Lifeboat Foundation

Molnupiravir, a wide-spectrum antiviral that is currently in phase 2/3 clinical trials for the treatment of COVID-19, is proposed to inhibit viral replication by a mechanism known as ‘lethal mutagenesis’. Two recently published studies reveal the biochemical and structural bases of how molnupiravir disrupts the fidelity of SARS-CoV-2 genome replication and prevents viral propagation by fostering error accumulation in a process referred to as ‘error catastrophe’.

[Matt] from [DIY Perks] has made a name for himself building nice custom computing machines, and his latest triple-monitor luggable PC (video after the break) is sure to give most high-performance desktop machines a run for their money.

The large central monitor folding laptop monitors mounted vertically on either size look impressive, but only just scratches the surface of this build. Hidden behind aluminum panels are Ryzen 5950X CPU and RTX 3,080 GPU with water cooling, 64 GB of RAM, and two 8 TB SSDs. A set of high-quality speaker drivers, subwoofer, and audio amps is also included. All this hardware pulls about 600 W of power from a large DC-DC converter block, which in turn receives power from either a pair of onboard AC-DC converters or a 16 V – 63 V DC source, like a battery system.

Continue reading “Triple Monitor Luggable PC Is An All In One Powerhouse” »

MASK Architects has designed the world’s first steel 3D printed structure of modular houses for Nivola Museum’s visitors, Tourists and Artists in Orani, city of Sardinia. Öznur Pınar Cer and Danilo Petta have Inspired from the work of “Costantino Nivola”, they have designed “Exosteel Mother Nature” modular houses which they have taken inspiration from him sculpture called the “La Madre”.

The studio is the first architecture and design studio in the world to use a steel 3D-printed “exoskeleton” construction system that supports and distributes all the functional elements of the building, using their new solution of construction technique which they called “EXOSTEEL”.

The house is composed firstly by a hollow central column inserted for one / third of its length into the ground and by various organic branches that support the three floors of the building. On each floor a perimeter frame divides and supports the facades made up of panels modeled to follow the organic shape of the house.

Pfizer Inc (PFE.N) said on Thursday it was recalling all lots of its anti-smoking treatment, Chantix, due to high levels of cancer-causing agents called nitrosamines in the pills.

The drugmaker paused distribution of the drug in June, and has already recalled a number of lots of the medicine so far. [USN: L4N2PK3WK]

Pfizer asked wholesalers and distributors on Thursday to stop the use and distribution of the tablets immediately.

Continue reading “Pfizer recalls all lots of anti-smoking drug over carcinogen presence” »

Only two new coronaviruses have spread globally the past 2 decades: SARS-CoV, which caused an outbreak of severe acute respiratory syndrome (SARS) in 2,003 and SARS-CoV-2, the virus that causes COVID-19. But that may just be the tip of the iceberg of undetected infections with related viruses emerging from bats, a new paper claims. In a preprint published yesterday researchers estimate that an average of 400,000 people are likely infected with SARS-related coronaviruses every year, in spillovers that never grow into detectable outbreaks.

The researchers, including Peter Daszak from the EcoHealth Alliance and Linfa Wang from Duke-NUS Medical School in Singapore, created a detailed map of the habitats of 23 bat species known to harbor SARS-related coronaviruses, the group to which SARS-CoV and SARS-CoV-2 belong, and then overlaid it with data on where humans live to create a map of potential infection hot spots. They found that close to 500 million people live in areas where spillovers can occur, including northern India, Nepal, Myanmar, and most of Southeast Asia. The risk is highest in southern China, Vietnam, Cambodia, and on Java and other islands in Indonesia (see map, below).

Study pinpoints Asian regions that could spark the next coronavirus pandemic.

Continue reading “SARS-like viruses may jump from animals to people hundreds of thousands of times a year” »

A new Rutgers study will examine how COVID-19 is affecting individuals in a number of cognitive-related areas, including memory loss, “brain fog,” and dementia.

“Many people who recover from mild or moderate COVID-19 notice slowed thinking or memory loss, and this motivated us to leverage our experience in studying cognitive issues related to Alzheimer’s disease, multiple sclerosis, and HIV to examine this phenomenon,” said Dr. William T. Hu, associate professor and chief of cognitive neurology at Rutgers Robert Wood Johnson Medical School and the Institute for Health, Health Care Policy, and Aging Research.

A leading cognitive neurologist and neuroscientist, Dr. Hu is spearheading the characterization of cognitive impairment following mild-to-moderate COVID-19 at Rutgers.

In semiconductor device applications, there is an increasing demand for semiconductors with very high carrier concentrations. The semiconductor material parameters, namely carrier density and mobility, primarily determine device performance. Hence, it is important to accurately characterize the carrier density and mobility of a semiconductor for the development of its device applications.

The use of THz waves, or electromagnetic radiation with wavelengths of around 300 µm and frequency of about 1 THz, in the nondestructive testing of semiconductors has been continuously expanding. Free carriers in a material absorb THz radiation, which makes it possible to estimate the electrical properties of semiconductors using THz waves.

Researchers at Osaka University, in collaboration with Nippo Precision Co., Ltd., developed a THz time-domain ellipsometry system (Tera Evaluator) that extends the range of carrier concentrations measurable by THz waves up to ~10²⁰ cm^-3 and potentially higher by improving the precision of said optical technique. In THz time-domain ellipsometry, linearly polarized THz pulses are incident on a sample and the electric field strength of the reflected THz waves as a function of time is measured. Specifically, the reflected waves polarized in the direction parallel ℗ and perpendicular (s) to the plane of incidence are of interest. The ratio of the p-and s-polarization components yields information on the electric permittivity of the sample, allowing for the evaluation of the carrier density and mobility. As such, unlike THz time-domain spectroscopy, THz time-domain ellipsometry does not require reference measurements through an aperture or standard mirror.

According to researchers from the Singapore University of Technology and Design (SUTD), a recently discovered family of two-dimensional (2D) semiconductors could pave the way for high-performance and energy-efficient electronics. Their findings, published in npj 2D Materials and Applications, may lead to the fabrication of semiconductor devices applicable in mainstream electronics and optoelectronics—and even potentially replace silicon-based device technology altogether.

In the quest of miniaturizing electronic devices, one well-known trend is Moore’s law, which describes how the number of components in the integrated circuits of computers doubles every two years. This trend is possible thanks to the ever-decreasing size of transistors, some of which are so small that millions of them can be crammed onto a chip the size of a fingernail. But as this trend continues, engineers are starting to grapple with the inherent material limitations of silicon-based device technology.

“Due to the quantum tunneling effect, shrinking a silicon-based transistor too small will lead to highly uncontrollable device behaviors,” said SUTD Assistant Professor Ang Yee Sin, who led the study. “People are now looking for new materials beyond the ‘silicon era’, and 2D semiconductors are a promising candidate.”

Is this US ready for this Eric Klien?

Israeli defense technology continues to improve.

Continue reading “What Are Robot Soldiers Doing on the Gaza Border Wall?” »