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Continue reading “Battlefleets: In the future, fleets of unimaginable scope may battle over light years, in conflicts that might last milliseconds or entire centuries” »

Isaac arthur rokos basilisk.

The dangers of artificial intelligence have long loomed in our future, and seem ever closer. But it may be that the dangers of the future can reach back into the past itself, and even without a time machine.

Continue reading “Roko’s Basilisk: Dangerous Knowledge & All-Powerful AI” »

To be able to make full use of these modeling systems, researchers have developed a growing toolkit of genetic modification techniques. These techniques can be applied to mature brain organoids or to the preceding embryoid bodies (EBs) and founding cells. This review will describe techniques used for transient and stable genetic modification of brain organoids and discuss their current use and respective advantages and disadvantages. Transient approaches include adeno-associated virus (AAV) and electroporation-based techniques, whereas stable genetic modification approaches make use of lentivirus (including viral stamping), transposon and CRISPR/Cas9 systems. Finally, an outlook as to likely future developments and applications regarding genetic modifications of brain organoids will be presented.

The development of brain organoids (Kadoshima et al., 2013; Lancaster et al., 2013) has opened up new ways to study brain development and evolution as well as neurodevelopmental disorders. Brain organoids are multicellular 3D structures that mimic certain aspects of the cytoarchitecture and cell-type composition of certain brain regions over a particular developmental time window (Heide et al., 2018). These structures are generated by differentiation of induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs) into embryoid bodies followed by, or combined, with neural induction (Kadoshima et al., 2013; Lancaster et al., 2013). In principle, two different classes of brain organoid protocols can be distinguished, namely: (i) the self-patterning protocols which produce whole-brain organoids; and (ii) the pre-patterning protocols which produce brain region-specific organoids (Heide et al., 2018).

Everybody is talking about Artificial Intelligence (AI). It is in our computers, services and even our mobile phones. The AI composes our messages, predicts our moves and even takes photos for us. Are we – humans – going to become “obsolete” in a matter of years?! Maybe there is a last chance – Intelligence Amplification (IA).

While an AI needs to be developed from scratch, we humans, already have great intelligence thanks to countless years of evolution. A modern human’s brain is an awesome tool!

Among us, there are some geniuses, but imagine if everybody can become one. And not just a genius, but a super-genius. Smarter than every person who has ever lived before! This is the idea behind Intelligence Amplification. To use our intelligence as a base and to add computers to make us smarter beyond our imagination. A hybrid, a work of art!

This is de Garis ESSAYS, i.e. 2–3 page opinion pieces on such themes as Species Dominance, Global State, Politics, Femtotech, Religion, Society, Education. Written, Read Aloud and Videoed by Prof. Dr. Hugo de Garis [email protected] https://profhugodegaris.wordpress.com

The world’s first brain prosthesis has passed the first stages of live testing.

The microchip, designed to model a part of the brain called the hippocampus, has been used successfully to replace a neural circuit in slices of rat brain tissue kept alive in a dish. The prosthesis will soon be ready for testing in animals.

The device could ultimately be used to replace damaged brain tissue which may have been destroyed in an accident, during a stroke, or by neurodegenerative conditions such as Alzheimer’s disease. It is the first attempt to replace central brain regions dealing with cognitive functions such as learning or speech.

When stressed, this comb jelly reverts to a larval form, then matures again when favorable conditions return.

While silicon-based computing is cutting-edge today, human brain-based tech could be on track to dominate the future.

Texas is known as the dominant oil state in the US, and its grid is not the most renewable in the world. But because of its size, its traditional reliance on fossil fuels, and its rapid recent uptake of solar and batteries in the face of fierce winter storms and searing summer heat, it has been centre stage for those watching the energy transition.

It’s also interesting for Australia, because although it has about the same population, its grid demand is almost twice as great as Australia’s main grid, yet its average wind and solar penetration (31 per cent) and its peak instantaneous wind and solar penetration (71 per cent) are about the same.

While Australia is dependent still on coal, the main fossil on the Texas grid is gas, with supporting roles for nuclear and an ever decreasing amount of coal. Texas made its initial move into renewables with big wind, but is now more focused on large scale solar and battery storage.