Researchers have created their own temporary tattoo sticker that has a hidden purpose: detecting the presence of one drug used to “spike” alcoholic beverages.
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Stopping DNA damage in T cells during PARP inhibitor cancer treatment enhances antitumor effectiveness
The cancer drugs called PARP inhibitors have a puzzling reputation: even though they are treatment mainstays for multiple forms of cancer, they can damage cancer-killing T cells and disrupt the potential for meaningful therapy. New research from medical scientists in China is revealing ways to sidestep this obstacle by preventing PARP-induced collateral damage to T cells.
A multi-disciplinary team of researchers in Wuhan, working at several collaborating institutions, developed methods to prevent damage and showed that doing so increases the drugs’ efficacy against ovarian tumors and may help expand PARP inhibitors’ overall use. The PARP inhibitor drug family consists of slightly more than half a dozen medications, and the same problems appear consistent in all of them, say investigators participating in the study at Tongji Hospital, Tongji Medical College and Huazhong University of Science and Technology.
Writing in the journal Science Translational Medicine, the Wuhan-based researchers explain that PARP inhibitors have become standard treatments for epithelial ovarian cancer, the most lethal gynecologic cancer. However, PARP inhibitors often can’t eliminate tumors on their own. Doctors have attempted to combine PARP medication with immunotherapies, such as immune checkpoint inhibitors, but results have been mixed, creating yet another obstacle in the PARP treatment saga.
AI agent autonomously solves complex cybersecurity challenges using text-based tools
Artificial intelligence agents—AI systems that can work independently toward specific goals without constant human guidance—have demonstrated strong capabilities in software development and web navigation. Their effectiveness in cybersecurity has remained limited, however.
That may soon change, thanks to a research team from NYU Tandon School of Engineering, NYU Abu Dhabi and other universities that developed an AI agent capable of autonomously solving complex cybersecurity challenges.
The system, called EnIGMA, was presented this month at the International Conference on Machine Learning (ICML) 2025 in Vancouver, Canada.
ASML Reportedly Faces No Tariffs on Equipment Shipments to the U.S., Allowing TSMC, Samsung & Others Ease in Establishing American Facilities
The Dutch chip equipment manufacturer will be exempted from the new US tariffs, allowing chipmakers like TSMC and Samsung easy access to lithography machines in America.
Well, the US and EU recently concluded on a trade deal, setting the tariff rates to the “baseline” 15% figure, along with potential ‘hundreds of billions’ in investments by the EU into America’s energy sector. However, there are tariff exemptions with specific categories, and one of them includes semiconductors, according to a statement released by the European Commission. This means that US companies could import chip equipment and essentials into the nation without paying the extra costs to the government in form of tariffs, and this means great news for the likes of Samsung and TSMC.
Preclinical pitfalls: How to avoid costly formulation failures
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Childhood strokes are rare, so treating them takes an exceptional set of skills
“It’s not a true aspiration catheter, but it can work,” says Sillero. “We have to be careful because the groin is very small at this age — you have to really think outside the box.”
Neurosurgical procedures are especially challenging when operating on kids under two, he explains, partly because medical supply companies don’t make miniature versions of devices such as catheters, since paediatric stroke and aneurysm (a bulge in a blood vessel) are so rare.
Sillero has overcome such challenges not only through improvisation, but thanks to Children’s Health’s innovative model for diagnosis and treatment, which encourages close collaboration between different specialists.