Cancer treatment with a cell-based immunotherapy causes mild cognitive impairment, a Stanford Medicine team found. They also identified compounds that could treat it.
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Comparative analysis of human and mouse ovaries across age
The mouse is a tractable model for human ovarian biology; however, its utility is limited by incomplete understanding of how transcription and signaling differ interspecifically and with age. We compared ovaries between species using three-dimensional imaging, single-cell transcriptomics, and functional studies. In mice, we mapped declining follicle numbers and oocyte competence during aging; in human ovaries, we identified cortical follicle pockets and decreases in density. Oocytes had species-specific gene expression patterns during growth that converged toward maturity. Age-related transcriptional changes were greater in oocytes than in granulosa cells across species, although mature oocytes change more in humans. We identified ovarian sympathetic nerves and glia; axon density increased in aged ovaries and, when ablated in mice, perturbed folliculogenesis.
Earliest Light in the Universe Reveals New Surprises (CMB Updates)
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Why we can’t stop clicking on rage bait
Stanford research reveals creators feel exhausted, depressed, and financially unstable due to constant pressure to post, algorithm unpredictability, and frequent “demonetization.” While rage bait may work short-term, it’s unsustainable. Creators eventually seek other revenue streams, only to be replaced by new outrage merchants.
Bottom line: Rage bait is a symptom of platforms’ engagement-based economic incentives—not an isolated phenomenon, but a “highly visible result” of the ecosystem social media companies have created.
“Rage bait” is Oxford’s Word of the Year. What makes anger so appealing?
BREAKING: Grok Just Changed Tesla Cars Forever
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Hoarseness With Supraglottic Ulcer in an Immunocompetent Adult
In a patient from a histoplasmosis-endemic region, laryngeal histoplasmosis caused by Histoplasma capsulatum was diagnosed after biopsy revealed granulomatous inflammation and fungal organisms.
Early consideration and biopsy are key when evaluating ulcerative laryngeal lesions.
A 61-year-old man presented to the otolaryngology clinic with a 2-month history of progressive hoarseness, dysphagia, odynophagia, and persistent globus sensation. What is your diagnosis?