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Recent research from the S: CORT team has identified key biomarkers and treatment strategies that predict and enhance effectiveness of radiotherapy in rectal cancer treatment.

Patients with advanced rectal cancer often receive radiotherapy before surgery. However, despite this being standard practice, this treatment only results in complete disappearance (complete response) prior to surgery in 15% of patients.

Currently, there are no reliable biomarkers (a biological molecule found in blood, other , or tissues that is a sign of a normal or abnormal process, or of a condition or disease) to predict which colorectal patients will benefit from radiotherapy, meaning that many patients are unnecessarily exposed to significant side effects.

Researchers have discovered new connections between the gut and brain that hold promise for more targeted treatments for depression and anxiety, and could help prevent digestive issues in children by limiting the transmission of antidepressants during pregnancy.

The study, published in the journal Gastroenterology, shows that increasing serotonin in the gut epithelium—the thin layer of cells lining the small and large intestines—improves symptoms of anxiety and depression in animal studies. The researchers also found that, in humans, antidepressant use during increases the risk of babies developing constipation in the first year of life.

“Our findings suggest that there may be an advantage to targeting antidepressants selectively to the gut epithelium, as systemic treatment may not be necessary for eliciting the drugs’ benefits but may be contributing to digestive issues in children exposed during pregnancy,” said Kara Margolis, director of the NYU Pain Research Center and associate professor of molecular pathobiology at NYU College of Dentistry, who co-led the study with Mark Ansorge, associate professor of clinical neurobiology at Columbia University.

NASA’s James Webb Space Telescope (JWST) has for the first time captured an image of what our galaxy likely looked like just as it was forming — and it’s got space scientists feeling very Christmassy.

“I just love the sparkle galaxy with its Christmas lights shining as it was when the Universe was just 600 million years old,” Prof Catherine Heymans, Scotland’s Astronomer Royal, told BBC News.

The image shows ten balls of stars of different colours, appearing like Christmas tree baubles hanging in the cosmos.

HighlyCitedPapers.

📝 — Schulze, et al.

The present work reviews the strategies and technical approaches used to overcome the multilayered problems associated with large bone defect healing in long bones, with emphasis on research rooted in scaffold-guided tissue regeneration.

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HighlyCitedPapers.

📝 The Many Faces of Immune Activation in HIV-1 Infection: A Multifactorial Interconnection — Mazzuti, et al.

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Ovarian cancer (OC) is the leading cause of death from gynecological malignancies. Despite great advances in treatment strategies, therapeutic resistance and the gap between preclinical data and actual clinical efficacy justify the necessity of developing novel models for investigating OC. Organoids represent revolutionary three-dimensional cell culture models, deriving from stem cells and reflecting the primary tissue’s biology and pathology. The aim of the current review is to study the current status of mouse-and patient-derived organoids, as well as their potential to model carcinogenesis and perform drug screenings for OC.