Lifeboat Foundation

A team of physicists, including the University of Warwick, have proved that a subatomic particle can switch into its antiparticle alter-ego and back again, in a new discovery just revealed last week.

“This new result shows for the first time that charm mesons can oscillate between the two states.”

An extraordinarily precise measurement made by UK researchers using the LHCb experiment at CERN has provided the first evidence that charm mesons can change into their antiparticle and back again.

Using CRISPR-Cas9, the researchers subsequently removed the one copy of the Ndn gene from the 15q dup mouse model to generate mice with a normalized genomic copy number for this gene (15q dupΔNdn mouse). Using this model, they demonstrated that the abnormalities observed in 15q dup mice (abnormal spine turnover rate and decreased inhibitory synaptic input) could be ameliorated.

A research group including Kobe University’s Professor TAKUMI Toru (also a Senior Visiting Scientist at RIKEN Center for Biosystems Dynamics Research) and Assistant Professor TAMADA Kota, both of the Physiology Division in the Graduate School of Medicine, has revealed a causal gene (Necdin, NDN) in autism model mice that have the chromosomal abnormality called copy number variation.

The researchers hope to illuminate the NDN gene’s molecular mechanism in order to contribute towards the creation of new treatment strategies for developmental disorders including autism.

Continue reading “Researchers discover new genetic driver of autism and other developmental disorders” »

As someone with a passionate interest in longevity, transhumanism and biological immortality — I am naturally both excited and optimistic that medical technology will continue to advance in my lifetime — hopefully to the point where humanity has cured or at least greatly mitigated the signs & symptoms of most diseases as well as disabilities, radically expanded human biological lifespan regardless of age, and created a more dignified existence for all as a result of rapid breakthroughs in robotics, AI, automation, nanotechnology, 3D printing and biotechnology — which I hope in turn will largely eradicate poverty, disease, food & shelter insecurity, natural resource scarcity, environmental degradation and income inequality. I know that some of my likeminded friends are far more skeptical that we will ever see outright cures or significant mitigations for major diseases and disabilities — much less radical life extension or perhaps biological immortality in human beings — which are widely available on a commercial basis. They cite their belief that pharmaceutical giants, a plethora of not for profit organizations (i.e., American Cancer Society), and many other allegedly “self-interested parties” supposedly allied with government regulatory bodies — apparently do not want to see diseases or disabilities cured or lifespan significantly extended — EVER — as this would prevent them from earning untold sums selling treatments and supports for such things on a regular ongoing basis (i.e., chemo drugs for cancer, statins for cardiovascular disease, inhaled/oral steroids for lung disease, renal replacement therapy for kidney disease, mobile supports for spinal cord injuries, ect.) They believe that too much money would be at stake, too many jobs on the line and the entire “pharma-medical-academic industrial complex” supposedly at great risk, if actual cures or significant mitigations ever saw the light of day. Some of these friends even cite their belief that fully autonomous, accident proof, self-driving cars will most likely never occur — as it would supposed put the entire auto insurance industry at existential risk as well as deprive law enforcement agencies of a key source of reliable revenue (issuing speeding tickets) This one makes me giggle! 🤭 My friends also believe that radical life extension in human beings — much less biological immortality — would apparently upset the proverbial apple cart — where the “powers that be” are concerned — in terms of everything from the highly lucrative profits which are derived from pharmaceutical sales, old age homes, life and health insurance plans, personal financial services and all of the sales of key products and services associated with the aging process — to macroeconomic considerations such as the long term viability of government entitlement programmes. They believe that government regulatory authorities allegedly working at the behest of the aforementioned self-interested parties will always seek to delay, disrupt or even derail ANY and ALL significant progress into cures/mitigations for disease/disabilities, radical human life extension and/or human biological immortality. Apparently, new biotech start ups which do advance the aforementioned things are allegedly “always aggressively bought out by monopoly capital — with their cures and advances indefinitely suppressed” I personally tend to be more on the positive and optimistic side where these things are concerned — but perhaps these rather pessimistic arguments do have some validity — minus the implied conspiracy theory aspect. Do you think human beings will ever be “allowed” to truly be free from illnesses and disabilities? Will we ever be “permitted” to radically expand our lifespans or even become biologically immortal at some point? Please discuss.

I have already taken a few courses for a master’s in physics at the University of Antwerp and I want to complete it there. In a bachelor’s degree you get a basis of knowledge in physics and quantum physics, but it gets more detailed in a master’s.

The main reason I chose to study physics is because my end goal is to achieve immortality. One of the areas that is important in the study of immortality is physics, but as of yet, there is no mapped out path to achieve it.

Continue reading “I’m 11, I have a physics degree and want to make humans immortal” »

The overall response rate in the trial population was 40% (95% CI 29%-51%). Median duration of response was 11.1 months (95% CI 6.9-not evaluable), with nearly two-thirds of patients having a duration of response of at least 6 months.

The FDA approved amivantamab-vmjw (Rybrevant) on Friday as the first treatment for patients with non-small cell lung cancer (NSCLC) harboring EGFR exon 20 insertion mutations.

Amivantamab is a bispecific antibody that targets EGFR and mesenchymal-epithelial transition factor pathways. EGFR exon 20 insertion mutations occur in approximately 2% to 3% of NSCLC patients, and are associated with rapid cell growth.

Continue reading “FDA OKs Bispecific Antibody for Rare Lung Cancer Subtype” »

Tesla began sending out over-the-air software updates for its long-awaited “Full Self-Driving” beta version 9, the definitely-not-autonomous-but-certainly-advanced driver assist system.

As promised by Elon Musk, the software update (2021.4.18.12) began uploading after midnight on Friday, giving thousands of Tesla owners who have purchased the FSD option access to the feature, which enables drivers to use many of Autopilot’s advanced driver-assist features on local, non-highway streets.

Rapid Motor Adaptation-enabled test robot traverses various types of terrain. (Images courtesy Berkeley AI Research, Facebook AI Research and Carnegie Mellon University)

Not only could the robot adjust to novel circumstances, but it could also do so in fractions of a second rather than in minutes or more. This is critical for practical deployment in the real world.

Continue reading “New AI strategy enables robots to rapidly adapt to real world environments” »

Planets which are tilted on their axis, like Earth, are more capable of evolving complex life. This finding will help scientists refine the search for more advanced life on exoplanets. This NASA-funded research is presented at the Goldschmidt Geochemistry Conference.

Since the first discovery of exoplanets (planets orbiting distant stars) in 1992, scientists have been looking for worlds that might support life. It is believed that to sustain even basic life, exoplanets need to be at just the right distance from their stars to allow liquid water to exist; the so-called “Goldilocks zone.” However, for more advanced life, other factors are also important, particularly atmospheric oxygen.

Oxygen plays a critical role in respiration, the chemical process which drives the metabolisms of most complex living things. Some basic life forms produce oxygen in small quantities, but for more complex life forms, such as plants and animals, oxygen is critical. Early Earth had little oxygen even though basic life forms existed.

Detecting ‘technosignatures’ such as hypothetical Dyson spheres in space could lead us to extraterrestrial life, and now NASA is funding the search.

Ageing is an incredibly complicated process, so much so that we do not yet understand exactly how complicated it is. It is in fact so complicated, that it could actually be incredibly simple. Confused? Well, imagine if you were a structural engineer who was trying to understand why a building collapsed. From an initial inspection of the rubble, it may be extremely difficult to work out exactly what went wrong. Was the building made from inferior materials? Was it built incorrectly? Was its destruction deliberate? Did it just fall apart due to age? All of these are possible, but what was the true cause for its destruction? Well, that is the same mystery we are trying to solve in longevity research. We can see the damage that is caused by ageing, but what is the cause? Is it a general accumulation of damage, or are there single points of failure which have knock on effects that affect the entire body? A cascade failure if you will.

Of the many different changes that occur during the ageing process, one of the most well-known and understood is the decreased capacity for our body to produced chemical energy, which has a knock-on effect throughout the body. This results in a general decrease in our ability to carry out cellular functions and will therefore effective everything from muscle strength to DNA replication and repair. This decrease in energy output has been linked to defects in our mitochondria, but in addition to these physical defects that occur in these small organisms, we now know that they also suffer a decreased capacity to carry out their function due to lacking a critical coenzyme called Nicotinamide adenine dinucleotide (NAD). Anyone who has taken a high school level biology class will probably recognise this enzyme as part of the electron transport chain in respiration.