Lifeboat Foundation

Many cancer cells never leave their original tumors. Some cancer cells evolve the ability to migrate to other tissues, but once there cannot manage to form new tumors, and so remain dormant. The deadliest cancer cells are those that can not only migrate to, but also thrive and multiply in distant tissues.

These metastatic cancer cells are responsible for most of the deaths associated with cancer. Understanding what enables some cancer cells to metastasize—to spread and form new tumors—is an important goal for researchers, as it will help them develop therapies to prevent or reverse those deadly occurrences.

Past research from Whitehead Institute Member Robert Weinberg and others suggests that cancer cells are best able to form metastatic tumors when the cells are in a particular state called the quasi-mesenchymal (qM) state. New research from Weinberg and Arthur Lambert, once a postdoc in Weinberg’s lab and now an associate director of translational medicine at AstraZeneca, has identified two gene-regulating molecules as important for keeping cancer cells in the qM state.

Immunotherapy, including immune checkpoint inhibitors (ICIs), has changed the landscape of cancer treatment in the last decade. Immunotherapies, treatments targeting a patient’s immune system instead of the cancer itself, work on cancers considered “hot,” indicating that the tumor contains immune cells and factors which favor an anti-tumor immune response. Cancers that respond to immune-based therapies are known as “immunogenic” since the treatment can stimulate the immune response.

On the other hand, “cold” cancers, characterized as “non-immunogenic,” fail to respond to immunotherapies. One cancer understood as refractory to immune-based regimens is pancreatic ductal adenocarcinoma (PDAC), a highly aggressive pancreatic malignancy where less than 10% of patients survive five years past diagnosis. ICIs, including those targeting PD-L1 and CTLA-4 lack the efficacy to impact survival outcomes in PDAC patients significantly. Further, estimates project that by 2030, PDAC will rise to the second-highest cause of cancer-related deaths. Thus, there remains a significant need to develop novel and practical strategies to treat patients with this disease.

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What is the Drake Equation? We are talking about The Odds of ALIEN LIFE.
Is there life out there in the Universe?
How are the chances to find Extraterrestrial life?

Continue reading “What Are The Odds Of Alien Life? The Drake Equation” »

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The rate of ground-breaking scientific discoveries and technological innovation is slowing down despite an ever-growing amount of knowledge, according to an analysis released Wednesday of millions of research papers and patents.

While previous research has shown downturns in individual disciplines, the study is the first that “emphatically, convincingly documents this decline of disruptiveness across all major fields of science and technology,” lead author Michael Park told AFP.

Park, a doctoral student at the University of Minnesota’s Carlson School of Management, called disruptive discoveries those that “break away from existing ideas” and “push the whole scientific field into new territory.”

It’s an early step forward and needs way more testing. But the potential is high. Cancer vaccines aren’t a new idea. They use the same fundamentals that enable vaccines for infectious pathogens like viruses and bacteria: priming our immune system into recognizing and attacking something that’s harmful to our bodies.

Nuclear morphology changes with aging, but the role of these changes and the underlying mechanisms are not fully understood. The authors find that the nuclear envelope anchor protein ANC-1 in worms, and its counterpart nesprin-1 and nesprin-2 in mammals, promotes the degradation of nuclear components to limit nucleolar size and function in a soma longevity and germline immortality mechanism.

Series — Clinical Trials on Alzheimer’s Disease (CTAD) 2022: Part 1 of 14: Dare We Say Consensus Achieved: Lecanemab Slows the Disease Part 2 of 14: Brexpiprazole Eases Agitation in People with AD; So Does Being in a Trial Part 3 of 14: Two New Stabs at Vaccinating People Against Pathologic Tau Part 4 of 14: Cognitive Tests Taken at Home Are on Par with In-Clinic Assessments Part 5 of 14: In Small Trial, Gene Therapy Spurs ApoE2 Production Part 6 of 14: Donanemab Mops Up Plaque Faster Than Aduhelm Part 7 of 14: Gantenerumab Mystery: How Did It Lose Potency in Phase 3? Part 8 of 14: Could Personalizing Multimodal Interventions Give Them Oomph?

If you’ve ever thought your children in elementary school were “smarter” than you, or at least quicker at taking up new skills and knowledge, new research published in the journal Current Biology confirms that you were correct. According to the new study, there are differences in the brain messenger GABA between kids and adults, which may explain why kids often seem to be more capable of learning and retaining new information.

“Our results show that children of elementary school age can learn more items within a given period of time than adults, making learning more efficient in children,” said Takeo Watanabe of Brown University.

According to the study, children experienced a rapid increase in GABA during visual training, which lasted even after the training ended. In contrast, GABA concentrations in adults remained constant during training. These findings suggest that children’s brains are more responsive to training, allowing them to quickly and efficiently consolidate new learning.