But such is the life of a hermit crab.