Lifeboat Foundation

How slight differences could have forever changed our cosmic history.

The Lunar Lantern, an intriguing concept for establishing a human presence on the Moon, is currently being featured at the 17th International Architecture Exhibition.

In October of 2024, NASA’s Artemis Program will return astronauts to the surface of the Moon for the first time since the Apollo Era. In the years and decades that follow, multiple space agencies and commercial partners plan to build the infrastructure that will allow for a long-term human presence on the Moon. An important part of these efforts involves building habitats that can ensure the astronauts’ health, safety, and comfort in the extreme lunar environment.

This challenge has inspired architects and designers from all over the world to create innovative and novel ideas for lunar living. One of these is the Lunar Lantern, a base concept developed by ICON (an advanced construction company based in Austin, Texas) as part of a NASA-supported project to build a sustainable outpost on the Moon. This proposal is currently being showcased as part of the 17th International Architecture Exhibition at the La Biennale di Venezia museum in Venice, Italy.

Continue reading “The Lunar Lantern Could be a Beacon for Humanity on the Moon” »

After the launch of Tiangong space station’s core module in April, China took on its next challenge: send astronauts to live there.

The crew of Shenzhou-12 successfully docked at Tiangong this week, and will stay on board for 3 months.

Fossilized bones from extinct taxa harbor the potential for obtaining protein or DNA sequences that could reveal evolutionary links to extant species. We used mass spectrometry to obtain protein sequences from bones of a 160000-to 600000-year-old extinct mastodon (Mammut americanum) and a 68-million-year-old dinosaur (Tyrannosaurus rex). The presence of T. rex sequences indicates that their peptide bonds were remarkably stable. Mass spectrometry can thus be used to determine unique sequences from ancient organisms from peptide fragmentation patterns, a valuable tool to study the evolution and adaptation of ancient taxa from which genomic sequences are unlikely to be obtained.

The metazoan mitochondrial genome (mitogenome) is an ideal model system for comparative and evolutionary genomic research. The typical mitogenome of metazoans encodes a conserved set of 37 genes for 13 protein-coding genes (PCGs), two ribosomal RNA (rRNA) genes, and 22 transfer RNA (tRNA) genes¹, with genome-level characters, such as genome size, gene content, and gene order, display high diversity in some lineages^2,3. Gene rearrangements are observed frequently in some groups, while gene duplication and loss are distributed sporadically in limited lineages such as Bivalvia, Cephalopod, and Afrobatrachia^4,5,6. These remaining duplicate genes and pseudogenes represent important data for exploring the evolutionary history and mechanisms of gene rearrangement and recruitment. For the arrangement of mitochondrial genes, the variation in relative positions of PCGs and rRNA genes are more limited compared with that of tRNA genes across organisms within a phylum⁷. The tRNA genes with characteristics of diverse changes in relative position, gene content, and secondary structure, are considered as an important tool in studying the evolution of mitogenome, in particular to the rearrangement mechanism^8,9,10. Additionally, its variation is usually linked to evolutionary relationships in a wide range of lineages at different taxonomic levels suggesting these features of tRNA could be utilized as useful phylogenetic markers¹¹.

The extensive gene rearrangements (including PCGs and RNA) of insect mitogenomes have been detected in several lineages within the Diptera (Trichoceridae, Cecidomyiidae), Hemiptera (Enicocephalidae), Hymenoptera, Thysanoptera, Psocoptera and Phthiraptera^{12,13,14,15,16,17,18}, while most of investigated mitogenomes share the same gene order with the hypothesized ancestral pancrustacean mitogenome arrangement¹⁹ or possess rare tRNA rearrangement. Previously reported dictyopteran mitogenomes consistently display the typical ancestral gene order and content, however only two species are praying mantises and the rest are cockroaches and termites. Members of the Mantodea, a separate lineage within the Dictyoptera, have evolved many unique morphological and behavioural features as the ambush and pursuit predators^20,21,22. A better understanding of the diversity of mitogenome evolution in this enigmatic order underlines the need for exploring more taxa with the diverse praying mantis.

Herein, we report eight new mitogenomes from Mantodea and describe their general characteristics. Two new gene rearrangements and reassignment of tRNA genes are described, and evolutionary mechanisms for the gene rearrangements and duplication are discussed. Further, we examine the relationship between tRNA gene duplication and codon usage, and investigate whether these tRNA features vary with phylogeny.

A new study led by University of Maryland and UCLA researchers found that DNA from tissue samples can be used to accurately predict the age of bats in the wild. The study also showed age-related changes to the DNA of long-lived species are different from those in short-lived species, especially in regions of the genome near genes associated with cancer and immunity. This work provides new insight into causes of age-related declines.

This is the first research paper to show that animals in the wild can be accurately aged using an epigenetic clock, which predicts age based on specific changes to DNA. This work provides a new tool for biologists studying animals in the wild. In addition, the results provide insight into possible mechanisms behind the exceptional longevity of many bat species. The study appears in the March 12, 2021, issue of the journal Nature Communications.

“We hoped that these epigenetic changes would be predictive of age,” said Gerald Wilkinson, a professor of biology at UMD and co-lead author of the paper. “But now we have the data to show that instead of having to follow animals over their lifetime to be sure of their age, you can just go out and take a tiny sample of an individual in the wild and be able to know its age, which allows us to ask all kinds of questions we couldn’t before.”

:Ibotenic Acid Biosynthesis in the Fly Agaric Is Initiated by Glutamate Hydroxylation.

The fly agaric, Amanita muscaria, is widely known for its content of the psychoactive metabolites ibotenic acid and muscimol. However, their biosynthetic pathway and the respective enzymes are entirely unknown. 50 years ago, the biosynthesis was hypothesized to start with 3‐hydroxyglutamate. Here, we build on this hypothesis by the identification and recombinant production of a glutamate hydroxylase from A. muscaria. The hydroxylase gene is surrounded by six further biosynthetic genes, which we link to the production of ibotenic acid and muscimol using recent genomic and transcriptomic data. Our results pinpoint the genetic basis for ibotenic acid formation and thus provide new insights into a decades‐old question concerning a centuries‐old drug.

Keywords: biosynthesis, enzyme catalysis, fly agaric, hydroxylation, ibotenic acid.

The nation may launch its first crewed spaceflight in 2023.

So far, only the U.S., the Soviet Union/Russia and China have launched humans to Earth orbit. But India aims to join that exclusive club in the next year or two.

On Jan. 15, a hacker tried to poison a water treatment plant that served parts of the San Francisco Bay Area. It didn’t seem hard.

The hacker had the username and password for a former employee’s TeamViewer account, a popular program that lets users remotely control their computers, according to a private report compiled by the Northern California Regional Intelligence Center in February and seen by NBC News.

After logging in, the hacker, whose name and motive are unknown and who hasn’t been identified by law enforcement, deleted programs that the water plant used to treat drinking water.