Lifeboat Foundation

Two drugs approved decades ago not only counteract brain damage caused by Alzheimer’s disease in animal models, the same therapeutic combination may also improve cognition.

Sounds like a slam dunk in terms of a cure—but not yet. Researchers currently are concentrating on animal studies amid implications that remain explosive: If a surprising drug combination continues to destroy a key feature of the disease, then an effective treatment for Alzheimer’s may have been hiding for decades in plain sight.

A promising series of early studies is highlighting two well known medicine cabinet standbys—gemfibrosil, an old-school cholesterol-lowering drug, and retinoic acid, a vitamin A derivative. Gemfibrosil, is sold as Lopid and while it’s still used, it is not widely prescribed. Doctors now prefer to prescribe statins to lower cholesterol. Retinoic acid has been used in various formulations to treat everything from acne to psoriasis to cancer.

A newly discovered papyrus contains an eye-witness account of the gathering of materials for the Great Pyramid.

A new AI architecture that will handle many tasks at once.

On a chilly evening last fall, I stared into nothingness out of the floor-to-ceiling windows in my office on the outskirts of Harvard’s campus. As a purplish-red sun set, I sat brooding over my dataset on rat brains. I thought of the cold windowless rooms in downtown Boston, home to Harvard’s high-performance computing center, where computer servers were holding on to a precious 48 terabytes of my data. I have recorded the 13 trillion numbers in this dataset as part of my Ph.D. experiments, asking how the visual parts of the rat brain respond to movement.

Printed on paper, the dataset would fill 116 billion pages, double-spaced. When I recently finished writing the story of my data, the magnum opus fit on fewer than two dozen printed pages. Performing the experiments turned out to be the easy part. I had spent the last year agonizing over the data, observing and asking questions. The answers left out large chunks that did not pertain to the questions, like a map leaves out irrelevant details of a territory.

But, as massive as my dataset sounds, it represents just a tiny chunk of a dataset taken from the whole brain. And the questions it asks—Do neurons in the visual cortex do anything when an animal can’t see? What happens when inputs to the visual cortex from other brain regions are shut off?—are small compared to the ultimate question in neuroscience: How does the brain work?

None.

Scientists from Heidelberg and Bern have succeeded in training spiking neural networks to solve complex tasks with extreme energy efficiency. The advance was enabled by the BrainScaleS-2 neuromorphic platform, which can be accessed online as part of the EBRAINS research infrastructure.

Developing a machine that processes information as efficiently as the human brain has been a long-standing research goal towards true artificial intelligence. An interdisciplinary research team at Heidelberg University and the University of Bern led by Dr Mihai Petrovici is tackling this problem with the help of biologically-inspired artificial neural networks.

Continue reading “Human Brain Project researchers demonstrate highly efficient deep learning on a spiking neuromorphic chip” »

Researchers from the Technion and the Houston Methodist Research Institute have developed microscopic machines that can deliver drugs to parts of the brain in order to treat injuries and diseases.

Researchers have identified a potential new treatment that suppresses the replication of SARS-CoV-2, the coronavirus that causes Covid-19.

In order to multiply, all viruses, including coronaviruses, infect cells and reprogramme them to produce novel viruses.

The research revealed that cells infected with SARS-CoV-2 can only produce novel coronaviruses when their metabolic pentose phosphate pathway is activated.

The magnetic and particle environment around Mercury was sampled by BepiColombo for the first time during the mission’s close flyby of the planet at 199 km on 1–2 October 2,021 while the huge gravitational pull of the planet was felt by its accelerometers.

The magnetic and accelerometer data have been converted into sound files and presented here for the first time. They capture the ‘sound’ of the solar wind as it bombards a planet close to the Sun, the flexing of the spacecraft as it responded to the change in temperature as it flew from the night to dayside of the planet, and even the sound of a science instrument rotating to its ‘park’ position.

Researchers are growing embryos outside the womb for longer than has ever been possible.