It’s that time of year where the federal holiday in the United States commemorating the Declaration of Independence of the United States, (on July 4, 1776) is celebrated. To all my American fans I hope you have an awesome day! To celebrate I’m listing my favorite superheroes to rock the “Red, White and Blue”.
Happy Independence Day (Fourth of July)!
The adhesion and colonization or biofilm formation include primary stage in bacterial infections. Major adhesion virulence factors in this step include type I fimbriae (FimH) and pilli structures for attachment to the host cells7,8. Furthermore, numerous bacteria secrete toxins and extracellular enzymes which play a crucial role in the apoptosis or necrosis of epithelial cells or immunocytes. Various virulence factors of A. baumannii such as adhesins genes like kpsMII (group 2 capsule synthesis) and fimH, tratT (serum resistance associated), fyuA (yersiniabactin receptor) and iutA (aerobactin receptor) have been investigated previously9,10. An important polysaccharide for biofilm formation is encoded by pgaABCD locus11. Biofilm production is a strategy to escape from harsh conditions and immune responses, hence play as reservoirs for drug-resistant systemic infections. Biofilm-producing A. baumannii has been isolated from several infectious origins such as pneumonia and devise-associated infections. Bacterial within biofilm can resist significantly more against antibiotics compared to planktonic mode of growth12. Hence, biofilm-mediated infections are in relapse more frequently13.
Therefore, there is an urgent need to enhance the effects of antimicrobials against pathogenic bacteria. In recent years, interest has enhanced towards application of nanoparticles as therapeutic regimens14,15,16,17,18,19,20,21. Silver nanoparticles (AgNPs), which have low toxicity in ecosystems and have high rate of surface capacity, can inhibit accumulation of biofilm materials responsible for evasion and protection22,23,24.
The aim of this study was to isolate A. baumannii from wound infections, determine their resistance and virulence profile, and assess the impact of AgNPs on the bacterial growth, virulence and biofilm-related gene expressions in the isolated strains.
A new topic a new challenge for future civilizations.
I won’t write an introduction I will ask couple of questions to make you think about it.
Continue reading “Spermageddon: are humans going extinct?” »
Android malware known as FluBot is continuing to cause mayhem across some European countries, and there is speculation that the threat actors behind it may decide to target other geographies, including the United States. Here’s why you should be vigilant, how FluBot operates, and how you can remove this Android nasty from your device.
It’s also worth noting that this advice will help you stay safe from other Android malware strains. In recent days, cybercriminals have begun to target Europeans with TeaBot (also known as Anatsa or Toddler), an Android malware family that uses exactly the same technique as FluBot to spread and to lure users into giving up their sensitive data. FluBot and TeaBot are detected by ESET products as variants of the Android/TrojanDropper. Agent family.
I could probably be described as a SpaceX enthusiast. I catch their launches when I can, and I’ve watched the development of Starship with great interest. But the side-effect of SpaceX’s reusable launch system is that getting to space has become a lot cheaper. Having excess launch capacity means that space projects that were previously infeasible become suddenly at least plausible. One of those is Starlink.
Starlink is SpaceX’s satellite Internet service. Wireless and cellular internet have helped in some places, but if you really live out in the sticks, satellite internet is your only option. And while satellite Internet isn’t exactly new, Starlink is a bit different. Hughesnet, another provider, has a handful of satellites in geostationary orbit, which is about 22000 miles above the earth. To quote Grace Hopper, holding a nearly foot-long length of wire representing a nanosecond, “Between here and the satellite, there are a very large number nanoseconds.”
How do simple creatures manage to move to a specific place? Artificial intelligence and a physical model from TU Wien can now explain this.
How is it possible to move in the desired direction without a brain or nervous system? Single-celled organisms apparently manage this feat without any problems: for example, they can swim towards food with the help of small flagellar tails.
How these extremely simply built creatures manage to do this was not entirely clear until now. However, a research team at TU Wien (Vienna) has now been able to simulate this process on the computer: They calculated the physical interaction between a very simple model organism and its environment. This environment is a liquid with a non-uniform chemical composition, it contains food sources that are unevenly distributed.
A research team from TU Wien together with US research institutes came across a surprising form of ‘quantum criticality’; this could lead to a design concept for new materials.
In everyday life, phase transitions usually have to do with temperature changes — for example, when an ice cube gets warmer and melts. But there are also different kinds of phase transitions, depending on other parameters such as magnetic field. In order to understand the quantum properties of materials, phase transitions are particularly interesting when they occur directly at the absolute zero point of temperature. These transitions are called “quantum phase transitions” or a “quantum critical points.”
Such a quantum critical point has now been discovered by an Austrian-American research team in a novel material, and in an unusually pristine form. The properties of this material are now being further investigated. It is suspected that the material could be a so-called Weyl-Kondo semimetal, which is considered to have great potential for quantum technology due to special quantum states (so-called topological states). If this proves to be true, a key for the targeted development of topological quantum materials would have been found. The results were found in a cooperation between TU Wien, Johns Hopkins University, the National Institute of Standards and Technology (NIST) and Rice University and has now been published in the journal Science Advances.
Sixteen lawyers competed against an Alibaba AI program that found more risks in legal contracts than the lawyers who were not assisted by the program.
Drug Delivery.
Covid-19
Without these lipid shells, there would be no mRNA vaccines for COVID-19.
Continue reading “Without these lipid shells, there would be no mRNA vaccines for COVID-19” »
