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Small molecules restore mutant mitochondrial DNA polymerase activity

Mitochondrial diseases caused by POLG mutations vary in severity. In young children, these diseases can quickly result in brain damage and life-threatening liver problems while others suffer muscle weakness, epilepsy, and organ failure later in childhood. POLG mutations recently received media attention when Prince Frederik of Nassau in Luxembourg died in March 2025 at just 22 years of age.

Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning

Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasticity in vivo during learning and whether these rules…

Scientists discover pioneering technique to accelerate accurate quantum measurements

Researchers have developed a new way to speed up quantum measurements, a vital building block for the next generation of quantum technologies.

Accurate and fast will be crucial for , but are fragile and susceptible to disturbance which can cause errors. Previous work in this area presented a fundamental challenge—scientists were only able to increase the accuracy of measurements in quantum systems by sacrificing speed.

A team of quantum experts, led by the University of Bristol, have struck upon a novel way to overcome this problem, published in a Physical Review Letters journal paper.

“France Can’t Do It Alone”: U.S. Delivers 60-Foot Superconducting Magnet Beast Crucial to the $22 Billion ITER Nuclear Fusion Dream

IN A NUTSHELL 🔧 The United States has delivered a colossal superconducting magnet to France’s ITER project, advancing nuclear fusion technology. 🤝 Collaboration among eight American companies was essential to construct the solenoid’s support structure for the reactor. 🔄 Four out of six solenoid modules have been installed, with completion expected by the year’s end.

Scientists Discover New “Hall Effect” That Could Revolutionize Electronics

Scientists discovered a new Hall effect driven by spin currents in noncollinear antiferromagnets, offering a path to more efficient and resilient spintronic devices.

A research team led by Colorado State University graduate student Luke Wernert and Associate Professor Hua Chen has identified a previously unknown type of Hall effect that could lead to more energy-efficient electronic devices.

Their study, published in Physical Review Letters.

[Literature Review] Two Heads are Better Than One: Test-time Scaling of Multi-agent Collaborative Reasoning

This paper introduces an adaptive multi-agent framework to enhance collaborative reasoning in large language models (LLMs). The authors address the challenge of effectively scaling collaboration and reasoning in multi-agent systems (MAS), which is an open question despite recent advances in test-time scaling (TTS) for single-agent performance.

The core methodology revolves around three key contributions:

1. **Dataset Construction:** The authors create a high-quality dataset, M500, comprising 500 multi-agent collaborative reasoning traces. This dataset is generated automatically using an open-source MAS framework (AgentVerse) and a strong reasoning model (DeepSeek-R1). To ensure quality, questions are selected based on difficulty, diversity, and interdisciplinarity. The generation process involves multiple agents with different roles collaborating to solve challenging problems. Data filtering steps are applied to ensure consensus among agents, adherence to specified formats (e.g., using tags like “ and ‘boxed{}‘), and correctness of the final answer. The filtering criteria are based on Consensus Reached, Format Compliance, and Correctness. The data generation is described in Algorithm 1 in the Appendix.