Lifeboat Foundation

Studies of brain network connectivity improved understanding on brain changes and adaptation in response to different pathologies. Synaptic plasticity, the ability of neurons to modify their connections, is involved in brain network remodeling following different types of brain damage (e.g., vascular, neurodegenerative, inflammatory). Although synaptic plasticity mechanisms have been extensively elucidated, how neural plasticity can shape network organization is far from being completely understood. Similarities existing between synaptic plasticity and principles governing brain network organization could be helpful to define brain network properties and reorganization profiles after damage. In this review, we discuss how different forms of synaptic plasticity, including homeostatic and anti-homeostatic mechanisms, could be directly involved in generating specific brain network characteristics. We propose that long-term potentiation could represent the neurophysiological basis for the formation of highly connected nodes (hubs). Conversely, homeostatic plasticity may contribute to stabilize network activity preventing poor and excessive connectivity in the peripheral nodes. In addition, synaptic plasticity dysfunction may drive brain network disruption in neuropsychiatric conditions such as Alzheimer’s disease and schizophrenia. Optimal network architecture, characterized by efficient information processing and resilience, and reorganization after damage strictly depend on the balance between these forms of plasticity.

Keywords: brain networks, connectivity, synaptic plasticity, Alzheimer’s disease (AD), schizophrenia, long-term potentiation (LTP), synaptic scaling, resting state functional MRI (rs-fMRI)

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Our H+ friend Rob Wilkes alerted me to this today!

March 20 (Reuters) — Elon Musk’s brain-chip startup Neuralink livestreamed on Wednesday its first patient implanted with a chip using his mind to play online chess.

Noland Arbaugh, the 29-year-old patient who was paralyzed below the shoulder after a diving accident, played chess on his laptop and moved the cursor using the Neuralink device. The implant seeks to enable people to control a computer cursor or keyboard using only their thoughts.

Continue reading “Musk’s Neuralink shows first brain-chip patient playing online chess” »

Research in mice shows limited intakes of one particular essential amino acid can slow the impacts of aging and even lengthen their lifespan.

Scientists are now wondering if these findings could help people improve their longevity and quality of life.

Isoleucine is one of three branched-chain amino acids we use to build proteins in our bodies. It is essential for our survival, but since our cells can’t produce it from scratch, we have to get it from sources like eggs, dairy, soy protein and meats.

Where are the best places to find longevity research? We just updated this list of top anti-aging research journals; any we missed?

Finding quality life-extension research is tough, so we’ve compiled the best anti-aging research journals and resources, all in one place!

OpenAI CEO Sam Altman is remaining tight-lipped about the company’s secretive Q* project — even after admitting that his company is something of a leaky ship.

Even among those who followed along with OpenAI’s November massacre that saw Altman temporarily ousted, it’s easy to overlook the Q* (pronounced “queue-star”) of it all, particularly because nobody outside the company really knows what the heck it is.

Continue reading “Sam Altman Shuts Down Q* Questions” »

On Monday, Nvidia unveiled the Blackwell B200 tensor core chip—the company’s most powerful single-chip GPU, with 208 billion transistors—which Nvidia claims can reduce AI inference operating…

Jensen Huang believes coding languages are a thing of the past.

Neuralink, Elon Musk ’s brain chip startup, released a video on Wednesday showing the company’s first patient using a laptop with just his mind.

The video, which was livestreamed on Neuralink’s account on X, showed 29-year-old Noland Arbaugh playing a game of chess on his laptop using Neuralink’s brain computer interface (BCI) technology. Arbaugh is paralyzed from the shoulders down due to what he describes as a “freak diving accident.”

“It’s all brain power there,” Arbaugh said, referring to his ability to use a mouse and keyboard unassisted. He later added, “Basically, it was like using the Force on the cursor and I could get it to move wherever I wanted.”

Scientists from Massey University in New Zealand, the University of Mainz in Germany, Sorbonne University in France, and the Facility for Rare Isotope Beams (FRIB) discuss the limit of the periodic table and revising the concept of the “island of stability” with recent advances in superheavy element research. Their work first appeared in Nature Reviews Physics.

In addition to the Nature Reviews Physics, Physics Reports has published a review on the atomic electronic structure theory for superheavy elements.

What is the heaviest bound nucleus and the heaviest bound atom and what are their properties? The nuclei of chemical elements with more than 103 protons are labeled as “superheavy.” They are part of a vast unknown territory of these nuclei that scientists are trying to uncover. Exploring this uncharted territory provides prospects for discoveries that connect the broad areas of science.