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These insights could drive the development of new drugs to treat transthyretin amyloidosis, a progressive and fatal disease.

Transthyretin, a small but crucial protein, plays a vital role in transporting hormones through the blood and spinal fluid. However, when it misfolds after secretion, it can lead to serious health problems. Misfolded transthyretin forms toxic clumps in the heart and along nerves, causing transthyretin amyloidosis (ATTR)—a progressive and often fatal disease. ATTR affects up to 25% of men over 80, leading to symptoms such as shortness of breath, dizziness, and numbness or tingling in the extremities.

In a breakthrough study, researchers at Scripps Research have revealed new structural insights into transthyretin. Their findings, published in Nature Structural & Molecular Biology.

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What exists at the core of a black hole? A research team led by Enrico Rinaldi, a physicist at the University of Michigan, has leveraged quantum computing and machine learning to analyze the quantum state of a matrix model, providing new insights into the nature of black holes.

The study builds on the holographic principle, which suggests that the fundamental theories of particle physics and gravity are mathematically equivalent, despite being formulated in different dimensions.

Two prevailing theories describe black holes from different dimensional perspectives. In one framework, gravity operates within the three-dimensional geometry of the black hole. In contrast, particle physics is confined to the two-dimensional surface, resembling a flat disk. This duality highlights a key distinction between the two models while reinforcing their interconnected nature.

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To travel between the stars requires vast amounts of fuel and energy, but as it turns out, the ocean of night in deep space is full of fuel, if you can collect it along the way.

The Fishback ramjet revisited: https://www.sciencedirect.com/science…
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Credits: Bussard Ramjet Starship Drive.
Episode 411b, September 10, 2023
Written, Produced & Narrated by: Isaac Arthur.

Graphics:

Continue reading “Bussard Ramjet Starship Drive” | >

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Hello and welcome! My name is Anton and in this video, we will talk about a new study that determines the Bussard Ramjet may not be possible after all.
Links:
https://www.tuwien.at/en/tu-wien/news/news-articles/news/sci…et-antrieb.
https://www.sciencedirect.com/science/article/pii/S0094576521005804
https://en.wikipedia.org/wiki/Bussard_ramjet.
https://en.wikipedia.org/wiki/Project_Orion_(nuclear_propulsion)
https://en.wikipedia.org/wiki/Project_Daedalus.

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Continue reading “Interstellar Engine Bussard Ramjet Is Possible But May Require Insane Magnetic Fields” | >

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Two new recently published, peer-reviewed scientific papers show that real warp drive designs based on real physics may be possible. They are realistic and physical, which had not been the case in the past. In a paper published in 1994, Mexican physicist Miguel Alcubierre showed theoretically that an FTL warp drive could work within the laws of physics. But it would require huge amounts of negative mass or energy. Such a thing is not known to exist.
0:00 Problem with C
2:21 General Relativity.
3:15 Alcubierre warp.
4:40 Bobrick & Martire solution.
7:15 Types of warp drives.
8:42 Spherical Warp drive.
11:32 FTL using Positive Energy.
13:14 Next steps.
14:08 Further education Brilliant.

In a recent paper published by Applied Physics, authors Alexey Bobrick and Gianni Martire, outline how a physically feasible warp drive could in principle, work, without the need for negative energy. I spoke to them. They had technical input on this video.

What Alcubierre did in his paper is figure out a shape that he believed spacetime needed to have in order for a ship to travel faster than light. Then he solved Einstein’s equation for general relativity to determine the matter and energy he would need to generate the desired curvature. It could only work with negative energy. This is mathematically consistent, but meaningless because negative mass is not known to exist. Negative mass is not the same as anti-matter. Antimatter has positive energy and mass.

Continue reading “REAL Warp Drives? NEW research proposes a solution!” | >

Theoretical warp technology exists in what we know as the Alcubierre drive. In this video, I will explain how this theoretical warp technology works and the problems that we face in developing it.
You will also get to see some mathematically accurate simulations of a spaceship using an Alcubierre drive, travelling at 1,000 light years per second!

In Star Trek, Star Wars, Dune and many other sci-fi stories where space travel exists, the common question that viewers have is: how do these humans achieve faster than light travel? The term “Warp travel” and “Warp speed” were originally coined by the Star Trek franchise. It is also known by other franchises as “Jump” or “folding of space” and the engines that cause this to happen are the “warp drive” or the “hyper drive”
Ultimately, the idea of bending space is embedded within all of these sci-fi stories, and with good reason.

It is impossible to travel faster than light within space. But space itself can bend, fold, move, expand at any speed or rate.

The alcubierre drive uses the principals in general relativity to bend space around a spaceship in such a way, that the space itself begins to move, carrying along anything within it. So although the spaceship is not technically moving within the space it occupies, the space around the spaceship allows motion to occur.

Continue reading “The Science behind REAL warp drives” | >

Dr. Simon Stringer. Obtained his Ph.D in mathematical state space control theory and has been a Senior Research Fellow at Oxford University for over 27 years. Simon is the director of the Oxford Centre for Theoretical Neuroscience and Artificial Intelligence, which is based within the Oxford University Department of Experimental Psychology. His department covers vision, spatial processing, motor function, language and consciousness — in particular — how the primate visual system learns to make sense of complex natural scenes. Dr. Stringers laboratory houses a team of theoreticians, who are developing computer models of a range of different aspects of brain function. Simon’s lab is investigating the neural and synaptic dynamics that underpin brain function. An important matter here is the The feature-binding problem which concerns how the visual system represents the hierarchical relationships between features. the visual system must represent hierarchical binding relations across the entire visual field at every spatial scale and level in the hierarchy of visual primitives.

We discuss the emergence of self-organised behaviour, complex information processing, invariant sensory representations and hierarchical feature binding which emerges when you build biologically plausible neural networks with temporal spiking dynamics.

00:00:00 Tim Intro.
00:09:31 Show kickoff.
00:14:37 Hierarchical Feature binding and timing of action potentials.
00:30:16 Hebb to Spike-timing-dependent plasticity (STDP)
00:35:27 Encoding of shape primitives.
00:38:50 Is imagination working in the same place in the brain.
00:41:12 Compare to supervised CNNs.
00:45:59 Speech recognition, motor system, learning mazes.
00:49:28 How practical are these spiking NNs.
00:50:19 Why simulate the human brain.
00:52:46 How much computational power do you gain from differential timings.
00:55:08 Adversarial inputs.
00:59:41 Generative / causal component needed?
01:01:46 Modalities of processing i.e. language.
01:03:42 Understanding.
01:04:37 Human hardware.
01:06:19 Roadmap of NNs?
01:10:36 Intepretability methods for these new models.
01:13:03 Won’t GPT just scale and do this anyway?
01:15:51 What about trace learning and transformation learning.
01:18:50 Categories of invariance.
01:19:47 Biological plausibility.

Pod version: https://anchor.fm/machinelearningstre… https://en.wikipedia.org/wiki/Simon_S… / simon-stringer-a3b239b4 “A new approach to solving the feature-binding problem in primate vision” https://royalsocietypublishing.org/do… James B. Isbister, Akihiro Eguchi, Nasir Ahmad, Juan M. Galeazzi, Mark J. Buckley and Simon Stringer Simon’s department is looking for funding, please do get in touch with him if you can facilitate this. #machinelearning #neuroscience.

Continue reading “#041 Dr. SIMON STRINGER — Biologically Plausible Neural Networks” | >

Researchers at Karolinska Institutet, in collaboration with teams from Lund University and the Center for Regenerative Therapies Dresden (CRTD), have mapped the genome of the Iberian ribbed newt and revealed how the composition and organization of the DNA are linked to its ability to regenerate entire body parts.

The paper is published in the journal Cell Genomics.

Salamanders are known for their unique ability to regenerate entire body parts and for their resistance to tumor development. The behind these traits have been difficult to study due to a lack of knowledge about the composition of their genome. Researchers at Karolinska Institutet have now succeeded in mapping the genome of the Iberian ribbed newt, providing new insights into these fascinating processes.

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When astronomers detected the first long-predicted gravitational waves in 2015, it opened a whole new window into the universe. Before that, astronomy depended on observations of light in all its wavelengths.

We also use light to communicate, mostly . Could we use gravitational waves to communicate?

The idea is intriguing, though beyond our capabilities right now. Still, there’s value in exploring the hypothetical, as the future has a way of arriving sooner than we sometimes think.

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