Lifeboat Foundation

Orally administered collagen peptides could contribute to antiaging by replacing the degraded extracellular matrix proteins caused by photoaging. This study aimed to evaluate the efficacy and safety of low-molecular-weight collagen peptides for treating photoaged and dry skin. In this randomized, placebo-controlled, parallel-group, double-blinded trial, we randomly assigned study participants (n = 100) to either the test product group or placebo group at a 1:1 ratio for 12 weeks. The wrinkle scale score, eye wrinkle volume, roughness parameters, such as the average maximum height of the wrinkle (Rz), arithmetic average within the total measuring length of the wrinkle (Ra), maximum profile valley depth of the wrinkle (Rv), and skin hydration, transepidermal water loss (TEWL), overall elasticity (R2), and ratio of elastic recovery to total deformation (R7) were evaluated at baseline, 6 weeks, and 12 weeks. Safety assessments with serial blood tests were also conducted. Efficacy assessments of data from 84 participants were conducted as the per-protocol analysis. After 12 weeks, the 10-grade crow’s feet photo scale score, eye wrinkle volume, skin roughness parameters (Rz, Ra, and Rv), skin elasticity (R2 and R7), skin hydration, and TEWL were significantly improved in the test product group compared to the placebo group. There were no adverse events or abnormalities according to laboratory analysis associated with using the test material during the study period. This study showed that the oral supplementation of low-molecular-weight collagen peptides could improve the wrinkles, elasticity, hydration, and barrier integrity of photoaged facial skin. This clinical study was registered with the Korean Clinical Research Information Service and International Clinical Trials Registry Platform (No: KCT0006500).

Keywords: clinical study; collagen peptide; photoaging; wrinkles.

Medium-range weather forecasts play a crucial role in agriculture, construction, travel and other industries. They also bring practical value to people’s daily lives, enabling us to plan outings and keeping us safe from extreme weather events. Traditional numerical weather prediction (NWP)-based forecasting…

Year 2021 viable fusion reactor in a z pinch device which is compact enough to fit in a van or airplane ✈️ 😀

The fusion Z-pinch experiment (FuZE) is a sheared-flow stabilized Z-pinch designed to study the effects of flow stabilization on deuterium plasmas with densities and temperatures high enough to drive nuclear fusion reactions. Results from FuZE show high pinch currents and neutron emission durations thousands of times longer than instability growth times. While these results are consistent with thermonuclear neutron emission, energetically resolved neutron measurements are a stronger constraint on the origin of the fusion production. This stems from the strong anisotropy in energy created in beam-target fusion, compared to the relatively isotropic emission in thermonuclear fusion. In dense Z-pinch plasmas, a potential and undesirable cause of beam-target fusion reactions is the presence of fast-growing, “sausage” instabilities. This work introduces a new method for characterizing beam instabilities by recording individual neutron interactions in plastic scintillator detectors positioned at two different angles around the device chamber. Histograms of the pulse-integral spectra from the two locations are compared using detailed Monte Carlo simulations. These models infer the deuteron beam energy based on differences in the measured neutron spectra at the two angles, thereby discriminating beam-target from thermonuclear production. An analysis of neutron emission profiles from FuZE precludes the presence of deuteron beams with energies greater than 4.65 keV with a statistical uncertainty of 4.15 keV and a systematic uncertainty of 0.53 keV. This analysis demonstrates that axial, beam-target fusion reactions are not the dominant source of neutron emission from FuZE. These data are promising for scaling FuZE up to fusion reactor conditions.

The authors would like to thank Bob Geer and Daniel Behne for technical assistance, as well as Amanda Youmans, Christopher Cooper, and Clément Goyon for advice and discussions. The authors would also like to thank Phil Kerr and Vladimir Mozin for the use of their Thermo Fisher P385 neutron generator, which was important in verifying the ability to measure neutron energy shifts via the pulse integral technique. The information, data, or work presented herein was funded in part by the Advanced Research Projects Agency—Energy (ARPA-E), U.S. Department of Energy, under Award Nos. DE-AR-0000571, 18/CJ000/05/05, and DE-AR-0001160. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract No. DE-AC52-07NA27344 and Lawrence Berkeley National Laboratory under Contract No. DE-AC02-05CH11231. U.

Who knows what impact the chatbot will ultimately have. But a new report from Burning Glass Institute done in partnership with Business-Higher Education Forum and Wiley shows that artificial intelligence and machine learning skills are not only among the fastest growing and widest spreading skill sets across industries in the job market—but having them can mean workers get paid more, rather than less in their jobs.

“The notion that automation is this lurking menace on the horizon is something we should rethink,” says Matt Sigelman, president of the labor market research nonprofit Burning Glass Institute. “We’re seeing that people whose work involves leveraging automation skills get paid significantly more than those who don’t.”

Rationally designed bioinks enable bioprinting of mechanically and physiologically relevant vascular conduits.

In November 2021, while the municipal utility in Marburg, Germany, was performing scheduled maintenance on a hot water storage facility, engineers glued 18 solar panels to the outside of the main 10-meter-high cylindrical tank. It’s not the typical home for solar panels, most of which are flat, rigid silicon and glass rectangles arrayed on rooftops or in solar parks. The Marburg facility’s panels, by contrast, are ultrathin organic films made by Heliatek, a German solar company. In the past few years, Heliatek has mounted its flexible panels on the sides of office towers, the curved roofs of bus stops, and even the cylindrical shaft of an 80-meter-tall windmill. The goal: expanding solar power’s reach beyond flat land. “There is a huge market where classical photovoltaics do not work,” says Jan Birnstock, Heliatek’s chief technical officer.

Organic photovoltaics (OPVs) such as Heliatek’s are more than 10 times lighter than silicon panels and in some cases cost just half as much to produce. Some are even transparent, which has architects envisioning solar panels not just on rooftops, but incorporated into building facades, windows, and even indoor spaces. “We want to change every building into an electricity-generating building,” Birnstock says.

Heliatek’s panels are among the few OPVs in practical use, and they convert about 9% of the energy in sunlight to electricity. But in recent years, researchers around the globe have come up with new materials and designs that, in small, labmade prototypes, have reached efficiencies of nearly 20%, approaching silicon and alternative inorganic thin-film solar cells, such as those made from a mix of copper, indium, gallium, and selenium (CIGS). Unlike silicon crystals and CIGS, where researchers are mostly limited to the few chemical options nature gives them, OPVs allow them to tweak bonds, rearrange atoms, and mix in elements from across the periodic table. Those changes represent knobs chemists can adjust to improve their materials’ ability to absorb sunlight, conduct charges, and resist degradation. OPVs still fall short on those measures. But, “There is an enormous white space for exploration,” says Stephen Forrest, an OPV chemist at the University of Michigan, Ann Arbor.

More energy out than in. For 7 decades, fusion scientists have chased this elusive goal, known as energy gain. At 1 a.m. on 5 December, researchers at the National Ignition Facility (NIF) in California finally did it, focusing 2.05 megajoules of laser light onto a tiny capsule of fusion fuel and sparking an explosion that produced 3.15 MJ of energy—the equivalent of about three sticks of dynamite.

“This is extremely exciting, it’s a major breakthrough,” says Anne White, a plasma physicist at the Massachusetts Institute of Technology, who was not involved in the work.

Mark Herrmann, who leads NIF as the program director for weapons physics and design at Lawrence Livermore National Laboratory, says it feels “wonderful,” adding: “I’m so proud of the team.”

This microbe has evolved specialized cells that make it unique among multicellular bacteria.

Dec 13, 2022 — There are several different types of stem cells, each with its own unique properties and applications in medical research and practice.