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Incredible new videos show stem cells escaping from hair follicles, which could provide insight on a new, potentially reversible mechanism of hair loss.

Stem cells contribute to tissue regeneration, and they are thought to play an important role in age-related decline — so much so that stem cell exhaustion is one of the hallmarks of aging. These stem cells reside in “compartments” in various tissues. In the hair, the stem cell compartment, known as the bulge, is adjacent to the hair follicle.

It is extremely hard to monitor stem cell activity in live animals over time, yet this is exactly what the researchers of this study have achieved using noninvasive imaging techniques based on lasers. By anesthetizing mice and putting them inside the imaging device, they were able to observe and record the process of stem cells escaping their compartment.

Researchers watched as escaping stem cells changed their shape and shot out of the compartment as if squeezing through invisible holes, which are most likely structural abnormalities in the membrane. The researchers hypothesize that aging somehow harms the structural integrity of the membrane, but this phenomenon demands further examination. The “rogue” stem cells escape to the dermis, which is the lower layer of the skin. Once there they remained stem cells, and seemed to be doing quite well in the new environment. However, this may not be a good sign, since stem cells are known to contribute heavily to tumorigenesis, and the authors call for more research into the role that escaping stem cells might play in the development of cancer.

Continue reading “Hair Loss Reversal? Stem Cell Escape Identified!” | >

The creation of nanoscale computers for use in precision health care has long been a dream of many scientists and health care providers. Now, for the first time, researchers at Penn State have produced a nanocomputing agent that can control the function of a particular protein that is involved in cell movement and cancer metastasis. The research paves the way for the construction of complex nanoscale computers for the prevention and treatment of cancer and other diseases.

Nikolay Dokholyan, G. Thomas Passananti Professor, Penn State College of Medicine, and his colleagues — including Yashavantha Vishweshwaraiah, postdoctoral scholar in pharmacology, Penn State — created a transistor-like ‘logic gate,’ which is a type of computational operation in which multiple inputs control an output.

“Our logic gate is just the beginning of what you could call cellular computing,” he said, “but it is a major milestone because it demonstrates the ability to embed conditional operations in a protein and control its function, said Dokholyan. ” It will allow us to gain a deeper understanding of human biology and disease and introduces possibilities for the development of precision therapeutics.”

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By Watching Unlabeled Videos.

Recent advances in machine learning (ML) and artificial intelligence (AI) are increasingly being adopted by people worldwide to make decisions in their daily lives. Many studies are now focusing on developing ML agents that can make acceptable predictions about the future over various timescales. This would help them anticipate changes in the world around them, including the actions of other agents, and plan their next steps. Making judgments require accurate future prediction necessitates both collecting important environmental transitions and responding to how changes develop over time.

Previous work in visual observation-based future prediction has been limited by the output format or a manually defined set of human activities. These are either overly detailed and difficult to forecast, or they are missing crucial information about the richness of the real world. Predicting “someone jumping” does not account for why they are jumping, what they are jumping onto, and so on. Previous models were also meant to make predictions at a fixed offset into the future, which is a limiting assumption because we rarely know when relevant future states would occur.

A new Google study introduces a Multi-Modal Cycle Consistency (MMCC) method, which uses narrated instructional video to train a strong future prediction model. It is a self-supervised technique that was developed utilizing a huge unlabeled dataset of various human actions. The resulting model operates at a high degree of abstraction, can anticipate arbitrarily far into the future, and decides how far to predict based on context.

Continue reading “Google AI Proposes Multi-Modal Cycle Consistency (MMCC) Method Making Better Future Predictions” | >

The new feature is part of Google’s Business Messages, a conversational messaging service that allows organizations to connect with people via Google Search, Google Maps, or their own business channels. For instance, Albertsons used Business Messages to share information with customers about vaccine administration. Suppose someone searched on Google for Safeway (an Albertson’s company). In that case, they could use the “message” button on Google Search to receive information like vaccine availability and how to book an appointment.

The new Bot-in-a-Box feature lets businesses launch a chatbot with an existing customer FAQ document, whether it’s from a web page or an internal document, to keep the service simple. The feature uses Google’s Dialogflow technology to create chatbots that can automatically understand and respond to customer questions without writing any code.

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Apple delivered an early holiday gift to the eco-conscious and the do-it-yourselfers: It said it would soon begin selling the parts, tools and instructions for people to do their own iPhone repairs. It was a major victory for the “right to repair” movement.

Apple said it would soon provide parts, tools and manuals to those who wanted to fix their own iPhones and Mac computers.

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In the wee morning hours of Tuesday (Nov. 16), the seven-person crew of the International Space Station (ISS) awoke in alarm. A Russian missile test had just blasted a decommissioned Kosmos spy satellite into more than 1,500 pieces of space debris — some of which were close enough to the ISS to warrant emergency collision preparations.

The four Americans, one German and two Russian cosmonauts aboard the station were told to shelter in the transport capsules that brought them to the ISS, while the station passed by the debris cloud several times over the following hours, according to NASA.

Ultimately, Tuesday ended without any reported damage or injury aboard the ISS, but the crew’s precautions — and the NASA administrator’s stern response to Russia — were far from an overreaction. Space debris like the kind created in the Kosmos break-up can travel at more than 17,500 mph (28,000 km/h), NASA says — and even a scrap of metal the size of a pea can become a potentially deadly missile in low-Earth orbit. (For comparison, a typical bullet discharged from an AR-15 rifle travels at just over 2,200 mph, or 3,500 km/h).

A Russian missile test blasted a Kosmos spy satellite into more than 1,500 pieces of space debris.

Continue reading “Russia’s missile test could have easily obliterated the International Space Station” | >