Lifeboat Foundation

Stem-cell-based therapies can potentially reverse organ dysfunction and diseases, but the removal of impaired tissue and activation of a program leading to organ regeneration pose major challenges. In mice, a 4-day fasting mimicking diet (FMD) induces a stepwise expression of Sox17 and Pdx-1, followed by Ngn3-driven generation of insulin-producing β cells, resembling that observed during pancreatic development. FMD cycles restore insulin secretion and glucose homeostasis in both type 2 and type 1 diabetes mouse models. In human type 1 diabetes pancreatic islets, fasting conditions reduce PKA and mTOR activity and induce Sox2 and Ngn3 expression and insulin production. The effects of the FMD are reversed by IGF-1 treatment and recapitulated by PKA and mTOR inhibition. These results indicate that a FMD promotes the reprogramming of pancreatic cells to restore insulin generation in islets from T1D patients and reverse both T1D and T2D phenotypes in mouse models.

A periodic short-term diet that mimics fasting modulates β-cell regeneration and promotes insulin secretion and glucose homeostasis with potential to treat both type 1 and type 2 diabetes.

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A man with terminal heart disease is responding well three days after being given a genetically modified pig heart in a first-of-its-kind surgery, his doctors reported on Monday.
The surgery, performed by a team at the University of Maryland Medicine in the United States, is among the first to demonstrate the feasibility of a pig-to-human heart transplant, a field made possible by new gene editing tools.
If proven successful, scientists hope pig organs could help alleviate shortages of donor organs.
For David Bennett, a 57-year-old from Maryland, the heart transplant was his last option.

Al Jazeera’s Barbara Angopa reports.

Continue reading “US man recovering after ‘breakthrough’ pig heart transplant” »

A new stem cell-based bioimplant could help the millions of people who suffer from osteoarthritis avoid surgeries.

The car market is changing, and quickly.
it seems combustion engines are declining quickly in popularity, as electric vehicles, led by @Tesla 0, are taking the market by storm, selling as fast as they can be produced, and outselling all but the very cheapest city cars in most markets.

But are they for you?
Do they have the range and can you afford to make the switch?

Continue reading “Electric vs Petrol Car. Which One For You?” »

Researchers at the Indian Institute of Technology Bhubaneswar, in collaboration with TCS Research and Wageningen University, recently devised a new strategy that could improve coordination among different robots tackling complex missions as a team. This strategy, introduced in a paper pre-published on arXiv, is based on a split-architecture that addresses communication and computations separately, while periodically coordinating the two to achieve optimal results.

The researchers’ paper was recently presented at the IEEE RoboCom 2022 conference, held in conjunction with IEEE CCNC 2022, a top tier conference in the field of networking and distributed computing. At IEEE RoboCom 2022, it received the Best Paper Award.

“Swarm-robotics is on the path to becoming a key tool for human civilization,” Dr. Sudipta Saha, the lead researcher of the team that carried out the study, told TechXplore. “For instance, in medical science, it will be necessary to use numerous nano-bots to boost immune-therapy, targeted and effective drug transfer, etc.; while in the army it will be necessary for exploring unknown terrains that are hard for humans to enter, enabling agile supervision of borders and similar activities. In construction, it can enable technologies such as large-scale 3D printing and in agriculture it can help to monitor crop health and intervene to improve yields.”

Does the advent of machine learning mean the classic methodology of hypothesise, predict and test has had its day?

Suspended beneath a thick canopy of trees, the sloth inches along with slow strides. Painfully slow. Intentionally slow. Crawling high up among the branches, traipsing along a 100-foot steel cable, the little creature is like a lethargic acrobat. But its goal is not to delight or to put on a show; in fact, just the opposite. This sloth is all about stealth, observation, and collecting as much sunlight as possible.

After all, this is a solar-powered robot.

What are the weird radio waves detected in deep space known as ASKAP J173608.2–321635, and how can astronomers hope to solve the mystery?